Imaging the impact of cyclosporin A and dipyridamole on P-glycoprotein (ABCB1) function at the blood-brain barrier: A [11C]-N-desmethyl-loperamide PET study in nonhuman primates

2016 ◽  
Vol 91 ◽  
pp. 98-104 ◽  
Author(s):  
Annelaure Damont ◽  
Sébastien Goutal ◽  
Sylvain Auvity ◽  
Héric Valette ◽  
Bertrand Kuhnast ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Blood Brain Barrier ◽  
Nonhuman Primates ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
The Impact

scholarly journals P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of 11C-Metoclopramide Across the Blood–Brain Barrier: A PET Study on Nonhuman Primates

2018 ◽  
Vol 59 (10) ◽  
pp. 1609-1615 ◽  
Author(s):  
Sylvain Auvity ◽  
Fabien Caillé ◽  
Solène Marie ◽  
Catriona Wimberley ◽  
Martin Bauer ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Nonhuman Primates ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain

The impact of depressive disorders and treatment with an antidepressant on the activity of P-glycoprotein at the blood-brain barrier

2010 ◽  
Vol 122 ◽  
pp. S39-S40
Author(s):  
O.L. de Klerk⁎ ◽  
A.T.M. Willemsen ◽  
F.J. Bosker ◽  
P. Meerlo ◽  
R.A. Dierckx ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Depressive Disorders ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
The Impact

Quantitative Investigation of the Impact of P-Glycoprotein Inhibition on Drug Transport across Blood-Brain Barrier in Rats

2010 ◽  
Vol 39 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Hiroshi Sugimoto ◽  
Hideki Hirabayashi ◽  
Yoshiaki Kimura ◽  
Atsutoshi Furuta ◽  
Nobuyuki Amano ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Drug Transport ◽  
Brain Barrier ◽  
Quantitative Investigation ◽  
P Glycoprotein ◽  
Blood Brain ◽  
The Impact ◽  
Glycoprotein Inhibition

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein

1993 ◽  
Vol 46 (6) ◽  
pp. 1096-1099 ◽  
Author(s):  
Akira Tsuji ◽  
Ikumi Tamai ◽  
Atsushi Sakata ◽  
Yoshiyuki Tenda ◽  
Tetsuya Terasaki
Keyword(s):  
Cyclosporin A ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Multidrug Transporter ◽  
P Glycoprotein ◽  
Blood Brain

In Vivo Evaluation of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman Primates Using [11C]Verapamil

2005 ◽  
Vol 316 (2) ◽  
pp. 647-653 ◽  
Author(s):  
Young-Joo Lee ◽  
Jun Maeda ◽  
Hiroyuki Kusuhara ◽  
Takashi Okauchi ◽  
Motoki Inaji ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Nonhuman Primates ◽  
Brain Barrier ◽  
In Vivo Evaluation ◽  
P Glycoprotein ◽  
Blood Brain

scholarly journals Assessing the Impact of Lithium Chloride on the Expression of P-Glycoprotein at the Blood-Brain Barrier

2017 ◽  
Vol 106 (9) ◽  
pp. 2625-2631 ◽  
Author(s):  
Stephanie A. Newman ◽  
Yijun Pan ◽  
Jennifer L. Short ◽  
Joseph A. Nicolazzo
Keyword(s):  
Blood Brain Barrier ◽  
Lithium Chloride ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
The Impact

scholarly journals In VitroandIn VivoEvidence for Amphotericin B as a P-Glycoprotein Substrate on the Blood-Brain Barrier

2014 ◽  
Vol 58 (8) ◽  
pp. 4464-4469 ◽  
Author(s):  
Ji-Qin Wu ◽  
Kun Shao ◽  
Xuan Wang ◽  
Rui-Ying Wang ◽  
Ya-Hui Cao ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Blood Brain Barrier ◽  
Fungal Infections ◽  
Brain Barrier ◽  
Content Type ◽  
P Glycoprotein ◽  
Blood Brain ◽  
The Impact ◽  
The Brain

ABSTRACTAmphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing the blood-brain barrier (BBB). The uptake of AMB by primary brain capillary endothelial cellsin vitrowas significantly enhanced after inhibition of P-gp by verapamil. The impact of two model P-gp inhibitors, verapamil and itraconazole, on brain/plasma ratios of AMB was examined in both uninfected CD-1 mice and those intracerebrally infected withCryptococcus neoformans. In uninfected mice, the brain/plasma ratios of AMB were increased 15 min (3.5 versus 2.0;P< 0.05) and 30 min (5.2 versus 2.8;P< 0.05) after administration of verapamil or 45 min (6.0 versus 3.9;P< 0.05) and 60 min (5.4 versus 3.8;P< 0.05) after itraconazole administration. The increases in brain/plasma ratios were also observed in infected mice treated with AMB and P-gp inhibitors. The brain tissue fungal CFU in infected mice were significantly lower in AMB-plus-itraconazole or verapamil groups than in the untreated group (P< 0.005), but none of the treatments protected the mice from succumbing to the infection. In conclusion, we demonstrated that P-gp inhibitors can enhance the uptake of AMB through the BBB, suggesting that AMB is a P-gp substrate.

In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier

1994 ◽  
Vol 48 (10) ◽  
pp. 1989-1992 ◽  
Author(s):  
Atsushi Sakata ◽  
Ikumi Tamai ◽  
Kouichi Kawazu ◽  
Yoshiharu Deguchi ◽  
Toshimasa Ohnishi ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain
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