Techniques for the placement of hepatic artery catheters for regional chemotherapy in unresectable liver metastases

2007 ◽  
Vol 33 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Y. Van Nieuwenhove ◽  
M. Aerts ◽  
B. Neyns ◽  
G. Delvaux
Keyword(s):  
Liver Metastases ◽  
Hepatic Artery ◽  
Regional Chemotherapy ◽  
Unresectable Liver Metastases

scholarly journals Repeated Hepatic Dearterialization for Unresectable Liver Metastases From Gastric Cancer: Review of Five Cases

HPB Surgery ◽  
1995 ◽  
Vol 8 (3) ◽  
pp. 175-180 ◽  
Author(s):  
Takeo Kimoto ◽  
Naofumi Nagasue ◽  
Hitoshi Kohno ◽  
Yu-Chung Chang ◽  
Hiroyuki Taniura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Liver Metastases ◽  
Hepatic Artery ◽  
Tumour Regression ◽  
Long Survival ◽  
Artery Cannulation ◽  
Cancer Review ◽  
Hepatic Dearterialization ◽  
Multiple Metastases ◽  
Unresectable Liver Metastases

A novel method of repeated hepatic dearterialization was evaluated in five patients with multiple metastases from gastric cancer in both hepatic lobes. After gastrectomy with extensive lymph node dissection (R2/3), all patients underwent implantation of a vascular occluder around the hepatic artery. Cannulation of the hepatic artery was added for later chemotherapy. The hepatic artery was occluded repeatedly for 1 hour twice daily in combination with intrahepatic infusion of anticancer drugs for as long as possible. Three of five patients demonstrated marked tumour regression with unexpectedly long survival (16 months in two patients and one still alive at 15 months). Carcinoembryonic antigen (CEA) levels decreased to almost normal in four patients who had initially high levels. The present experiences seems to indicate that long survival can be hoped for in patients with advanced gastric cancer with unresectable liver metastases.

Conversion to complete surgical treatment using hepatic artery infusional chemotherapy in patients with unresectable liver metastases from colorectal cancer.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 472-472
Author(s):  
John Brian Ammori ◽  
Nancy E. Kemeny ◽  
Andrea Cercek ◽  
Ronald P. DeMatteo ◽  
Peter J Allen ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Hepatic Artery ◽  
Risk Score ◽  
Systemic Chemotherapy ◽  
Clinical Risk Score ◽  
Clinical Risk ◽  
Pump Placement ◽  
Unresectable Liver Metastases ◽  
Previously Treated

472 Background: Hepatic artery infusional (HAI) chemotherapy effectively treats colorectal liver metastases (CRLM). This study analyzes the combination of HAI and systemic chemotherapy for treating unresectable CRLM, focusing on the conversion to complete resection and/or ablation (R/A) and long term outcomes. Methods: All patients with initially unresectable CRLM treated with HAI and systemic chemotherapy from 2000-2009 were included. Patients who responded sufficiently to undergo complete R/A were compared to those who did not convert. Results: 373 patients were included. 296 (79 %) were previously treated and 77 (21 %) were chemo naïve. 115 (31 %) were on protocol and 258 (69 %) were not on protocol. 93 patients (25%) subsequently underwent complete R/A (conversion group). Of the 115 protocol patients, 47 (41 %) underwent complete R/A. The percentage of patients submitted to complete R/A increased from 16% during 2000-2003 to 30% during 2004-2009. 43% of patients who were chemotherapy-naïve prior to HAI therapy eventually underwent complete R/A, compared to 15% who were initially treated with systemic therapy (p<0.001). Factors associated with conversion on multivariate analysis were more recent treatment (2004-2009), no prior chemotherapy, and a clinical risk score < 3. Overall survival was greater in the conversion group, with a median and predicted 5-year survival from the time of HAI pump placement of 54 months and 49%, compared to 19 months and 6%, respectively (p<0.001). Conclusions: One-quarter of patients with unresectable CRLM responded sufficiently to undergo complete R/A following HAI plus systemic chemotherapy. Conversion was more likely in patients who were chemotherapy-naïve (43 %), had a clinical risk score < 3, and were treated in the more recent era. Survival in the conversion group was significantly better.

scholarly journals Prolonged continuous hepatic artery infusion with interleukin-2 in unresectable liver metastases of colorectal cancer: A phase IA—B study

1996 ◽  
Vol 7 (3) ◽  
pp. 317-319
Author(s):  
S.H. Goey ◽  
A.M.M. Eggermont ◽  
R. Oskam ◽  
Th. Wiggers ◽  
R.L.H Bolhuis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Hepatic Artery ◽  
Interleukin 2 ◽  
Hepatic Artery Infusion ◽  
Unresectable Liver Metastases
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