2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.04.002 ◽

2018 ◽

Vol 151 ◽

pp. 363-375 ◽

Cited By ~ 16

Author(s):

Niccolò Chiaramonte ◽

Silvia Bua ◽

Marta Ferraroni ◽

Alessio Nocentini ◽

Alessandro Bonardi ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Enzyme Inhibition ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Pressure Lowering ◽

Human Carbonic Anhydrase

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Carbonic anhydrase inhibitors – part 70. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering agents derived from nicotinic acid and aromatic/heterocyclic sulfonamides

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(99)00212-3 ◽

1999 ◽

Vol 34 (10) ◽

pp. 799-808 ◽

Cited By ~ 9

Author(s):

C Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Nicotinic Acid ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Pressure Lowering ◽

Aromatic Heterocyclic ◽

Ocular Pharmacology

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ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 52. Metal Complexes of Heterocyclic Sulfonamides: A New Class of Strong Topical Intraocular Pressure-Lowering Agents in Rabbits.

ChemInform ◽

10.1002/chin.199837153 ◽

2010 ◽

Vol 29 (37) ◽

pp. no-no

Author(s):

C. T. SUPURAN ◽

F. MINCIONE ◽

A. SCOZZAFAVA ◽

F. BRIGANTI ◽

G. MINCIONE ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Metal Complexes ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Pressure Lowering

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ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 70. Synthesis and Ocular Pharmacology of a New Class of Water-Soluble, Topically Effective Intraocular Pressure Lowering Agents Derived from Nicotinic Acid and Aromatic/Heterocyclic Sulfonamides

ChemInform ◽

10.1002/chin.200006134 ◽

2010 ◽

Vol 31 (6) ◽

pp. no-no

Author(s):

Claudiu T. Supuran ◽

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Nicotinic Acid ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Pressure Lowering ◽

Aromatic Heterocyclic ◽

Ocular Pharmacology

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Carbonic anhydrase inhibitors — Part 52. Metal complexes of heterocyclic sulfonamides: A new class of strong topical intraocular pressure-lowering agents in rabbits

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(98)80059-7 ◽

1998 ◽

Vol 33 (4) ◽

pp. 247-254 ◽

Cited By ~ 103

Author(s):

Claudiu T. Supuran ◽

Francesco Mincione ◽

Andrea Scozzafava ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Metal Complexes ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Pressure Lowering

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Comparison of Intraocular Pressure Lowering by Topical and Systemic Carbonic Anhydrase Inhibitors in the Rabbit

Journal of Ocular Pharmacology and Therapeutics ◽

10.1089/jop.1999.15.51 ◽

1999 ◽

Vol 15 (1) ◽

pp. 51-57 ◽

Cited By ~ 8

Author(s):

MAHER M. FANOUS ◽

PRATAP CHALLA ◽

THOMAS H. MAREN

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

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Carbonic anhydrase inhibitors – Part 78. Synthesis of water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(00)00130-6 ◽

2000 ◽

Vol 35 (3) ◽

pp. 309-321 ◽

Cited By ~ 9

Author(s):

C Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

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Discovery of Strecker-type α-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.3109/14756366.2016.1156676 ◽

2016 ◽

Vol 31 (6) ◽

pp. 1707-1711 ◽

Cited By ~ 4

Author(s):

Mikhail Krasavin ◽

Roman Stavniichuk ◽

Sergey Zozulya ◽

Petro Borysko ◽

Daniela Vullo ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Differential Scanning Fluorimetry ◽

Human Carbonic Anhydrase

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Carbonic anhydrase inhibitors. Part 60##See ref. [1]. The topical intraocular pressure-lowering properties of metal complexes of a heterocyclic sulfonamide: influence of the metal ion upon biological activity

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(00)80028-8 ◽

1999 ◽

Vol 34 (7-8) ◽

pp. 585-595 ◽

Cited By ~ 3

Author(s):

Claudiu T. Supuran ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Luca Menabuoni ◽

Fabrizio Briganti ◽

...

Keyword(s):

Biological Activity ◽

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Metal Complexes ◽

Metal Ion ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

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4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki–Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b01771 ◽

2016 ◽

Vol 59 (2) ◽

pp. 721-732 ◽

Cited By ~ 21

Author(s):

Benedetta Cornelio ◽

Marie Laronze-Cochard ◽

Mariangela Ceruso ◽

Marta Ferraroni ◽

Graham A. Rance ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Enzyme Inhibition ◽

Carbonic Anhydrase Inhibitors ◽

X Ray ◽

Human Carbonic Anhydrase

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Carbonic anhydrase inhibitors: Design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.06.054 ◽

2005 ◽

Vol 15 (17) ◽

pp. 3821-3827 ◽

Cited By ~ 16

Author(s):

Francesco Mincione ◽

Michele Starnotti ◽

Emanuela Masini ◽

Lucia Bacciottini ◽

Chiara Scrivanti ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Rabbit Model ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering ◽

Lowering Activity

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