Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies

Cédric Logé; Alexandra Testard; Valérie Thiéry; Olivier Lozach; Mélina Blairvacq; Jean-Michel Robert; Laurent Meijer; Thierry Besson

doi:10.1016/j.ejmech.2007.09.020

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2007.09.020 ◽

2008 ◽

Vol 43 (7) ◽

pp. 1469-1477 ◽

Cited By ~ 43

Author(s):

Cédric Logé ◽

Alexandra Testard ◽

Valérie Thiéry ◽

Olivier Lozach ◽

Mélina Blairvacq ◽

...

Keyword(s):

Molecular Modeling ◽

Glycogen Synthase ◽

Biological Evaluation ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3 ◽

Cyclin Dependent Kinase ◽

Modeling Studies ◽

Molecular Modeling Studies

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ChemInform Abstract: Novel 9-Oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile Derivatives as Dual Cyclin-Dependent Kinase 1 (CDK1)/Glycogen Synthase Kinase-3 (GSK-3) Inhibitors: Synthesis, Biological Evaluation and Molecular Modeling Studies.

ChemInform ◽

10.1002/chin.200849158 ◽

2008 ◽

Vol 39 (49) ◽

Author(s):

Cedric Loge ◽

Alexandra Testard ◽

Valerie Thiery ◽

Olivier Lozach ◽

Melina Blairvacq ◽

...

Keyword(s):

Molecular Modeling ◽

Glycogen Synthase ◽

Biological Evaluation ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3 ◽

Cyclin Dependent Kinase ◽

Modeling Studies ◽

Molecular Modeling Studies

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Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: Synthesis, biological evaluation, and molecular modeling studies

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.05.044 ◽

2013 ◽

Vol 21 (15) ◽

pp. 4575-4580 ◽

Cited By ~ 12

Author(s):

Maria Rosa Buemi ◽

Laura De Luca ◽

Alba Chimirri ◽

Stefania Ferro ◽

Rosaria Gitto ◽

...

Keyword(s):

Molecular Modeling ◽

Neurodegenerative Diseases ◽

Biological Evaluation ◽

Indole Derivatives ◽

Modeling Studies ◽

Molecular Modeling Studies

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Molecular modeling studies, synthesis and biological evaluation of dabigatran analogues as thrombin inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.11.025 ◽

2016 ◽

Vol 24 (2) ◽

pp. 73-84 ◽

Cited By ~ 8

Author(s):

Ming-Hui Dong ◽

Hai-Feng Chen ◽

Yu-Jie Ren ◽

Fang-Ming Shao

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Thrombin Inhibitors ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Synthesis And Biological Evaluation

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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.12.063 ◽

2019 ◽

Vol 168 ◽

pp. 58-77 ◽

Cited By ~ 14

Author(s):

Killian Oukoloff ◽

Nicolas Coquelle ◽

Manuela Bartolini ◽

Marina Naldi ◽

Rémy Le Guevel ◽

...

Keyword(s):

Glycogen Synthase ◽

Biological Evaluation ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3 ◽

X Ray ◽

X Ray Crystallography ◽

Multifunctional Ligands

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Differential Cellular Phosphorylation of Neurofilament Heavy Side-Arms by Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinase-5

Journal of Neurochemistry ◽

10.1046/j.1471-4159.1996.66041698.x ◽

2002 ◽

Vol 66 (4) ◽

pp. 1698-1706 ◽

Cited By ~ 82

Author(s):

Sonia Guidato ◽

Li-Huei Tsai ◽

Jim Woodgett ◽

Christopher C. J. Miller

Keyword(s):

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3 ◽

Cyclin Dependent Kinase ◽

Cyclin Dependent Kinase 5

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Molecular modeling studies, synthesis, and biological evaluation of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitors

Molecular Diversity ◽

10.1007/s11030-009-9141-0 ◽

2009 ◽

Vol 13 (4) ◽

pp. 501-517 ◽

Cited By ~ 13

Author(s):

Varun A. Morde ◽

Mushtaque S. Shaikh ◽

Raghuvir R. S. Pissurlenkar ◽

Evans C. Coutinho

Keyword(s):

Plasmodium Falciparum ◽

Molecular Modeling ◽

Acyl Carrier Protein ◽

Biological Evaluation ◽

Carrier Protein ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Synthesis And Biological Evaluation

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Discovery of Selective, Substrate-Competitive, and Passive Membrane Permeable Glycogen Synthase Kinase-3β Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling of New C-Glycosylflavones

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.8b00010 ◽

2018 ◽

Vol 9 (5) ◽

pp. 1166-1183 ◽

Cited By ~ 15

Author(s):

Zhibin Liang ◽

Qing X. Li

Keyword(s):

Molecular Modeling ◽

Glycogen Synthase ◽

Biological Evaluation ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β ◽

Passive Membrane

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Biological Evaluation, Chelation, and Molecular Modeling Studies of Novel Metal-Chelating Inhibitors of NF-κB-DNA Binding: Structure Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm050617x ◽

2006 ◽

Vol 49 (12) ◽

pp. 3595-3601 ◽

Cited By ~ 12

Author(s):

Rakesh K. Sharma ◽

Shilpa Chopra ◽

Som D. Sharma ◽

Vineet Pande ◽

Maria J. Ramos ◽

...

Keyword(s):

Molecular Modeling ◽

Dna Binding ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Metal Chelating ◽

Structure Activity ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Binding Structure

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Synthesis, Biological Evaluation and Molecular Modeling Studies of New 2,3-Diheteroaryl Thiazolidin-4-Ones as NNRTIs

Chemical Biology & Drug Design ◽

10.1111/cbdd.12591 ◽

2015 ◽

Vol 86 (5) ◽

pp. 1285-1291 ◽

Cited By ~ 6

Author(s):

Utsab Debnath ◽

Saroj Verma ◽

Pankaj Singh ◽

Kavita Rawat ◽

Satish K. Gupta ◽

...

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Modeling Studies ◽

Molecular Modeling Studies

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Design, synthesis, biological evaluation and molecular modeling studies of 1-aryl-6-(3,4,5-trimethoxyphenyl)-3( Z )-hexen-1,5-diynes as a new class of potent antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.01.011 ◽

2013 ◽

Vol 62 ◽

pp. 526-533 ◽

Cited By ~ 2

Author(s):

Yu-Hsiang Lo ◽

Ying-Ting Lin ◽

Yu-Peng Liu ◽

Tsai-Hui Duh ◽

Pei-Jung Lu ◽

...

Keyword(s):

Molecular Modeling ◽

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

New Class ◽

Modeling Studies ◽

Molecular Modeling Studies

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