scholarly journals D-dimer testing after anticoagulant discontinuation to predict recurrent venous thromboembolism

2021 ◽  
Author(s):  
Stefano Barco ◽  
Frederikus A Klok
Keyword(s):  
Venous Thromboembolism ◽  
Recurrent Venous Thromboembolism ◽  
D Dimer

Diagnostic accuracy of D-Dimer testing for recurrent venous thromboembolism: A systematic review with meta-analysis.

2021 ◽  
Author(s):  
Matteo Nicola Dario Di Minno ◽  
Ilenia Calcaterra ◽  
Antimo Papa ◽  
Roberta Lupoli ◽  
Alessandro Di Minno ◽  
...  
Keyword(s):  
Systematic Review ◽  
Venous Thromboembolism ◽  
Diagnostic Accuracy ◽  
Meta Analysis ◽  
Recurrent Venous Thromboembolism ◽  
D Dimer

Prospective assessment of the natural history of positive D-dimer results in persons with acute venous thromboembolism (DVT or PE)

2003 ◽  
Vol 89 (02) ◽  
pp. 284-287 ◽  
Author(s):  
John Kuruvilla ◽  
Phil Wells ◽  
Bev Morrow ◽  
Karen MacKinnon ◽  
Michael Keeney ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Natural History ◽  
Positive Result ◽  
Recurrent Events ◽  
Recurrent Venous Thromboembolism ◽  
Prospective Assessment ◽  
History Of ◽  
Acute Venous Thromboembolism ◽  
D Dimer

SummaryThe natural history of initially positive D-dimers for venous thromboembolism is not known. If it returns to negative in the majority of patients, it would be potentially helpful to diagnose a recurrence. In this study, we prospectively measured D-dimer levels in outpatients with a diagnosis of venous thrombo-embolism. There were a total of 152 patients with an average age of 57. D-dimer results were performed at baseline and repeated at one week, one month and three months.At baseline 120 of 152 (79%) had a positive D-dimer result. Of those with an initially positive result, 80% were still positive at one week and 39% were still positive at one month. Finally at three months, 13% remained positive. Seven patients had recurrent events and all had persistently elevated D-dimers at one month. This study suggests that a persistently positive D-dimer result after one month of treatment may indicate a higher risk of recurrent venous thromboembolism. D-dimer testing for the diagnosis of recurrence of venous thromboembolism deserves further study.

OC-14 - Baseline D-dimer levels are predictive of recurrent venous thromboembolism (VTE) at 6 months in cancer patients with VTE treated with tinzaparin

2016 ◽  
Vol 140 ◽  
pp. S174 ◽  
Author(s):  
C.I. Piatek ◽  
S.T. Tagawa ◽  
D. Wei-Tsai ◽  
D. Hanna ◽  
I.C. Weitz ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Cancer Patients ◽  
Recurrent Venous Thromboembolism ◽  
D Dimer

Prediction of Recurrent Venous Thromboembolism by Endogenous Thrombin Potential and D-Dimer

2008 ◽  
Vol 54 (12) ◽  
pp. 2042-2048 ◽  
Author(s):  
Sabine Eichinger ◽  
Gregor Hron ◽  
Marietta Kollars ◽  
Paul A Kyrle
Keyword(s):  
Venous Thromboembolism ◽  
Thrombin Generation ◽  
Factor V Leiden ◽  
Study Endpoint ◽  
Factor V ◽  
Risk Of Recurrence ◽  
Endogenous Thrombin Potential ◽  
Increased Risk ◽  
Recurrent Venous Thromboembolism ◽  
D Dimer

Abstract Background: Increased thrombin generation is associated with an increased risk of recurrent venous thromboembolism. We investigated the relation between endogenous thrombin potential (ETP) and risk of recurrent venous thromboembolism and evaluated whether prediction of recurrence can be improved by a combined analysis of ETP and D-dimer. Methods: We followed 861 patients with first spontaneous venous thromboembolism and determined ETP and D-dimer after discontinuation of anticoagulation. Patients with natural inhibitor deficiency, lupus anticoagulant, or cancer were excluded. The study endpoint was symptomatic recurrent venous thromboembolism. Results: One hundred thirty patients (15.1%) had recurrence. High ETP (≥100%) conferred a 1.6-fold increased risk of recurrence (95% CI 1.1–2.3) after adjustment for age, sex, factor V Leiden, factor II G20210A, and duration of anticoagulation. After adjustment for D-dimer, risk of recurrence remained significantly higher among patients with high ETP [hazard ratio 1.6 (95% CI 1.01–2.4)]. After adjustment for ETP, high D-dimer (≥0.5 mg/L) conferred a 1.8-fold (95% CI 1.1–2.8) increased risk of recurrence. Compared with patients with low ETP and low D-dimer, risk of recurrence was 2.8-fold (95% CI 1.5–5.3) higher among patients with both high ETP and high D-dimer after adjustment for potential confounders. Conclusions: ETP and D-dimer are independent predictors of recurrent venous thromboembolism. Assessing risk of recurrence can be optimized by combining these indicators of thrombin generation.

scholarly journals D-Dimer Levels and Risk of Recurrent Venous Thromboembolism

JAMA ◽  
2003 ◽  
Vol 290 (8) ◽  
pp. 1071 ◽  
Author(s):  
Sabine Eichinger
Keyword(s):  
Venous Thromboembolism ◽  
Recurrent Venous Thromboembolism ◽  
D Dimer

scholarly journals D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism

2006 ◽  
Vol 4 (6) ◽  
pp. 1208-1214 ◽  
Author(s):  
S. SHRIVASTAVA ◽  
P. M. RIDKER ◽  
R. J. GLYNN ◽  
S. Z. GOLDHABER ◽  
S. MOLL ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Factor Viii ◽  
Low Intensity ◽  
Coagulant Activity ◽  
Recurrent Venous Thromboembolism ◽  
D Dimer

D-DIMER TESTING AND RECURRENT VENOUS THROMBOEMBOLISM AFTER UNPROVOKED PULMONARY EMBOLISM

2007 ◽  
Vol 5 ◽  
pp. P-T-541-P-T-541
Author(s):  
V. Pengo ◽  
B. Cosmi ◽  
C. Legnani ◽  
F. Marzot ◽  
A. Tosetto ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Recurrent Venous Thromboembolism ◽  
D Dimer
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