scholarly journals Anti-endotoxin Hyperimmune Globulin Attenuates Portal Cytokinaemia, Phagocytic Cell Priming, and Acute Lung Injury after Lower Limb Ischaemia-reperfusion Injury

2007 ◽  
Vol 33 (3) ◽  
pp. 330-339 ◽  
Author(s):  
D.W. Harkin ◽  
R. Arnold ◽  
M. Hoper
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Reperfusion Injury ◽  
Lower Limb ◽  
Limb Ischaemia ◽  
Phagocytic Cell ◽  
Ischaemia Reperfusion Injury ◽  
Lower Limb Ischaemia ◽  
Ischaemia Reperfusion ◽  
Hyperimmune Globulin

Lower limb ischaemia-reperfusion injury alters gastrointestinal structure and function

1997 ◽  
Vol 84 (10) ◽  
pp. 1425-1429 ◽  
Author(s):  
M. M. I. Yassin ◽  
A. A. B. Barros D'Sa ◽  
T. G. Parks ◽  
M. D. McCaigue ◽  
P. Leggett ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Lower Limb ◽  
Structure And Function ◽  
Limb Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Lower Limb Ischaemia ◽  
Ischaemia Reperfusion ◽  
And Function

Lower limb ischaemia-reperfusion injury alters gastrointestinal structure and function

1997 ◽  
Vol 84 (10) ◽  
pp. 1425-1429 ◽  
Author(s):  
M. M. I. Yassin ◽  
A. A. B. Barros D'Sa ◽  
T. G. Parks ◽  
M. D. McCaigue ◽  
P. Leggett ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Lower Limb ◽  
Structure And Function ◽  
Limb Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Lower Limb Ischaemia ◽  
Ischaemia Reperfusion ◽  
And Function

Ischaemic preconditioning before lower limb ischaemia-reperfusion protects against acute lung injury

2001 ◽  
Vol 88 (4) ◽  
pp. 602-602
Author(s):  
D. W. Harkin ◽  
A. A. B. Barros D'Sa ◽  
K. McCallion ◽  
R. Baker ◽  
M. Hoper ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Lower Limb ◽  
Limb Ischaemia ◽  
Ischaemic Preconditioning ◽  
Lower Limb Ischaemia ◽  
Ischaemia Reperfusion

scholarly journals Effects of experimental lower-limb ischaemia-reperfusion injury on the mesenteric microcirculation

2002 ◽  
Vol 89 (2) ◽  
pp. 185-191
Author(s):  
X. H. T. Wehrens ◽  
E. V. Rouwet ◽  
M. G. A. oude Egbrink ◽  
D. W. Slaaf ◽  
G. Ramsay
Keyword(s):  
Reperfusion Injury ◽  
Lower Limb ◽  
Limb Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Lower Limb Ischaemia ◽  
Ischaemia Reperfusion ◽  
Mesenteric Microcirculation

Effects of experimental lower-limb ischaemia–reperfusion injury on the mesenteric microcirculation

2002 ◽  
Vol 89 (2) ◽  
pp. 185-191 ◽  
Author(s):  
X. H. T Wehrens ◽  
E. V Rouwet ◽  
M. G. A oude Egbrink ◽  
D. W Slaaf ◽  
G Ramsay
Keyword(s):  
Reperfusion Injury ◽  
Lower Limb ◽  
Limb Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Lower Limb Ischaemia ◽  
Ischaemia Reperfusion ◽  
Mesenteric Microcirculation

scholarly journals Intravascular donor monocytes play a central role in lung transplant ischaemia-reperfusion injury

Thorax ◽  
2017 ◽  
Vol 73 (4) ◽  
pp. 350-360 ◽  
Author(s):  
Kate Colette Tatham ◽  
Kieran Patrick O'Dea ◽  
Rosalba Romano ◽  
Hannah Elizabeth Donaldson ◽  
Kenji Wakabayashi ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Reperfusion Injury ◽  
Lung Transplant ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Lung Dysfunction ◽  
Post Implantation

RationalePrimary graft dysfunction in lung transplant recipients derives from the initial, largely leukocyte-dependent, ischaemia-reperfusion injury. Intravascular lung-marginated monocytes have been shown to play key roles in experimental acute lung injury, but their contribution to lung ischaemia-reperfusion injury post transplantation is unknown.ObjectiveTo define the role of donor intravascular monocytes in lung transplant-related acute lung injury and primary graft dysfunction.MethodsIsolated perfused C57BL/6 murine lungs were subjected to warm ischaemia (2 hours) and reperfusion (2 hours) under normoxic conditions. Monocyte retention, activation phenotype and the effects of their depletion by intravenous clodronate-liposome treatment on lung inflammation and injury were determined. In human donor lung transplant samples, the presence and activation phenotype of monocytic cells (low side scatter, 27E10+, CD14+, HLA-DR+, CCR2+) were evaluated by flow cytometry and compared with post-implantation lung function.ResultsIn mouse lungs following ischaemia-reperfusion, substantial numbers of lung-marginated monocytes remained within the pulmonary microvasculature, with reduced L-selectin and increased CD86 expression indicating their activation. Monocyte depletion resulted in reductions in lung wet:dry ratios, bronchoalveolar lavage fluid protein, and perfusate levels of RAGE, MIP-2 and KC, while monocyte repletion resulted in a partial restoration of the injury. In human lungs, correlations were observed between pre-implantation donor monocyte numbers/their CD86 and TREM-1 expression and post-implantation lung dysfunction at 48 and 72 hours.ConclusionsThese results indicate that lung-marginated intravascular monocytes are retained as a ‘passenger’ leukocyte population during lung transplantation, and play a key role in the development of transplant-associated ischaemia-reperfusion injury.

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