Aggregation-induced emission with enhanced two-photon absorption of dicyanomethylene-benzopyran with polyether chain for blood-brain barrier penetration

2020 ◽  
Vol 172 ◽  
pp. 107827 ◽  
Author(s):  
Jiejie Liu ◽  
Dandan Liu ◽  
Yu Shen ◽  
Mingzhu Zhang ◽  
Tianyan Liu ◽  
...  
2017 ◽  
Vol 1 (7) ◽  
pp. 1396-1405 ◽  
Author(s):  
Ji Yang ◽  
Yuting Gao ◽  
Tao Jiang ◽  
Wen Liu ◽  
Chenchen Liu ◽  
...  

Non-substituted and alkyl-substituted triphenylamine–dibenzo[a,c]phenazine adducts (Q1–Q3) showed the combined features of ICT plus AEE, while the alkoxy-substituted Q4–Q5 exhibited obvious AIE effects.


2017 ◽  
Vol 20 ◽  
pp. 161 ◽  
Author(s):  
Qing Wang ◽  
Si Chen ◽  
Yan-Gang Zhou ◽  
Ping Xu ◽  
Yi-Ping Liu ◽  
...  

PURPOSE: This study investigated the association between vancomycin blood brain barrier penetration and clinical response in patients with postsurgical meningitis. METHODS: Adult patients with postsurgical meningitis were recruited. Eligible patients received vancomycin 500 mg every 6 h for at least 5 days. On day 3 or 4, cerebrospinal fluid (CSF) and simultaneous serum samples were obtained to determine CSF minimum concentrations (Cmin), serum Cmin and CSF to serum Cmin ratio. RESULTS: Twenty-two patients (14 men and 8 women; mean age of 52.6± 12.1 years) were recruited. The vancomycin Cmin was 3.63 ± 1.64 mg/L in CSF and 13.38 ± 5.36 mg/L in serum, with the CSF to serum Cmin ratio of 0.291 ± 0.118. The Cmin in serum and in CSF showed a significant correlation (p=0.005, r =0.575). The vancomycin CSF Cmin had a significant correlation with the decline of white blood cell counts (WBCs) in CSF (p=0.003, r =0.609). CSF Cmin, serum Cmin and CSF to serum Cmin ratio all showed no significant correlation with clinical response (p=0.335, 0.100, 0.679, respectively). CONCLUSIONS: There was a positive correlation between serum Cmin and CSF Cmin. However, only CSF Cmin is positively correlated with WBCs improvement in CSF. All other parameters such as serum Cmin, CSF Cmin and CSF to serum Cmin ratio had no correlation with clinical response. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.


2020 ◽  
Vol 432 (14) ◽  
pp. 3989-4009 ◽  
Author(s):  
Zachary R. Crook ◽  
Emily Girard ◽  
Gregory P. Sevilla ◽  
Morgan Merrill ◽  
Della Friend ◽  
...  

2008 ◽  
Vol 22 (6-7) ◽  
pp. 431-440 ◽  
Author(s):  
Olga Obrezanova ◽  
Joelle M. R. Gola ◽  
Edmund J. Champness ◽  
Matthew D. Segall

Small ◽  
2018 ◽  
Vol 14 (6) ◽  
pp. 1870024 ◽  
Author(s):  
Attilio Marino ◽  
Omar Tricinci ◽  
Matteo Battaglini ◽  
Carlo Filippeschi ◽  
Virgilio Mattoli ◽  
...  

2020 ◽  
Vol 11 (12) ◽  
pp. 1801-1810
Author(s):  
Ji-Woo Choi ◽  
Yeon Ha Ju ◽  
Yunsook Choi ◽  
Seung Jae Hyeon ◽  
Changdev G. Gadhe ◽  
...  

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