scholarly journals Draft genomes of Enterococcus faecium strains isolated from human feces before and after eradication therapy against Helicobacter pylori

Data in Brief ◽  
2018 ◽  
Vol 16 ◽  
pp. 511-514 ◽  
Author(s):  
Nikita A. Prianichnikov ◽  
Maja V. Malakhova ◽  
Vlad V. Babenko ◽  
Andrei K. Larin ◽  
Evgenii I. Olekhnovich ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Enterococcus Faecium ◽  
Eradication Therapy ◽  
Human Feces ◽  
Before And After

scholarly journals Analysis of the grade of esophagitis, chromendoscopical and histological findings of esophagus in patients with gastroesophageal reflux disease before and after the therapy

2010 ◽  
Vol 67 (12) ◽  
pp. 991-997
Author(s):  
Vesna Brzacki ◽  
Aleksandar Nagorni ◽  
Dragan Mihailovic ◽  
Suzana Raicevic-Sibinovic ◽  
Bojan Mladenovic
Keyword(s):  
Helicobacter Pylori ◽  
Gastroesophageal Reflux ◽  
Basal Cell ◽  
Reflux Disease ◽  
Eradication Therapy ◽  
Clinical Findings ◽  
Histological Findings ◽  
Cell Hyperplasia ◽  
Basal Cell Hyperplasia ◽  
Before And After

Background/Aim. The symptoms of gastroesophageal reflux desease (GERD) are among the most common complaints for which patients are indicated for visiting gastroenterologist. It occurs as a result of the effect made by gastric reflux contents that moves into the esophagus. The prevalence of all forms of GERD is 40%. The aim of this study was to analyze the grade of esophagitis, chromendoscopical and histological findings of esophagus in patients with GERD before and after the therapy. Methods. A prospective study included 90 patients with symptoms of GERD, divided into 2 groups depending on whether they had endoscopic signs of gastroezophageal reflux (group ERD), or not (group NERD). All the patients had esophagogastroduodenoscopy, chromoendoscopy staining, test for Helicobacter pylori and histological findings of the esophagus. In the patients with Helicobacter pylori infection eradication therapy was done. Results. Esophagitis-B level was present in most of the patients. Among the groups, roughly the same number responded to positive findings on chromoendoscopy. After the therapy, chromoendoscopy was significantly negative in both groups of the patients comparing to chromoendoscopy before the therapy (p = 0.00001). Multiplication and elongation of papilla, basal cell hyperplasia, vascular dilatation, increasing of mitotic activity and the presence of polymorphonuclear leukocyte cells were statistically more frequent histological findings in the group ERB compared to the group NERB. After the therapy, the patients in both groups had statistically less histological findings of appropriate esophageal parameters. Conclusion. Chromoendoscopy combined with the standard endoscopy increases the sensitivity and specificity for reflux disease. Histology in the reflux disease is associated with endoscopic and clinical findings so that the localization of taking biopsies and histological criteria of pathohistological changes must be clearly defined. Multiplication and elongation of papilla, basal cell hyperplasia and the presence of polymorphonuclear leukocytes are the most relevant criteria in the diagnosis NERD.

scholarly journals Impact of Helicobacter pylori Eradication Therapy on Platelet Counts in Patients With Chronic Idiopathic Thrombocytopenic Purpura

2015 ◽  
Vol 8 (7) ◽  
pp. 35 ◽  
Author(s):  
Mohamadreza Amiri
Keyword(s):  
Helicobacter Pylori ◽  
Platelet Count ◽  
Eradication Therapy ◽  
Current Treatment ◽  
Thrombocytopenic Purpura ◽  
Stool Antigen Test ◽  
Platelet Counts ◽  
Before And After ◽  
History Of ◽  
H Pylori

<p>This study was a before and after clinical evaluation of <em>Helicobacter pylori</em> eradication on platelet counts in a group of 23 patients with chronic Idiopathic (Autoimmune) thrombocytopenic purpura (CITP). <em>H. pylori </em>infection was identified in patients by a <sup>13</sup>C-urea breath test and confirmed by an <em>H. pylori</em> stool antigen test. Eradication was conducted in patients testing positive. Infected (<em>n</em> = 10) and uninfected (<em>n</em> = 13) patient groups did not differ with respect to age, gender, history of previous splenectomy, treatment with anti-D, current treatment with corticosteroids, or initial platelet count<strong>s</strong>. <em>H pylori</em> eradication was successful in eight infected CITP patients, with two patients not responsive to treatment. Compared to the uninfected group, patients in the infected group who responded to eradication therapy had significantly increased platelet counts after six months (56.2 ± 22.2 <em>vs.</em> 233 ± 85.6 ×10<sup>3</sup> million cells/L; <em>P </em>&lt; 0.01), whereas platelet counts in the non-responding patients and uninfected group did not differ after this period of time. <em>H. pylori</em> eradication promotes significant platelet count improvement in patients with CITP. Thus, all patients with CITP should be tested and treated for<em> H. pylori </em>infections.</p>

Analysis of the clinical course of chronic gastritis during the three-component treatment regimen of Helicobacter pylori with the inclusion of bismuthi trikalium dicitrate in the treatment

2021 ◽  
Vol 22 (1) ◽  
pp. 87-91
Author(s):  
A. L. Korkin ◽  
◽  
E. V. Khomets ◽  
S. V. Gasanova ◽  
◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Treatment Regimen ◽  
Chronic Gastritis ◽  
Statistical Significance ◽  
Eradication Therapy ◽  
Clinical Manifestations ◽  
Well Being ◽  
City Hospital ◽  
End Of Treatment ◽  
Before And After

Purpose: to evaluate the dynamics of clinical manifestations of the disease in patients with chronic gastritis during the three-component treatment regimen of Helicobacter pylori with the inclusion of bismuthi trikalium dicitrate in the treatment. Material and methods. 38 residents of the Khanty-Mansi Autonomous Okrug-Ugra with chronic gastritis associated with Helicobacter pylori were examined in the Budgetary Establishment «Raduzhninskaya City Hospital». The clinical manifestations of dyspepsia and other manifestations of gastrointestinal dysfunction in patients before and after triple therapy with bismuthi trikalium dicitrate were evaluated. Statistical data processing was carried out using the program Statistica’ 99 Edition (Statsoft). The statistical significance of differences in different treatment periods was assessed using the Pearson – χ2 consent test and the Fisher test. The results. Clinical manifestations of the disease in the examined patients were represented by direct (58-84%) and complementary manifestations of dyspepsia (34-55%), manifestations of intestinal (32%), esophageal dysfunction (42%) in the presence of changes in general well-being (58%). When conducting eradication therapy, regression of direct manifestations of dyspepsia and heartburn is significant by the end of the first week of treatment, complementary criteria of dyspepsia – at the end of treatment. Manifestations of intestinal dysfunction in the form of constipation and discomfort in the mouth regress only 1 week after the end of therapy. Conclusion. The persistence of dyspepsia in 18% of cases after the end of eradication therapy is associated with the absence of eradication of Helicobacter pylori in 5% of cases and the functional origin of dyspepsia in 13% of cases. In patients with functional dyspepsia, the preservation of a low assessment of well-being according to the SAN questionnaire was verified, and in 5% of cases, the preservation of initial diarrhea after eradication therapy of Helicobacter pylori.

scholarly journals Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication

Gut ◽  
2020 ◽  
Vol 69 (9) ◽  
pp. 1572-1580 ◽  
Author(s):  
Joseph J Y Sung ◽  
Olabisi Oluwabukola Coker ◽  
Eagle Chu ◽  
Chun Ho Szeto ◽  
Simson Tsz Yat Luk ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Intestinal Metaplasia ◽  
Inositol Phosphate ◽  
Eradication Therapy ◽  
Treated Group ◽  
Oral Bacteria ◽  
Microbial Interactions ◽  
Bacterial Taxonomy ◽  
Before And After ◽  
H Pylori

ObjectiveHelicobacter pylori is associated with gastric inflammation, precancerous gastric atrophy (GA) and intestinal metaplasia (IM). We aimed to identify microbes that are associated with progressive inflammation, GA and IM 1 year after H. pylori eradication.DesignA total of 587 H. pylori–positive patients were randomised to receive H. pylori eradication therapy (295 patients) or placebo (292 patients). Bacterial taxonomy was analysed on 404 gastric biopsy samples comprising 102 pairs before and after 1 year H. pylori eradication and 100 pairs before and after 1 year placebo by 16S rRNA sequencing.ResultsAnalysis of microbial sequences confirmed the eradication of H. pylori in treated group after 1 year. Principal component analysis revealed distinct microbial clusters reflected by increase in bacterial diversity (p<0.00001) after H. pylori eradication. While microbial interactions remained largely unchanged after placebo treatment, microbial co-occurrence was less in treated group. Acinetobacter lwoffii, Streptococcus anginosus and Ralstonia were enriched while Roseburia and Sphingomonas were depleted in patients with persistent inflammation 1 year after H. pylori eradication. A distinct cluster of oral bacteria comprising Peptostreptococcus, Streptococcus, Parvimonas, Prevotella, Rothia and Granulicatella were associated with emergence and persistence of GA and IM. Probiotic Faecalibacterium praustznii was depleted in subjects who developed GA following H. pylori eradication. Functional pathways including amino acid metabolism and inositol phosphate metabolism were enriched while folate biosynthesis and NOD-like receptor signalling decreased in atrophy/IM-associated gastric microbiota.ConclusionThis study identified that gastric microbes contribute to the progression of gastric carcinogenesis after H. pylori eradication.

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