scholarly journals Extrapulmonary sarcoidosis with a focus on cardiac, nervous system, and ocular involvement

2021 ◽  
Vol 37 ◽  
pp. 100966
Author(s):  
John A. Belperio ◽  
Faisal Shaikh ◽  
Fereidoun Abtin ◽  
Michael C. Fishbein ◽  
Rajan Saggar ◽  
...  
Keyword(s):  
Nervous System ◽  
Ocular Involvement

scholarly journals A CASE OF DISSEMINATED TUBERCULOSIS WITH OCULAR INVOLVEMENT

2015 ◽  
Vol 05 (01) ◽  
pp. 094-096
Author(s):  
Md Fekarul Islam ◽  
Devdeep Mukherjee ◽  
Ritabrata Kundu ◽  
Prabal Chandra Niyogi ◽  
Joydeep Das
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Corneal Opacity ◽  
Ocular Involvement ◽  
Disseminated Tuberculosis ◽  
Ocular Manifestations ◽  
The Central Nervous System ◽  
Immunocompromised State ◽  
Ocular Tb ◽  
Posterior Synechiae

AbstractDisseminated Tuberculosis (DTB) refers to tubercular involvement of two or more non-contiguous sites and is commonly associated with immunocompromised state. It is an unusual presentation of Tuberculosis (TB), especially in the absence of immunodeficiency. 1.4% of patients with Pulmonary Tuberculosis (PTB) develop ocular manifestations but many patients with ocular TB have no evidence of PTB. Tuberculosis can cause a wide variety of ophthalmic findings, ranging from the ocular surface through the optic nerve and to the central nervous system. In this article, we report a case of Disseminated Tuberculosis with ocular involvement in a 5years old female. Our case is unique for the presence of bilateral squint, unilateral nebular type of corneal opacity, bilateral iritis with posterior synechiae and cataract at the same time. It lays emphasis on the fact that a patient with tuberculosis should be screened for multiple foci.

scholarly journals Multiple Sclerosis Revealed by Anterior Uveitis

2020 ◽  
Vol 2 (5) ◽  
Author(s):  
Sidi Dahi ◽  
Mehdi Khamaily ◽  
Joumany Brahim Salem ◽  
Imane Tarib ◽  
Mounia Bouchaar ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Inflammatory Disease ◽  
Anterior Uveitis ◽  
Oculomotor Nerve ◽  
Ocular Involvement ◽  
Atypical Case ◽  
Autoimmune Inflammatory Disease ◽  
The Central Nervous System

Multiple sclerosis is an autoimmune inflammatory disease of the central nervous system, leading to the formation of foci of demyelination. Ocular involvement is quite frequent and multiple, dominated by inflammatory optic neuropathies, oculomotor nerve damage, nystagmus and uveitis. We report an atypical case of multiple sclerosis revealed by an anterior unilateral synechiatic hypertensive uveitis in a young patient of 27 years.

scholarly journals LINC-33. MULTIMODALITY MANAGEMENT OF PAEDIATRIC PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA- UPDATED EXPERIENCE FROM A REGIONAL CANCER CENTRE IN NORTH INDIA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii385-iii385
Author(s):  
Ahitagni Biswas ◽  
Swarnaditya Roy ◽  
Yousra KN ◽  
Sameer Bakhshi ◽  
Vaishali Suri ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Single Agent ◽  
Central Nervous System Lymphoma ◽  
North India ◽  
High Dose ◽  
Ocular Involvement ◽  
Csf Cytology ◽  
Whole Brain ◽  
Female Ratio

Abstract Paediatric primary central nervous system lymphoma(PCNSL) constitutes 1% of all PCNSLs. Data pertaining to paediatric PCNSL (2016–19) was abstracted by retrospective chart review. We identified 7 paediatric patients with PCNSL. None had congenital or acquired immunodeficiency. The median age at presentation was 13 years. The male to female ratio was 4:3. The median ECOG performance status was 2. On neuro-imaging, 3 patients had solitary and 4 patients had multiple lesions. CSF cytology showed atypical cells in 1 patient. None had ocular involvement. Systemic lymphoma work-up was negative in all. Biopsy and resection of tumour were done in 4 patients each. Histopathology revealed DLBCL in 6 and B-cell NHL in 1 patient. All patients underwent induction chemotherapy (median-5 cycles)- modified DeAngelis protocol (IV Methotrexate-2.5g/m2,IT Methotrexate-12 mg,Vincristine,Procarbazine and Rituximab-375mg/m2 every 2 weeks) in 6 and single agent Methotrexate -3.5g/m2 every 3 weeks in 1 patient. Severe haematological toxicities included grade 3 neutropenia, leucopenia and febrile neutropenia in 2,1 and 1 patient respectively. Radiotherapy(RT) was administered in all-whole brain RT(36-45Gy/20-25fractions/4-5weeks) in 6 patients and craniospinal RT(36Gy/18fractions/3.5weeks) followed by whole brain RT(9Gy/5fractions/1week) in 1 patient(with positive CSF cytology). Subsequently consolidation chemotherapy with 2 cycles of Cytarabine(3g/m2 IV D1-2 every 3 weeks) was administered in 5 patients. After a median follow-up of 14 months(mean-18.2 months), all patients are in complete radiological remission. Paediatric PCNSL is a rare tumour entity and multimodality management with high dose Methotrexate and Rituximab based chemo-immunotherapy and cranial radiotherapy leads to excellent early clinical outcome.

scholarly journals Evaluating optical coherence tomography (OCT) findings as potential biomarkers in central nervous system (CNS) lymphoma with or without ocular involvement

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Muhammad Hassan ◽  
Muhammad Sohail Halim ◽  
Rubbia Afridi ◽  
Nam V. Nguyen ◽  
Quan Dong Nguyen ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Optical Coherence Tomography ◽  
Nervous System ◽  
Ocular Disease ◽  
Ocular Involvement ◽  
Optical Coherence ◽  
Ellipsoid Zone ◽  
Intraretinal Fluid ◽  
Group 2 ◽  
Group 1

Abstract Background To evaluate spectral domain optical coherence tomography (SD-OCT) findings as biomarkers in primary central nervous system lymphoma (PCNSL) with or without ocular involvement. Methods This study was a cross-sectional study and patients with a confirmed diagnosis of PCNSL with or without ocular involvement were included. Patient cohort finder tool was used to identify patients with lymphoma using ICD-10 codes (C82–C88), from January 2004 to October 2017. A total of 14,820 patients were identified. Procedure code (92134) for optical coherence tomography (OCT) was then applied to identify patients who had underdone OCT imaging at ophthalmology clinic. Clinic charts of 460 patients with lymphoma and available OCT were reviewed to identify patients with confirmed diagnosis of PCNSL and divided into two groups (Group 1: with and Group 2: without ocular involvement). OCT scans of patients in both study groups were analyzed for the presence of (1) Hyperreflective deposits in choroid, retinal pigment epithelium (RPE), outer and inner retina; (2) RPE thickening; (3) Vitreous debris; (4) Intraretinal fluid; (5) Ellipsoid zone disruption by masked graders. Chi-square was used to analyze the difference between the groups. Results Twenty-two eyes (11 patients) with PCNSL were included this study (Group 1: 6 eyes and Group 2: 16 eyes). Mean age of subjects was 65 years. Five patients (45.45%) were female. There was no statistically significant difference between the groups for the presence of hyperreflective deposits in choroid, RPE, outer and inner retina, and presence of RPE thickening, intraretinal fluid, and ellipsoid zone disruption. Vitreous debris was found more commonly in group 1 subjects (83%) than group 2 (31.25%) (p = 0.029). All subjects in both groups showed hyperreflective deposits in the RPE demonstrating RPE infiltration. However, RPE thickening was noted only in 3 patients (Group1: 1 and Group2: 2). Conclusions OCT finding of hyperreflective deposits present in eyes with lymphoma secondary to PCNSL are also observed in eyes with PCNSL without ocular disease. However, the vitreous deposits are more commonly found in eyes with ocular disease. These hyperreflective deposits can serve as biomarkers for early detection of ocular involvement by PCNSL.

OPHTHALMIC, ULTRASONOGRAPHIC FINDINGS IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA WITH OCULAR INVOLVEMENT

Retina ◽  
1997 ◽  
Vol 17 (2) ◽  
pp. 118-123 ◽  
Author(s):  
ROXANA URSEA ◽  
MURKHEIN HEINEMANN ◽  
RONALD H. SILVERMAN ◽  
LISA M. DEANGELIS ◽  
SUZANNE W. DALY ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Lymphoma ◽  
Ocular Involvement
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