Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-α-activated retinal pigment epithelial cells

Cytokine ◽  
2019 ◽  
Vol 116 ◽  
pp. 48-60 ◽  
Author(s):  
Shu-Chen Cheng ◽  
Yi-Hong Wu ◽  
Wen-Chung Huang ◽  
Jong-Hwei S. Pang ◽  
Tse-Hung Huang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Pigment Epithelial ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Pigment Epithelial Cells

Exenatide modulates expression of metalloproteinases and their tissue inhibitors in TNF-α stimulated human retinal pigment epithelial cells

2019 ◽  
Vol 71 (1) ◽  
pp. 175-182 ◽  
Author(s):  
Wojciech Garczorz ◽  
Enrique Gallego-Colon ◽  
Agnieszka Kosowska ◽  
Krzysztof Siemianowicz ◽  
Agnieszka Kłych-Ratuszny ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Tissue Inhibitors ◽  
Pigment Epithelial ◽  
Tnf Α ◽  
Pigment Epithelial Cells

scholarly journals Retinal pigment epithelial cells display specific transcriptional responses upon TNF-α stimulation

2015 ◽  
Vol 99 (5) ◽  
pp. 700-704 ◽  
Author(s):  
Nicoline M Korthagen ◽  
Kiki van Bilsen ◽  
Sigrid M A Swagemakers ◽  
Jeroen van de Peppel ◽  
Jeroen Bastiaans ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Transcriptional Responses ◽  
Pigment Epithelial ◽  
Tnf Α ◽  
Pigment Epithelial Cells

scholarly journals GPR109A as an Anti-Inflammatory Receptor in Retinal Pigment Epithelial Cells and Its Relevance to Diabetic Retinopathy

2012 ◽  
Vol 53 (4) ◽  
pp. 2208 ◽  
Author(s):  
Deeksha Gambhir ◽  
Sudha Ananth ◽  
Rajalakshmi Veeranan-Karmegam ◽  
Selvakumar Elangovan ◽  
Shanterian Hester ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Pigment Epithelial ◽  
Anti Inflammatory ◽  
Pigment Epithelial Cells

scholarly journals Extracellular Soluble Membranes from Retinal Pigment Epithelial Cells Mediate Apoptosis in Macrophages

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1193
Author(s):  
Nayan Sanjiv ◽  
Pawarissara Osathanugrah ◽  
Emma Fraser ◽  
Tat Fong Ng ◽  
Andrew W. Taylor
Keyword(s):  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Inflammatory Factors ◽  
Pigment Epithelial ◽  
Soluble Mediator ◽  
Macrophage Apoptosis ◽  
Anti Inflammatory ◽  
Pigment Epithelial Cells

A central characterization of retinal immunobiology is the prevention of proinflammatory activity by macrophages. The retinal pigment epithelial cells (RPEs) are a major source of soluble anti-inflammatory factors. This includes a soluble factor that induces macrophage apoptosis when the activity of the immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (α-MSH) is neutralized. In this manuscript, isolated extracellular soluble membranes (ESMs) from primary RPE were assayed to see if they could be the soluble mediator of apoptosis. Our results demonstrated that RPE ESMs mediated the induction of macrophage apoptosis that was suppressed by α-MSH. In contrast, the RPE line ARPE-19, cultured under conditions that induce similar anti-inflammatory activity to primary RPEs, did not activate apoptosis in the macrophages. Moreover, only the ESMs from primary RPE cultures, and not those from the ARPE-19 cell cultures, expressed mFasL. The results demonstrate that RPE ESMs are a soluble mediator of apoptosis and that this may be a mechanism by which the RPEs select for the survival of α-MSH-induced suppressor cells.

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