scholarly journals Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats

2014 ◽  
Vol 741 ◽  
pp. 132-139 ◽  
Author(s):  
Dennis A. Burke ◽  
Pooneh Heshmati ◽  
Ehsan Kholdebarin ◽  
Edward D. Levin
Keyword(s):  
Spatial Learning ◽  
Nicotinic Receptor ◽  
Receptor Activity ◽  
Glutamate Antagonist ◽  
Learning Impairment

Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice

2013 ◽  
Vol 12 (4) ◽  
pp. 414-423 ◽  
Author(s):  
E. Azzopardi ◽  
M. Typlt ◽  
B. Jenkins ◽  
S. Schmid
Keyword(s):  
Spatial Learning ◽  
Knockout Mice ◽  
Nicotinic Receptor ◽  
Sensorimotor Gating

scholarly journals The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications

2001 ◽  
Vol 21 (19) ◽  
pp. 7463-7473 ◽  
Author(s):  
Corey Hilmas ◽  
Edna F. R. Pereira ◽  
Manickavasagom Alkondon ◽  
Arash Rassoulpour ◽  
Robert Schwarcz ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Kynurenic Acid ◽  
Receptor Expression ◽  
Receptor Activity ◽  
Brain Metabolite ◽  
The Brain

Modulation of Nicotinic Receptor Activity in the Central Nervous System

2001 ◽  
Vol 15 ◽  
pp. S19-S25 ◽  
Author(s):  
E. X. Albuquerque ◽  
M. D. Santos ◽  
M. Alkondon ◽  
E. F. R. Pereira ◽  
A. Maelicke
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nicotinic Receptor ◽  
Receptor Activity ◽  
The Central Nervous System

scholarly journals Molecular Indices of Neuronal and Glial Plasticity in the Hippocampal Formation in a Rodent Model of Age-Induced Spatial Learning Impairment

1996 ◽  
Vol 16 (10) ◽  
pp. 3427-3443 ◽  
Author(s):  
Kiminobu Sugaya ◽  
Michael Chouinard ◽  
Rhonda Greene ◽  
Michael Robbins ◽  
David Personett ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Hippocampal Formation ◽  
Rodent Model ◽  
Learning Impairment

scholarly journals Role of Donepezil in Autism: Its Conduciveness in Psychopharmacotherapy

2011 ◽  
Vol 2011 ◽  
pp. 1-2 ◽  
Author(s):  
Rohit Kant Srivastava ◽  
Medhavi Agarwal ◽  
Ashish Pundhir
Keyword(s):  
Case Report ◽  
Autistic Child ◽  
Nicotinic Receptor ◽  
Marked Improvement ◽  
Subsequent Treatment ◽  
Receptor Activity ◽  
Behavioural Symptoms ◽  
Autistic Symptoms ◽  
Patient Department

A woman consulted psychiatric Out-Patient Department (OPD) for her 5-year and 2-month-old son presenting with typical autistic symptoms like social, behavioural, and communicational ineptitudeness. Subsequent treatment with Donepezil resulted in marked improvement in the aforementioned symptomatology. Recent studies in autistic child have shown diminished acetylcholine and nicotinic receptor activity, thus an acetylcholinergic enhancer, Donepezil, likely accounts for improvement in autistic symptoms. Evidently, the case report consolidates Donepezil role as a potentially useful agent in the treatment of cognitive and behavioural symptoms observed in this disorder.

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