scholarly journals Letter to the Editor: “Association of Vitamin D Deficiency With Peripheral Arterial Disease: A Meta-Analysis of Literature Studies”

2018 ◽  
Vol 103 (12) ◽  
pp. 4447-4447
Author(s):  
Anawin Sanguankeo ◽  
Sikarin Upala
Keyword(s):  
Vitamin D ◽  
Peripheral Arterial Disease ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Arterial Disease ◽  
Letter To The Editor ◽  
Peripheral Arterial

scholarly journals Association of Vitamin D Deficiency With Peripheral Arterial Disease: A Meta-Analysis of Literature Studies

2018 ◽  
Vol 103 (6) ◽  
pp. 2107-2115 ◽  
Author(s):  
Gabriella Iannuzzo ◽  
Francesco Forte ◽  
Roberta Lupoli ◽  
Matteo Nicola Dario Di Minno
Keyword(s):  
Vitamin D ◽  
Peripheral Arterial Disease ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation

2019 ◽  
Vol 20 (19) ◽  
pp. 4907 ◽  
Author(s):  
Smriti Murali Krishna
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Peripheral Arterial Disease ◽  
Vitamin D Deficiency ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Experimental Studies ◽  
Arterial Disease ◽  
Current Evidence ◽  
Peripheral Arterial

Atherosclerotic occlusive diseases and aneurysms that affect large and medium-sized arteries outside the cardiac and cerebral circulation are collectively known as peripheral arterial disease (PAD). With a rise in the rate of aging population worldwide, the number of people diagnosed with PAD is rapidly increasing. The micronutrient vitamin D is an important steroid hormone that acts on many crucial cellular mechanisms. Experimental studies suggest that optimal levels of vitamin D have beneficial effects on the heart and blood vessels; however, high vitamin D concentrations have been implicated in promoting vascular calcification and arterial stiffness. Observations from various clinical studies shows that deficiency of vitamin D has been associated with a greater risk of PAD. Epidemiological studies have often reported an inverse relation between circulating vitamin D status measured in terms of 25-hydroxivitamin D [25(OH)D] levels and increased cardiovascular disease risk; however, randomized controlled trials did not show a consistent positive effect of vitamin D supplementation on cardiovascular disease risk or events. Even though PAD shares all the major risk factors with cardiovascular diseases, the effect of vitamin D deficiency in PAD is not clear. Current evidence suggests a strong role of vitamin D in promoting genomic and epigenomic changes. This review summarises the current literature that supports the notion that vitamin D deficiency may promote PAD formation. A better understanding of underlying pathological mechanisms will open up new therapeutic possibilities which is the main unmet need in PAD management. Furthermore, epigenetic evidence shows that a more holistic approach towards PAD prevention that incorporates a healthy lifestyle, adequate exercise and optimal nutrition may be more effective in protecting the genome and maintaining a healthy vasculature.

Vitamin D Deficiency: An Increasing Concern in Peripheral Arterial Disease

2010 ◽  
Vol 11 (5) ◽  
pp. 308-311 ◽  
Author(s):  
Vamsi C. Gaddipati ◽  
Reena Kuriacose ◽  
Rebecca Copeland ◽  
Beth A. Bailey ◽  
Alan N. Peiris
Keyword(s):  
Vitamin D ◽  
Peripheral Arterial Disease ◽  
Vitamin D Deficiency ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease

2002 ◽  
Vol 17 (9) ◽  
pp. 663-669 ◽  
Author(s):  
Astrid Fahrleitner ◽  
Harald Dobnig ◽  
Andrea Obernosterer ◽  
Ernst Pilger ◽  
Georg Leb ◽  
...  
Keyword(s):  
Vitamin D ◽  
Peripheral Arterial Disease ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Arterial Disease ◽  
Peripheral Arterial
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