scholarly journals Timing of antiretroviral therapy initiation after diagnosis of recent human immunodeficiency virus infection and CD4+ T-cell recovery

2016 ◽  
Vol 22 (3) ◽  
pp. 290.e5-290.e8 ◽  
Author(s):  
Y. Ding ◽  
S. Duan ◽  
Z. Wu ◽  
R. Ye ◽  
Y. Yang ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Cd4 T Cell ◽  
Cell Recovery ◽  
Therapy Initiation ◽  
Immunodeficiency Virus

Longitudinal analysis of T-cell receptor gene use by CD8+ T cells in early human immunodeficiency virus infection in patients receiving highly active antiretroviral therapy

Blood ◽  
2001 ◽  
Vol 97 (1) ◽  
pp. 214-220 ◽  
Author(s):  
Anna M. Schito ◽  
Eric Vittinghoff ◽  
Frederick M. Hecht ◽  
Mary K. Elkins ◽  
James O. Kahn ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
T Cell Receptor ◽  
Highly Active Antiretroviral Therapy ◽  
Cell Receptor ◽  
Highly Active ◽  
Immunodeficiency Virus

Abstract The effects of early antiretroviral therapy on the peripheral CD8+ T-cell population were assessed by sequentially determining the T-cell receptor (TCR) repertoire complexity in a cohort of 15 individuals recently diagnosed with human immunodeficiency virus infection. Analysis was based on quantitative TCR variable B gene (TCRBV) usage and complementary-determining region 3 length assessment. Repertories were assessed at baseline and at weeks 2, 4, 12, 24, and 72 after initiation of therapy. Early administration of highly active antiretroviral therapy has a positive effect on the preservation and homeostasis of the CD8+ cell repertoire. Nevertheless, differences from average baseline and control TCR profiles and initial development of repertoire perturbations were observed. The findings suggest that additional therapeutic protocols will be required during primary infection to significantly prevent long-term erosion of the T-cell–mediated immune response.

Psychosis Induced by Decreased CD4+ T Cell and High Viral Load in Human Immunodeficiency Virus Infection: A Case Report

2008 ◽  
Vol 64 (9) ◽  
pp. e3-e4 ◽  
Author(s):  
Mar Álvarez-Segura ◽  
Sonia Villero ◽  
Enrique Portugal ◽  
Maria Mayoral ◽  
Pedro Montilla ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Viral Load ◽  
T Cell ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
High Viral Load ◽  
Cd4 T Cell ◽  
Immunodeficiency Virus

scholarly journals Human immunodeficiency virus infection with multiple opportunistic infections: lessons learnt from a non-adherent patient

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Manish Soneja ◽  
Anivita Aggarwal ◽  
Parul Kodan ◽  
Nitin Gupta
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Cytomegalovirus Infection ◽  
Opportunistic Infections ◽  
Pneumocystis Carinii ◽  
Adherent Patient ◽  
Immunodeficiency Virus ◽  
Adherence Counselling

Abstract We report a case of advanced human immunodeficiency virus (HIV) infection with multiple opportunistic infections (Pneumocystis carinii pneumonia, cryptosporidiosis, oesophagal candidiasis and cytomegalovirus infection). The patient was presumed to be adherent on antiretroviral therapy (ART) and was initiated on respective treatments for the opportunistic infections but continued to deteriorate. On further reviewing, he was found to be poorly adherent to ART and was advised enhanced adherence counselling after which his condition improved. We report this case to emphasize the importance of adherence to ART medications in the management of patients with HIV.

scholarly journals Antiretroviral Therapy Effects on Genetic and Morphologic End Points in Lymphocytes and Sperm of Men with Human Immunodeficiency Virus Infection

2001 ◽  
Vol 184 (2) ◽  
pp. 127-135 ◽  
Author(s):  
Wendie A. Robbins ◽  
Kristine L. Witt ◽  
Joseph K. Haseman ◽  
David B. Dunson ◽  
Luigi Troiani ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
End Points ◽  
Immunodeficiency Virus
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