Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

2014 ◽  
Vol 75 ◽  
pp. 82-95 ◽  
Author(s):  
Oscar M. Bautista-Aguilera ◽  
Gerard Esteban ◽  
Irene Bolea ◽  
Katarina Nikolic ◽  
Danica Agbaba ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Modeling ◽  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitors ◽  
Potential Treatment ◽  
Design Synthesis ◽  
Qsar Analysis ◽  
Pharmacological Evaluation

scholarly journals Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

2020 ◽  
Vol 11 (2) ◽  
pp. 225-233 ◽  
Author(s):  
Xiao-Bing Wang ◽  
Fu-Cheng Yin ◽  
Ming Huang ◽  
Neng Jiang ◽  
Jin-Shuai Lan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Monoamine Oxidase ◽  
Pc12 Cells ◽  
Blood Brain Barrier ◽  
Monoamine Oxidase Inhibitors ◽  
Brain Barrier ◽  
Potential Treatment ◽  
Blood Brain ◽  
Low Toxicity

Good permeability to cross the blood–brain barrier; low toxicity to PC12 cells.

Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer’s disease

2016 ◽  
Vol 109 ◽  
pp. 376-385 ◽  
Author(s):  
Wei Liu ◽  
Ming Lang ◽  
Moussa B.H. Youdim ◽  
Tamar Amit ◽  
Yewei Sun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinesterase Inhibitors ◽  
Potential Treatment ◽  
Design Synthesis

Design, Synthesis, and Molecular-modeling Study of Aminothienopyridine Analogues of Tacrine for Alzheimer's Disease

2010 ◽  
Vol 343 (10) ◽  
pp. 590-601 ◽  
Author(s):  
Mohga M. Badran ◽  
Maha Abdel Hakeem ◽  
Suzan M. Abuel-Maaty ◽  
Afaf El-Malah ◽  
Rania M. Abdel Salam
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Modeling ◽  
Design Synthesis ◽  
Molecular Modeling Study ◽  
Modeling Study
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