13C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer®): Toward standardization for testing gastric emptying of solids

2010 ◽  
Vol 42 (8) ◽  
pp. 549-553 ◽  
Author(s):  
Francesco Perri ◽  
Massimo Bellini ◽  
Piero Portincasa ◽  
Andrea Parodi ◽  
Patrizia Bonazzi ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Test Meal ◽  
Breath Test ◽  
Octanoic Acid

Gastric emptying flow curves separated from carbon-labeled octanoic acid breath test results

1998 ◽  
Vol 275 (1) ◽  
pp. G169-G175 ◽  
Author(s):  
B. D. Maes ◽  
G. Mys ◽  
B. J. Geypens ◽  
P. Evenepoel ◽  
Y. F. Ghoos ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Test Meal ◽  
Breath Test ◽  
Octanoic Acid ◽  
Lag Phase ◽  
Test Results ◽  
Flow Curves ◽  
Mean Values ◽  
Good Agreement ◽  
Emptying Time

Recently, we developed the [13/14C]octanoic acid breath test to measure gastric emptying of solids. Although the method has been validated extensively, absorption, metabolism, and excretion of the label in the breath need to be corrected for. In this study a mathematical model was developed that allows for 1) separation of the global CO2 excretion after ingestion of the labeled test meal into the emptying rate of the labeled test meal from mouth to pylorus and the postgastric processing of absorption, metabolism, and excretion of the label, and 2) numerical calculation of the half-emptying time and lag phase of the emptied meal. The model was applied to the gastric emptying results obtained by simultaneous scintigraphic and breath test measurements. An excellent correlation was found between the gastric half-emptying time ( r = 0.98) and lag phase ( r = 0.85) determined scintigraphically and via breath test. There was also a good agreement between the two methods [mean values and confidence limits for differences: t ½= 10 min (−20 to 41) and t lag = −3 min (−39 to 34)]. Moreover, the separated gastric emptying curves, lacking the influence of postgastric processing of the label, showed real patterns of gastric outflow, which changes from moment to moment.

Effect of body size on gastric emptying using the 13C-octanoic acid breath test

2004 ◽  
Vol 45 (8) ◽  
pp. 386-389 ◽  
Author(s):  
P. S. Yam ◽  
J. McLellan ◽  
C. Wyse ◽  
S. W. J. Reid ◽  
J. Cooper ◽  
...  
Keyword(s):  
Body Size ◽  
Gastric Emptying ◽  
Breath Test ◽  
Octanoic Acid

A study of gastric emptying in H. pylori negative healthy volunteers using the 13C-octanoic acid breath test

2000 ◽  
Vol 118 (4) ◽  
pp. A1169 ◽  
Author(s):  
Shigeyuki Ebara ◽  
Nobuo Aoyama ◽  
Toshiyuki Sakai ◽  
Takahiro Ikemura ◽  
Daisuke Shirasaka ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Breath Test ◽  
Octanoic Acid ◽  
H Pylori

The 13C-octanoic acid breath test: validation of a new noninvasive method of measuring gastric emptying in rats

2002 ◽  
Vol 14 (3) ◽  
pp. 287-293 ◽  
Author(s):  
R. Schoonjans ◽  
B. Van Vlem ◽  
N. Van Heddeghem ◽  
W. Vandamme ◽  
R. Vanholder ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Breath Test ◽  
Octanoic Acid ◽  
Test Validation ◽  
Noninvasive Method

The ratio of 13 CO 2 exhalation at 120 min to 13 CO 2 exhalation at 60 min as a simpler gastric emptying parameter in the 13 C-octanoic acid breath test: a preliminary study

2003 ◽  
Vol 38 (3) ◽  
pp. 298-299 ◽  
Author(s):  
Masaki Sanaka ◽  
Takatsugu Yamamoto ◽  
Yasushi Kuyama ◽  
Yuko Shimomura ◽  
Kengo Hattori ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Breath Test ◽  
Octanoic Acid ◽  
Preliminary Study

The 13C-Octanoic Acid Breath Test: A Noninvasive Technique to Assess Gastric Emptying in Preterm Infants

1996 ◽  
Vol 23 (2) ◽  
pp. 111-117 ◽  
Author(s):  
G. Veereman-Wauters ◽  
Y. Ghoos ◽  
S. van der Schoor ◽  
B. Maes ◽  
N. Hebbalkar ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Preterm Infants ◽  
Breath Test ◽  
Octanoic Acid ◽  
Noninvasive Technique

61 THE 13C OCTANOIC ACID BREATH TEST FOR ASSESSMENT OF GASTRIC EMPTYING IN PRETERM INFANTS

1995 ◽  
Vol 20 (4) ◽  
pp. 460
Author(s):  
S. vd Schoor ◽  
G. Veereman-Wauters ◽  
K. van Aalst ◽  
Y. F. Ghoos ◽  
N. Hebbalkar ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Preterm Infants ◽  
Breath Test ◽  
Octanoic Acid
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