Tumor necrosis factor-α (TNF-α) −863C/A promoter polymorphism is associated with type 2 diabetes in Tunisian population

2013 ◽  
Vol 102 (2) ◽  
pp. e24-e28 ◽  
Author(s):  
Amani Kallel ◽  
Bochra Ftouhi ◽  
Zeineb Jemaa ◽  
Imen Mahjoubi ◽  
Moncef Feki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Promoter Polymorphism ◽  
Tunisian Population ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Interaction of the −308G/A Promoter Polymorphism of the Tumor Necrosis Factor-α Gene with Single-Nucleotide Polymorphism 45 of the Adiponectin Gene: Effect on Serum Adiponectin Concentrations in a Spanish Population

2006 ◽  
Vol 52 (1) ◽  
pp. 97-103 ◽  
Author(s):  
José L González-Sánchez ◽  
María J Martínez-Calatrava ◽  
María T Martínez-Larrad ◽  
Carina Zabena ◽  
Cristina Fernández-Pérez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Promoter Polymorphism ◽  
Adiponectin Gene ◽  
Single Nucleotide ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Abstract Background: We investigated whether interactions of the −308G/A polymorphism in the promoter region of the tumor necrosis factor-α (TNF-α) gene with single-nucleotide polymorphisms (SNPs) 45 and 276 of the adiponectin gene are associated with circulating adiponectin and soluble TNF-α receptor 2 (sTNFR2) concentrations in a Spanish population. Methods: We performed anthropometric and physiologic measurements in 809 unrelated participants recruited with a simple random sampling approach from respondents to a cross-sectional population-based epidemiologic survey in the province of Segovia in central Spain (Castille). Results: The 2-h postload glucose and serum insulin concentrations were higher in −308A allele carriers than in −308G/G individuals homozygous for the TNF-α gene. Plasma concentrations of sTNFR2 were positively correlated with body mass index, waist-to-hip ratio, and sagittal abdominal diameter among individuals with type 2 diabetes. Individuals with type 2 diabetes and the −308A allele had higher sTNFR2 and lower adiponectin concentrations than −308G homozygotes. Moreover, individuals carrying both the TNF-α −308A allele and the G allele of SNP 45 in the adiponectin gene had the highest prevalence of impaired glucose tolerance (adjusted odds ratio, 1.26; 95% confidence interval, 1.01–1.56; P = 0.038) and had lower adiponectin concentrations (β = −0.090; P = 0.005) than individuals without these genotypes. Conclusions: Our findings are the first to indicate that a higher incidence of impaired glucose tolerance and low circulating adiponectin concentration may be associated with interaction between the −308G/A promoter polymorphism of the TNF-α gene and SNP 45 in the adiponectin gene.

scholarly journals Low Levels of Tumor Necrosis Factor-α will Prevent Periodontitis Exacerbation in Type 2 Diabetes Mellitus

2022 ◽  
Author(s):  
Titiek Berniyanti ◽  
Gilang Rasuna Sabdho Wening ◽  
Retno Palupi ◽  
Dini Setyowati ◽  
Cindy Ramadhan Putri
Keyword(s):  
Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Treatment Needs ◽  
Type 2 Dm ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Abstract Objectives Diabetes mellitus (DM) is a major risk factor for periodontitis. Susceptibility to periodontitis increases approximately three times in people with DM. There is a clear relationship between the degree of hyperglycemia and the severity of periodontitis. This study aimed to analyze the reduction of tumor necrosis factor-α (TNF-α) in diabetics who came for periodontitis examination to prevent exacerbations. Materials and Methods This was an analytic observational study using a cross-sectional approach at health centers in Surabaya, Indonesia. Measurement of periodontal status used the community periodontal index of treatment needs by measuring bleeding at probing and pocket depth. TNF-α was measured using enzyme-linked immunosorbent assay, and behavior and lifestyle using a questionnaire. Statistical Analysis The Kolmogorov–Smirnov test was performed to identify data normality (p < 0.05). A nonparametric test was used to measure the degree of association between different characteristics and the incidence of periodontitis in type 2 DM patients with and without periodontitis. Spearman's test was done to examine the correlation between TNF-α level and severity of periodontitis in diabetics. The significant level was at p <0.05. Results There was a correlation between age, predisposing factors, reinforcing factors, drug consumption, and TNF-α levels in patients with type 2 DM and the incidence of periodontitis. Conclusions Poor glycemic control can induce oxidative stress on the gingiva, thereby aggravating damage to periodontal tissue. An important factor in preventing periodontitis for type 2 DM patients is controlling blood sugar levels through regular consumption of drugs and regular maintenance of oral cavity health. Knowledge is a predisposing factor that affects adherence of people with type 2 DM to consuming drugs regularly, which can be strengthened by family support. These will ultimately play a role in reducing TNF-α levels.

Evaluation of Endocan and Tumor Necrosis Factor-α as Inflammatory Biomarkers in Type 2 Diabetes and Periodontal Disease

2020 ◽  
Vol 24 (7) ◽  
pp. 431-435 ◽  
Author(s):  
Gayathri Kumar ◽  
Deepa Ponnaiyan ◽  
Harinath Parthasarathy ◽  
Anupama Tadepalli ◽  
Suresh Veeramani
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Necrosis Factor ◽  
Periodontal Disease ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Inflammatory Biomarkers ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor α −238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitus

Metabolism ◽  
2007 ◽  
Vol 56 (5) ◽  
pp. 649-655 ◽  
Author(s):  
Bénédicte Fontaine-Bisson ◽  
Thomas M.S. Wolever ◽  
Jean-Louis Chiasson ◽  
Rémi Rabasa-Lhoret ◽  
Pierre Maheux ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Upregulation of Tumor Necrosis Factor-α-Induced Protein 8-Like 2 mRNA Is Negatively Correlated with Serum Concentrations of Tumor Necrosis Factor-α and Interleukin 6 in Type 2 Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Yongliang Liu ◽  
Xinmei Wang ◽  
Yan Zhao ◽  
Peiqing Zhao ◽  
Lianqing Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Healthy Controls ◽  
Factor Α ◽  
Necrosis Factor

Background. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a negative regulator of natural and adaptive immunity. The role of TIPE2 in type 2 diabetes mellitus (T2DM) remains unknown, although TIPE2 plays key roles in preserving inflammatory homeostasis. Methods. TIPE2 expression was measured by Western blotting and real-time polymerase chain reaction (RT-PCR) in peripheral blood mononuclear cells (PBMCs) isolated from T2DM patients and healthy controls, and tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and other related biometabolic parameters were detected using a nephelometer or by ELISA. Differentiated THP-1 cells were exposed to siTIPE2 and TIPE2 adenovirus. Results. TIPE2 was significantly increased in PBMCs from T2DM patients compared with those from healthy controls and was negatively correlated with serum TNF-α, IL-6, and hsCRP concentrations but positively correlated with HbA1c and LDL-C in T2DM patients. High glucose treatment (50 mmol/L) can upregulate the expression of TIPE2 and cytokine secretion in differentiated THP-1 cells. siTIPE2 infection exacerbated the increased TNF-α and IL-6 concentrations in differentiated THP-1 cells under high glucose conditions (50 mmol/L), while infection with TIPE2 adenovirus reversed the increased TNF-α concentration. Conclusions. The present study indicates that TIPE2 may participate in T2DM by regulating TNF-α production.

scholarly journals Rapid Genotyping for Tumor Necrosis Factor-α (TNF-α) −863C/A Promoter Polymorphism That Determines TNF-α Response

2004 ◽  
Vol 50 (1) ◽  
pp. 226-228 ◽  
Author(s):  
Michael Heesen ◽  
Dagmar Kunz ◽  
Martina Wessiepe ◽  
Tom van der Poll ◽  
Aeilko H Zwinderman ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Promoter Polymorphism ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor
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