Aim & Objective:
The objective of this retrospective study was to investigate the efficacy of adding
remogliflozin to current insulin glargine plus two oral drug i.e. metformin and teneligliptin therapy in poorly controlled
Indian type 2 diabetes.
Material and Methods:
173 study participants were initially selected from patient database who continued on their insulin
glargine or received an increased dose of insulin glargine along with other OHA based therapy (Group A) and 187 were
selected who had received remogliflozin (100 mg BD) (Group B) in addition to insulin glargine along with other OHA
based therapy. Glycated haemoglobin (HbA1c), total daily insulin dose, body weight, and the number of hypoglycemic
events were recorded at weeks 0, 12 and 24.
Result:
During the study, mean values of HbA1c, FBG and P2BG were significantly reduced in both groups. Insulin
requirements decreased from 45.8 ± 16.7 IU/day to 38.5 ± 13.5 IU/day (P < 0.001) and at week 24 even further decreased
to 29.5 ± 14.5 IU/Day . Twenty three patients in group B were able to cease insulin treatment altogether after 24 week
treatment. It has been observed to attain tight blood glucose control we need to increase insulin dose in group A from 45.5
± 16.5 IU/Day to 51.5 ± 14.5 at week 12 (P<0.01) and which further increased to 53.8 ± 12.8 IU/Day at week 24 (P<0.01).
Adding remogliflozin showed significant effect on blood pressure (P < 0.001) and weight reduction (P < 0.001). It has
been observed that 38% patients has achieves targeted HbA1c (≤7%) in group B where it was 22% in group A.
Conclusion:
Results demonstrate that in uncontrolled T2DM patients remogliflozin 100 mg BD can successfully lay a
foundation for prolonged good glycemic control. Early addition of remogliflozin with insulin glargine plus OHAs may be
an alternative compare to intensive up titration of insulin daily dose in people with uncontrolled T2DM.
Clinical Trial Registration Number: A 2358
