The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride does not improve joint damage in an experimental model of knee osteoarthritis in rabbits

2017 ◽  
Vol 794 ◽  
pp. 8-14 ◽  
Author(s):  
Jorge A. Roman-Blas ◽  
Aránzazu Mediero ◽  
Lidia Tardío ◽  
Sergio Portal-Nuñez ◽  
Paula Gratal ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Chondroitin Sulfate ◽  
Experimental Model ◽  
Combined Therapy ◽  
Joint Damage ◽  
Glucosamine Sulfate ◽  
Glucosamine Hydrochloride

scholarly journals Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis

2019 ◽  
Vol 10 ◽  
pp. 204062231987001 ◽  
Author(s):  
Francisco J. Blanco ◽  
María Camacho-Encina ◽  
Lucía González-Rodríguez ◽  
Ignacio Rego-Pérez ◽  
Jesús Mateos ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Chondroitin Sulfate ◽  
Therapeutic Response ◽  
Prediction Models ◽  
Predictive Biomarkers ◽  
Proteomics Data ◽  
Operating Characteristics ◽  
Gh Treatment ◽  
Blind Test ◽  
Glucosamine Hydrochloride

Background: In the present study, we explored potential protein biomarkers useful to predict the therapeutic response of knee osteoarthritis (KOA) patients treated with pharmaceutical grade Chondroitin sulfate/Glucosamine hydrochloride (CS+GH; Droglican, Bioiberica), in order to optimize therapeutic outcomes. Methods: A shotgun proteomic analysis by iTRAQ labelling and liquid chromatography–mass spectrometry (LC-MS/MS) was performed using sera from 40 patients enrolled in the Multicentre Osteoarthritis interVEntion trial with Sysadoa (MOVES). The panel of proteins potentially useful to predict KOA patient’s response was clinically validated in the whole MOVES cohort at baseline ( n = 506) using commercially available enzyme-linked immunosorbent assays kits. Logistic regression models and receiver-operating-characteristics (ROC) curves were used to analyze the contribution of these proteins to our prediction models of symptomatic drug response in KOA. Results: In the discovery phase of the study, a panel of six putative predictive biomarkers of response to CS+GH (APOA2, APOA4, APOH, ITIH1, C4BPa and ORM2) were identified by shotgun proteomics. Data are available via ProteomeXchange with identifier PXD012444. In the verification phase, the panel was verified in a larger set of KOA patients ( n = 262). Finally, ITIH1 and ORM2 were qualified by a blind test in the whole MOVES cohort at baseline. The combination of these biomarkers with clinical variables predict the patients’ response to CS+GH with a specificity of 79.5% and a sensitivity of 77.1%. Conclusions: Combining clinical and analytical parameters, we identified one biomarker that could accurately predict KOA patients’ response to CS+GH treatment. Its use would allow an increase in response rates and safety for the patients suffering KOA.

scholarly journals Effect of systemic enzyme therapy on clinical manifestations of inflammation in gonarthrosis

2018 ◽  
Vol 10 (2) ◽  
pp. 107-112
Author(s):  
V I Mazurov ◽  
A G Dorovskikh ◽  
E A Trofimov
Keyword(s):  
Chondroitin Sulfate ◽  
Soft Tissues ◽  
Combined Therapy ◽  
Clinical Manifestations ◽  
Glucosamine Sulfate ◽  
Knee Joints ◽  
Control Group ◽  
Osteoarthritis Of The Knee ◽  
Enzyme Therapy ◽  
Choice Of Treatment

Despite a significant number of studies on various schemes of OA therapy, there are only some studies with the use of systemic enzyme therapy (ETS) in combination with NSAIDs and / or SYSADOA. The aim was to study the effect of different groups of drugs (NSAIDs, ETS, SYSADOA) on the clinical course of gonarthrosis, as well as to develop an algorithm for the choice of treatment tactics depending on the clinical and sonographic manifestations of this disease. Methods. The data of 46 patients with stage I and stage II OA of Kellgren-Lawrence were analyzed. Patients of the first group received combined oral therapy with chondroitin sulfate (HS) 500 mg 2 times a day and glucosamine sulfate (GS) 750 mg 2 times a day in combination with selective NSAIDs. The second group of patients received combined therapy of HS 500 mg 2 times a day with the GS 750 mg 2 times daily together with Phlogenzym (PL), 2 tablets 3 times a day. All patients included in the study were examined initially, after 8 and 12 weeks. Procedures included clinical (VAS, WOMAC) and instrumental methods with the use of ultrasound of joints to evaluate the pathology of soft tissues and detect synovitis.. Results. Comparing groups 1 (HS, GS and NSAIDs) and 2 (HS and GS together with PL) on the effect on the structural state of cartilage and the dynamics of the main ultrasonic manifestations of OA knee joint, it should be noted that the effectiveness of drugs HS and GS in combination with enzyme therapy was higher, because in this group of treatment of synovitis decreased, whereas in the group of HS and GS, together with NSAIDs, these parameters either increased or remained unchanged. Conclusions. The use of polyenzyme drugs significantly increases the effectiveness of complex therapy in patients with osteoarthritis of the knee joints. In patients with gonarthrosis treated with a combination of chondroitin sulfate, glucosamine sulfate and phlogenzym was observed a significant reduction in the severity of synovitis, as well as more frequent lower daily dose of the selective NSAID or their full cancellation, compared with a control group of patients treated with symptomatic drugs retardation in combination with NSAIDs. (For citation: Mazurov VI, Dorovskikh AG, Trofimov EA. Effect of systemic enzyme therapy on clinical manifestations of inflammation in gonarthrosis. Herald of North-Western State Medical University named after I.I. Mechnikov. 2018;10(2):107-112).

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