Different combinations of growth factors for the tenogenic differentiation of bone marrow mesenchymal stem cells in monolayer culture and in fibrin-based three-dimensional constructs

2017 ◽  
Vol 95 ◽  
pp. 44-53 ◽  
Author(s):  
Marta Bottagisio ◽  
Silvia Lopa ◽  
Valentina Granata ◽  
Giuseppe Talò ◽  
Chiara Bazzocchi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Monolayer Culture ◽  
Three Dimensional ◽  
Tenogenic Differentiation ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo

2014 ◽  
Vol 33 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Koji Otabe ◽  
Hiroyuki Nakahara ◽  
Akihiko Hasegawa ◽  
Tetsuya Matsukawa ◽  
Fumiaki Ayabe ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Transcription Factor ◽  
Tenogenic Differentiation ◽  
Marrow Mesenchymal Stem Cells

scholarly journals The systemic influence of platelet-derived growth factors on bone marrow mesenchymal stem cells in fracture patients

BMC Medicine ◽  
2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Hiang Boon Tan ◽  
Peter V Giannoudis ◽  
Sally A Boxall ◽  
Dennis McGonagle ◽  
Elena Jones
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Marrow Mesenchymal Stem Cells

Bone augmentation by bone marrow mesenchymal stem cells cultured in three-dimensional biodegradable polymer scaffolds

2009 ◽  
Vol 91A (2) ◽  
pp. 428-435 ◽  
Author(s):  
Toshimitsu Tanaka ◽  
Motohiro Hirose ◽  
Noriko Kotobuki ◽  
Mika Tadokoro ◽  
Hajime Ohgushi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Biodegradable Polymer ◽  
Three Dimensional ◽  
Bone Augmentation ◽  
Polymer Scaffolds ◽  
Marrow Mesenchymal Stem Cells ◽  
Cells Cultured

scholarly journals BMP14 induces tenogenic differentiation of bone marrow mesenchymal stem cells in�vitro

2018 ◽  
Author(s):  
Dan Wang ◽  
Xinhao Jiang ◽  
Aiqing Lu ◽  
Min Tu ◽  
Wei Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Tenogenic Differentiation ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Three-dimensional spheroid culture of canine hepatocyte-like cells derived from bone marrow mesenchymal stem cells

2020 ◽  
Vol 15 ◽  
pp. 210-215
Author(s):  
Suguru Nitta ◽  
Masaharu Hisasue ◽  
Yu Horiguchi ◽  
Yoko Yamada ◽  
Kaoruko Kikuchi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Three Dimensional ◽  
Spheroid Culture ◽  
Marrow Mesenchymal Stem Cells

EVALUATION OF THREE DIMENSIONAL CONSTRUCT ENGINEERED FROM POLY(LACTIC-CO-GLYCOLIC ACID)/FIBRIN HYBRID SCAFFOLD USING RABBIT BONE MARROW MESENCHYMAL STEM CELLS FOR OSTEOCHONDRAL DEFECT REPAIR

2015 ◽  
Vol 77 (25) ◽  
Author(s):  
Rozlin Abdul Rahman ◽  
Norhamiza Mohamad Sukri ◽  
Noorhidayah Md Nazir ◽  
Muhammad Aa’zamuddin Ahmad Radzi ◽  
Ahmad Hafiz Zulkifly ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Glycolic Acid ◽  
Osteochondral Defect ◽  
Rabbit Model ◽  
Three Dimensional ◽  
Marker Genes ◽  
Repair Capacity ◽  
Marrow Mesenchymal Stem Cells

Articular cartilage has poor repair capacity due to its avascular and aneural properties and has relatively few cells. This study investigated the ability of autologous implantation approach using three dimensional (3D) constructs engineered from bone marrow mesenchymal stem cells (BMSCs) seeded on poly(lactic-co-glycolic acid) (PLGA) with or without fibrin as cells carrier for the repair of osteochondral defect in rabbit model. The engineered 3D constructs – PLGA/Fibrin/BMSCs and PLGA/BMSCs – were cultured for 3 weeks in vitro and implanted autologously to the osteochondral defect created in the rabbit knee. The in vivo constructs were harvested and evaluated by means of gross observation, histology assessment, gene expression study, sulphated glycosaminoglycan (sGAG) production assay and biomechanical evaluation at 6 and 12 weeks post implantation. The results showed that the osteochondral defects treated with the PLGA/Fibrin/BMSCs constructs exhibited better repairment, more cartilaginous extracellular matrix, higher sGAG production, superior compressive strength and more intense expression of chondrogenic marker genes than the PLGA/BMSCs group. This study suggested that the PLGA/Fibrin/BMSCs has the potential to treat osteochondral defect and may be presented as a viable therapeutic option for those who would be in need from the life-extending benefits of tissue replacement or repair.

Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three‐dimensional layered scaffold

2017 ◽  
Vol 12 (2) ◽  
pp. 360-369 ◽  
Author(s):  
Jessica Schiavi ◽  
Loïc Reppel ◽  
Naceur Charif ◽  
Natalia Isla ◽  
Didier Mainard ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Three Dimensional ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Marrow Mesenchymal Stem Cells
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