Combination of shear wave elastography and Ki-67 index as a novel predictive modality for the pathological response to neoadjuvant chemotherapy in patients with invasive breast cancer

2016 ◽  
Vol 69 ◽  
pp. 86-101 ◽  
Author(s):  
Yan Ma ◽  
Shuo Zhang ◽  
Li Zang ◽  
Jing Li ◽  
Jianyi Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Shear Wave ◽  
Invasive Breast Cancer ◽  
Shear Wave Elastography ◽  
Pathological Response ◽  
Ki 67 ◽  
Response To Neoadjuvant Chemotherapy

scholarly journals Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Juanjuan Gu ◽  
Eric C. Polley ◽  
Max Denis ◽  
Jodi M. Carter ◽  
Sandhya Pruthi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Shear Wave ◽  
Invasive Breast Cancer ◽  
Shear Wave Elastography ◽  
Early Prediction ◽  
Early Assessment ◽  
Significant Difference ◽  
Mass Size ◽  
Response To Neoadjuvant Chemotherapy

Abstract Background Early prediction of tumor response to neoadjuvant chemotherapy (NACT) is crucial for optimal treatment and improved outcome in breast cancer patients. The purpose of this study is to investigate the role of shear wave elastography (SWE) for early assessment of response to NACT in patients with invasive breast cancer. Methods In a prospective study, 62 patients with biopsy-proven invasive breast cancer were enrolled. Three SWE studies were conducted on each patient: before, at mid-course, and after NACT but before surgery. A new parameter, mass characteristic frequency (fmass), along with SWE measurements and mass size was obtained from each SWE study visit. The clinical biomarkers were acquired from the pre-NACT core-needle biopsy. The efficacy of different models, generated with the leave-one-out cross-validation, in predicting response to NACT was shown by the area under the receiver operating characteristic curve and the corresponding sensitivity and specificity. Results A significant difference was found for SWE parameters measured before, at mid-course, and after NACT between the responders and non-responders. The combination of Emean2 and mass size (s2) gave an AUC of 0.75 (0.95 CI 0.62–0.88). For the ER+ tumors, the combination of Emean_ratio1, s1, and Ki-67 index gave an improved AUC of 0.84 (0.95 CI 0.65–0.96). For responders, fmass was significantly higher during the third visit. Conclusions Our study findings highlight the value of SWE estimation in the mid-course of NACT for the early prediction of treatment response. For ER+ tumors, the addition of Ki-67improves the predictive power of SWE. Moreover, fmass is presented as a new marker in predicting the endpoint of NACT in responders.

scholarly journals Can shear-wave elastography predict response to neoadjuvant chemotherapy in women with invasive breast cancer?

2013 ◽  
Vol 109 (11) ◽  
pp. 2798-2802 ◽  
Author(s):  
A Evans ◽  
S Armstrong ◽  
P Whelehan ◽  
K Thomson ◽  
P Rauchhaus ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Shear Wave ◽  
Invasive Breast Cancer ◽  
Shear Wave Elastography ◽  
Response To Neoadjuvant Chemotherapy

scholarly journals Tumor‐stroma ratio is associated with Miller‐Payne score and pathological response to neoadjuvant chemotherapy in HER2‐negative early breast cancer.

2021 ◽  
Author(s):  
Sophie C. Hagenaars ◽  
Stefanie Groot ◽  
Danielle Cohen ◽  
Tim J.A. Dekker ◽  
Ayoub Charehbili ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Early Breast Cancer ◽  
Tumor Stroma ◽  
Pathological Response ◽  
Response To Neoadjuvant Chemotherapy
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