Suspicious ultrasound characteristics correlate with multiple factors that predict central lymph node metastasis of papillary thyroid carcinoma: Significant role of HBME-1

2020 ◽  
Vol 123 ◽  
pp. 108801 ◽  
Author(s):  
Li Jianming ◽  
Liu Jibin ◽  
Qian Linxue
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid ◽  
Central Lymph Node Metastasis ◽  
Central Lymph Node ◽  
Node Metastasis ◽  
Multiple Factors ◽  
Central Lymph

scholarly journals A Nomogram Based on Clinical and Ultrasound Characteristics to Predict Central Lymph Node Metastasis of Papillary Thyroid Carcinoma

2021 ◽  
Vol 12 ◽  
Author(s):  
Jia-Wei Feng ◽  
Li-Zhao Hong ◽  
Fei Wang ◽  
Wan-Xiao Wu ◽  
Jun Hu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Central Lymph Node Metastasis ◽  
Central Lymph Node ◽  
Node Metastasis ◽  
The Status ◽  
Central Lymph

BackgroundThe status of lymph nodes in the central compartment is crucial to determining the surgical strategies for papillary thyroid carcinoma (PTC). We aimed to develop a nomogram for predicting central lymph node metastasis (CLNM).MethodsA total of 886 PTC patients who underwent total thyroidectomy or lobectomy with central neck dissection (CND) from July 2019 to June 2020 were retrospectively retrieved. Clinical and ultrasound features were collected. Univariate and multivariate analysis were performed to determine risk factors of CLNM. A nomogram for predicting CLNM was developed, internal and external calibration was performed for the established model.ResultsVariables (sex, chronic lymphocytic thyroiditis, tumor size, the number of foci, tumor location, margin) significantly associated with CLNM were included in the nomogram. The nomogram showed excellent calibration in the training group and validation group, with area under curves of 0.806 (95% CI, 0.771 to 0.825), and 0.799 (95% CI, 0.778–0.813) respectively.ConclusionThrough this accurate and easy-to-use nomogram, the possibility of CLNM can be objectively quantified preoperatively. Clinicians can use this nomogram to evaluate the status of lymph nodes in PTC patients and consider prophylactic CND for those with high scores.

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