Psychometric validation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24)

2011 ◽  
Vol 47 (2) ◽  
pp. 183-190 ◽  
Author(s):  
Elfriede Greimel ◽  
Andy Nordin ◽  
Anne Lanceley ◽  
Carien L. Creutzberg ◽  
Lonneke V. van de Poll-Franse ◽  
...  
2010 ◽  
Vol 46 (12) ◽  
pp. 2242-2252 ◽  
Author(s):  
Colin Johnson ◽  
Deborah Fitzsimmons ◽  
Jacqueline Gilbert ◽  
Juan-Ignacio Arrarras ◽  
Eva Hammerlid ◽  
...  

2019 ◽  
Vol 45 (4) ◽  
Author(s):  
Ana Paula Ramos Marinho ◽  
Gracielle Fin ◽  
Antuani Rafael Baptistella ◽  
Rudy José Nodari Júnior ◽  
Magnus Benetti

ABSTRACT Objective: To translate the European Organisation for Research and Treatment of Cancer (EORTC) 29-item Quality of Life Questionnaire-Lung Cancer Module (QLQ-LC29, developed for the assessment of quality of life in patients with lung cancer) to Portuguese, conducting a pilot study of the Portuguese-language version and adapting it for use in Brazil. Methods: For the translation, cultural adaptation, and pilot testing of the QLQ-LC29, we followed the guidelines established by the EORTC. The translation (English → Portuguese) and back-translation (Portuguese → English) were both carried out by translators, working independently, who were native speakers of one language and fluent in the other. After review, a draft version was created for pilot testing in lung cancer patients in Brazil. Results: A total of 15 patients diagnosed with lung cancer completed the Portuguese-language version of the questionnaire. At the end of the process, we conducted a structured interview to identify any patient difficulty in understanding any of the questions. The final versions were sent to the EORTC and were approved. Conclusions: The Portuguese-language version of the EORTC QLQ-LC29 appears to be a useful, important, reliable questionnaire that is a valid tool for assessing quality of life in patients with lung cancer in Brazil.


2018 ◽  
Vol 154 (6) ◽  
pp. S-1353-S-1354
Author(s):  
Dakshitha Wickramasinghe ◽  
Praveen V. Dayasena ◽  
Pragathi L. Weerakkody ◽  
Sanjeewa Seneviratne ◽  
Dharmabandhu N. Samarasekera

2015 ◽  
Vol 2 (1) ◽  
pp. 34-35

Hintergrund: Tumorassoziierte Schmerzen treten bei ambulanten Patientinnen mit metastasiertem Brustkrebs mit hoher Prävalenz auf und beeinträchtigen ihre gesundheitsbezogene Lebensqualität (gLQ). In dieser Studie wurden potenzielle Auswirkungen einer umfassenden medikamentösen Tumorschmerz-Therapie (TST) auf die gLQ untersucht.Patientinnen und Methoden: 52 ambulante Patientinnen mit metastasiertem Brustkrebs unter palliativer Chemotherapie nahmen an der Studie teil. 28 Patientinnen, die an mittelschweren bis schweren Krebsschmerzen litten, wurde eine TST angeboten. 13 dieser Patientinnen nahmen das Angebot an (Interventionsgruppe), 15 lehnten es ab (Kontrollgruppe). Die Beurteilung der gLQ erfolgte anhand des Quality of Life Questionnaire «EORTC QLQ-C30» (EORTC = European Organisation for Research and Treatment of Cancer) sowie des Brustkrebs-spezifischen Moduls «QLQ-BR23» zu Studienbeginn und nach 3 Wochen.Ergebnisse: Bei Studienbeginn klagten 83% der Patientinnen über krebsbedingte Schmerzen, wobei 35% von ihnen keine verschriebenen Schmerzmittel einnahmen. Die gLQ aller Patientinnen war im Vergleich zu den Referenz-Scores herabgesetzt. Nach der TST berichtete die Interventionsgruppe über signifikant gelinderte Schmerzen und Verbesserungen bei mehreren gLQ-Subskalen (allgemeine LQ, emotionale Funktionsfähigkeit, physische Funktionsfähigkeit, Zukunftsperspektiven, Schlaflosigkeit). Bei der Kontrollgruppe waren keine signifikanten Veränderungen zu verzeichnen.Schlussfolgerung: Diese Studie unterstreicht den Bedarf an adäquater Schmerztherapie bei palliativ behandelten ambulanten Brustkrebs-Patientinnen. Die Kombination aus TST als Richtschnur für die pharmakologische Seite des Tumorschmerz-Managements einerseits und dem «EORTC QLQ-C30» als Instrument für die Untersuchung und Überwachung andererseits erscheint als Ansatz, der weiterführende Untersuchungen verdient.Übersetzung aus Oncol Res Treat 2014;37:456-462 (DOI: 10.1159/000365537)


2004 ◽  
Vol 22 (15) ◽  
pp. 3172-3180 ◽  
Author(s):  
Anna K. Nowak ◽  
Martin R. Stockler ◽  
Michael J. Byrne

Purpose To assess the feasibility and validity of using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30) and Lung Cancer Module (QLQ-LC13) to describe health-related quality of life (HRQL) in patients with pleural mesothelioma undergoing combination chemotherapy, to identify the most impaired aspects of HRQL, and to assess the impact of chemotherapy on HRQL. Patients and Methods Fifty-three patients received cisplatin on day 1 and gemcitabine on days 1, 8, and 15 of a 28-day cycle for a maximum of six cycles. HRQL was assessed using the EORTC QLQ-C30 and QLQ-LC13. Results Compliance was 100% at baseline but subsequently decreased. At baseline, role function and social function were the most impaired domains, and the worst-rated symptoms were fatigue, dyspnea, pain, insomnia, appetite loss, and cough. Dyspnea, pain, insomnia, and cough improved with chemotherapy, although functional domains and chemotherapy-related symptoms deteriorated. Fatigue remained unchanged. Few patients reported hemoptysis. Functional domains and symptoms scales from the QLQ-C30 demonstrated predictive validity for survival. The predictive value of QLQ-LC13 pain scores was improved by combining three pain items into a single score. Dyspnea scores were correlated strongly with lung function as measured by forced vital capacity. Conclusion This study supports the validity of the EORTC QLQ-C30 and LC13 as outcome measures for trials of chemotherapy in mesothelioma. Although the most prominent symptoms reported were concordant with clinical experience, impairments in role and social function and insomnia were worse than expected. Future research should focus on how best to apply, analyze, and interpret existing, validated HRQL instruments in mesothelioma research and practice, not on the development of new ones.


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