Liver transaminase levels after intraportal autologous islet transplantation after partial pancreatectomy were associated with long-term metabolic outcomes

Islet transplantation holds renewed promise as a cure for type I diabetes mellitus. Results of recent clinical trials have shown remarkable success, and have reignited universal optimism for this procedure. In spite of this success, the need for life–long immunosuppression of the recipient still limits islet transplantation to patients with poorly controlled diabetes or to those requiring kidney transplantation. It is obvious that the achievement of immunological tolerance would broaden the indication for islet transplantation to a much larger cohort of patients with type I diabetes mellitus, most likely preventing long–term complications and contributing to a much improved quality of life. Increased understanding of the basic mechanisms of tolerance induction has resulted in the implementation of numerous experimental approaches to achieve long–term survival of islet grafts in the absence of chronic immunosuppression. In this brief review we will attempt to summarize the current status of research and knowledge.

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Endocrine Function and Metabolic Outcomes in Pancreas and Islet Transplantation

Transplantation of the Pancreas ◽

10.1007/978-1-4757-4371-5_15 ◽

2004 ◽

pp. 441-454 ◽

Cited By ~ 2

Author(s):

R. Paul Robertson

Keyword(s):

Islet Transplantation ◽

Endocrine Function ◽

Metabolic Outcomes

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Pancreatectomy and Autologous Islet Transplantation for Painful Chronic Pancreatitis: Indications and Outcomes

Hospital Practice ◽

10.3810/hp.2012.08.992 ◽

2012 ◽

Vol 40 (3) ◽

pp. 80-87 ◽

Cited By ~ 13

Author(s):

Melena D. Bellin ◽

David E. R. Sutherland ◽

R. Paul Robertson

Keyword(s):

Chronic Pancreatitis ◽

Islet Transplantation ◽

Autologous Islet Transplantation

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Abstract P120: Association Of Liver Transaminase Levels And Long-term Blood Pressure Variability In Military Young Males In Taiwan

Hypertension ◽

10.1161/hyp.76.suppl_1.p120 ◽

2020 ◽

Vol 76 (Suppl_1) ◽

Author(s):

Gen-min Lin ◽

Pang-yen Liu

Keyword(s):

Blood Pressure ◽

Lower Risk ◽

Blood Pressure Variability ◽

Smoking Status ◽

Linear Regression Analysis ◽

Elevated Serum ◽

Young Male ◽

Liver Transaminase ◽

Young Males

Background: Elevated serum liver transaminases (AST and ALT), highly related to metabolic disorders, are paradoxically associated with lower risk of cardiovascular disease (CVD) and mortality. Blood pressure variability (BPV), a risk factor of CVD, has not been examined the relationship with serum liver transaminase. Methods: A prospective cohort of 1,112 military males, aged 32.2 years was collected in Taiwan. Serum AST and ALT were obtained from a 12 hour-fast blood sample of each participant. BPV was assessed by standard deviation (SD) and average real variability (ARV) of systolic and diastolic blood pressure (SBP and DBP), respectively across 4 visits during the study period (2012-14, 2014-15, 2015-16, and 2016-18). Multivariable linear regression analysis was used to determine the association adjusting for age, body mass index, SBP, DBP, lipid profiles, physical activity, alcohol and smoking status. Results: In the unadjusted model, serum ALT were positively correlated with SD DBP and ARV DBP (β (SE) =0.36 (0.16) and 0.24 (0.12), respectively), and so were AST (β= 0.19 (0.08) and 0.14 (0.06), respectively). However, all the associations were insignificant with adjustments. By contrast, the associations with systolic BPV were initially insignificant in the unadjusted model. With adjustments, serum ALT were negatively correlated with SD SBP and ARV SBP (β= -0.34 (0.16) and -0.24 (0.12), respectively) and so were AST (β= -0.14 (0.07) and -0.11 (0.06), respectively). Conclusion: Our findings suggest that liver transaminase levels were negatively correlated with long-term systolic BPV in young male adults, possibly accounting for the lower risk of CVD in previous studies.

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