Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance

2021 ◽  
pp. 113930
Author(s):  
Bao Cheng ◽  
Guirong Zhu ◽  
Linghua Meng ◽  
Guolin Wu ◽  
Qin Chen ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Binding Site ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site

scholarly journals Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures

2017 ◽  
Vol 9 (15) ◽  
pp. 1765-1794 ◽  
Author(s):  
Wenlong Li ◽  
Honghao Sun ◽  
Shengtao Xu ◽  
Zheying Zhu ◽  
Jinyi Xu
Keyword(s):  
Binding Site ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site ◽  
Privileged Structures

scholarly journals Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site

Molecules ◽  
2016 ◽  
Vol 21 (10) ◽  
pp. 1375 ◽  
Author(s):  
Mengqi Dong ◽  
Fang Liu ◽  
Hongyu Zhou ◽  
Shumei Zhai ◽  
Bing Yan
Keyword(s):  
Binding Site ◽  
Natural Product ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site ◽  
Privileged Scaffold

scholarly journals Abstract 4608: Colchicine binding site agents as potent tubulin inhibitors suppressing triple negative breast cancer

2019 ◽  
Author(s):  
Shanshan Deng ◽  
Hao Chen ◽  
Raisa Krutilina ◽  
Najah G. Albadari ◽  
Tiffany N. Seagroves ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Binding Site ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site

scholarly journals Abstract 4608: Colchicine binding site agents as potent tubulin inhibitors suppressing triple negative breast cancer

2019 ◽  
Author(s):  
Shanshan Deng ◽  
Hao Chen ◽  
Raisa Krutilina ◽  
Najah G. Albadari ◽  
Tiffany N. Seagroves ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Binding Site ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site

scholarly journals An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site

2012 ◽  
Vol 29 (11) ◽  
pp. 2943-2971 ◽  
Author(s):  
Yan Lu ◽  
Jianjun Chen ◽  
Min Xiao ◽  
Wei Li ◽  
Duane D. Miller
Keyword(s):  
Binding Site ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site

Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin

2021 ◽  
Author(s):  
Kewei Sun ◽  
Zhonghao Sun ◽  
Fenglan Zhao ◽  
Guangzhi Shan ◽  
Qingguo Meng
Keyword(s):  
Multidrug Resistance ◽  
Binding Site ◽  
Crystal Structures ◽  
Computer Simulations ◽  
Structural Studies ◽  
Targeted Agents ◽  
Lead Compounds ◽  
Cancer Chemotherapeutics ◽  
Colchicine Binding Site ◽  
P Glycoprotein

Microtubules have been a concerning target of cancer chemotherapeutics for decades, and several tubulin-targeted agents, such as paclitaxel, vincristine and vinorelbine, have been approved. The colchicine binding site is one of the primary targets on microtubules and possesses advantages compared with other tubulin-targeted agents, such as inhibitors of tumor vessels and overcoming P-glycoprotein overexpression-mediated multidrug resistance. This study reviews and summarizes colchicine binding site inhibitors reported in recent years with structural studies via the crystal structures of complexes or computer simulations to discover new lead compounds. We are attempting to resolve the challenge of colchicine site agent research.

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