scholarly journals Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia

EBioMedicine ◽  
2020 ◽  
Vol 54 ◽  
pp. 102678
Author(s):  
K.M. Kampa-Schittenhelm ◽  
T. Haverkamp ◽  
M. Bonin ◽  
V. Tsintari ◽  
H.J. Bühring ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Acetylglucosamine Transferase

Defective Fibrin Crosslinking in Acute Leukemia

1984 ◽  
Vol 52 (03) ◽  
pp. 343-346 ◽  
Author(s):  
F Rodeghiero ◽  
T Barbui ◽  
A Dal Belin-Peruffo ◽  
E Dini
Keyword(s):  
Acute Leukemia ◽  
Factor Xiii ◽  
Factor Xiii Deficiency ◽  
Coagulation Abnormalities ◽  
Normal Plasma ◽  
Transamidating Activity

SummaryFibrin crosslinking was assayed in 22 patients with acute leukemia showing secondary coagulation abnormalities of variable severity. In 9 patients fibrin crosslinking was found to be normal, whereas 10 patients presented impaired polymerization of α-chains and 3 of both α- and γ-chains.Only a rough correlation was found between transamidating activity of factor XIII and the fibrin crosslinking pattern in these patients. Moreover, incomplete fibrin crosslinkage occurred at levels of factor XIII far in excess of that required for full polymerization of fibrin in “normal” plasma. This latter finding suggests that, in addition to factor XIII deficiency, other causes are responsible for thehigh rate of fibrin crosslinking impairment in acute leukemia.

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