A Progressive Somatic Cell Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary

2020 ◽  
Author(s):  
Jingyuan Shi ◽  
Zhen Jin ◽  
Yaxin Yu ◽  
Yongchao Zhang ◽  
Fu Yang ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Germline Cyst ◽  
Cell Niche ◽  
Drosophila Ovary

scholarly journals A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis

PLoS Biology ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. e3000538 ◽  
Author(s):  
Allison Jevitt ◽  
Deeptiman Chatterjee ◽  
Gengqiang Xie ◽  
Xian-Feng Wang ◽  
Taylor Otwell ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Single Cell ◽  
Cell Lineage ◽  
Drosophila Ovary ◽  
Adult Drosophila ◽  
Somatic Cell Lineage

scholarly journals Cyclin A Associates with the Fusome during Germline Cyst Formation in the Drosophila Ovary

2000 ◽  
Vol 218 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Mary A. Lilly ◽  
Margaret de Cuevas ◽  
Allan C. Spradling
Keyword(s):  
Cyclin A ◽  
Cyst Formation ◽  
Germline Cyst ◽  
Drosophila Ovary

scholarly journals Cancer treatment in childhood and testicular function: the importance of the somatic environment

2018 ◽  
Vol 7 (2) ◽  
pp. R69-R87 ◽  
Author(s):  
Jan-Bernd Stukenborg ◽  
Kirsi Jahnukainen ◽  
Marsida Hutka ◽  
Rod T Mitchell
Keyword(s):  
Stem Cell ◽  
Cancer Treatment ◽  
Somatic Cell ◽  
Stem Cell Niche ◽  
Subsequent Development ◽  
Experimental Models ◽  
Cell Populations ◽  
Testicular Function ◽  
Future Fertility ◽  
Cell Niche

Testicular function and future fertility may be affected by cancer treatment during childhood. Whilst survival of the germ (stem) cells is critical for ensuring the potential for fertility in these patients, the somatic cell populations also play a crucial role in providing a suitable environment to support germ cell maintenance and subsequent development. Regulation of the spermatogonial germ-stem cell niche involves many signalling pathways with hormonal influence from the hypothalamo-pituitary-gonadal axis. In this review, we describe the somatic cell populations that comprise the testicular germ-stem cell niche in humans and how they may be affected by cancer treatment during childhood. We also discuss the experimental models that may be utilized to manipulate the somatic environment and report the results of studies that investigate the potential role of somatic cells in the protection of the germ cells in the testis from cancer treatment.

scholarly journals ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary

PLoS Genetics ◽  
2016 ◽  
Vol 12 (1) ◽  
pp. e1005763 ◽  
Author(s):  
John R. Pearson ◽  
Federico Zurita ◽  
Laura Tomás-Gallardo ◽  
Alfonsa Díaz-Torres ◽  
María del Carmen Díaz de la Loza ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Cyst Production ◽  
Cell Niche ◽  
Drosophila Ovary

scholarly journals Musashi regulates follicle stem cell maintenance and epithelial niche homeostasis in the Drosophila ovary

2020 ◽  
Author(s):  
Nicole A. Siddall ◽  
Franca Casagranda ◽  
Nicole Dominado ◽  
James Heaney ◽  
Jessie M. Sutherland ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Wnt Pathway ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Stem Cell Population ◽  
Stem Cell Maintenance ◽  
Lineage Differentiation ◽  
Cell Niche ◽  
Drosophila Ovary

AbstractThe Musashi (Msi) family of RNA-binding proteins regulate maintenance and differentiation of stem cells in multiple tissues of different species. Here, we use the powerful system of the Drosophila ovary to uncover an intrinsic requirement for Msi in both the maintenance of the follicle stem cell population and regulation of the architecture of the follicle stem cell niche. Further, we demonstrate an associated G2 lag of cycling somatic cells within the niche when Msi function is abrogated. Additionally, we show that Msi interaction with the Wnt pathway influences differentiation of anterior germarial escort cells from cells within the follicle stem cell niche region. This provides further evidence that escort cells can be derived from follicle stem/precursor cells and that Msi regulates lineage differentiation of follicle stem cell daughters.

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