The conditioning role of polarization in U.S. senate election outcomes: A direct-election era & voter-level analysis

2019 ◽  
Vol 59 ◽  
pp. 1-16 ◽  
Author(s):  
Carlos Algara
Keyword(s):  
Direct Election ◽  
Senate Election ◽  
Level Analysis

Multi-level analysis of cultural phenomena: The role of ERPs approach to prejudice

2009 ◽  
Vol 39 (1) ◽  
pp. 81-110 ◽  
Author(s):  
AGUSTÍN IBÁÑEZ ◽  
ANDRÉS HAYE ◽  
RAMIRO GONZÁLEZ ◽  
ESTEBAN HURTADO ◽  
RODRIGO HENRÍQUEZ
Keyword(s):  
Multi Level ◽  
Level Analysis

scholarly journals An autonomous, but INSIG-modulated, role for the Sterol Sensing Domain in mallostery-regulated ERAD of yeast HMG-CoA reductase

2020 ◽  
pp. jbc.RA120.015910
Author(s):  
Margaret A Wangeline ◽  
Randolph Y Hampton
Keyword(s):  
Binding Site ◽  
Quaternary Structure ◽  
Limited Proteolysis ◽  
Hmg Coa Reductase ◽  
Coa Reductase ◽  
Level Analysis

HMG-CoA reductase (HMGR) undergoes feedback-regulated degradation as part of sterol pathway control. Degradation of the yeast HMGR isozyme Hmg2 is controlled by the sterol pathway intermediate GGPP, which causes misfolding of Hmg2, leading to degradation by the HRD pathway; we call this process mallostery. We evaluated the role of the Hmg2 sterol sensing domain (SSD) in mallostery, as well as the involvement of the highly conserved INSIG proteins. We show that the Hmg2 SSD is critical for regulated degradation of Hmg2 and required for mallosteric misfolding of GGPP as studied by in vitro limited proteolysis. The Hmg2 SSD functions independently of conserved yeast INSIG proteins, but its function was modulated by INSIG, thus imposing a second layer of control on Hmg2 regulation. Mutant analyses indicated that SSD-mediated mallostery occurred prior to and independent of HRD-dependent ubiquitination. GGPP-dependent misfolding was still extant but occurred at a much slower rate in the absence of a functional SSD, indicating that the SSD facilitates a physiologically useful rate of GGPP response, and implying that the SSD is not a binding site for GGPP. Non-functional SSD mutants allowed us to test the importance of Hmg2 quaternary structure in mallostery:  a non-responsive Hmg2 SSD mutant strongly suppressed regulation of a co-expressed, normal Hmg2. Finally, we have found that GGPP-regulated misfolding occurred in detergent-solubilized Hmg2, a feature that will allow next-level analysis of the mechanism of this novel tactic of ligand-regulated misfolding.

New Venture Growth: Role of Ecosystem Elements and Prior Experience

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Sumita Sarma ◽  
Jacob M. Marszalek
Keyword(s):  
Firm Growth ◽  
New Venture ◽  
Moderating Effects ◽  
Entrepreneurial Ecosystem ◽  
New Firm ◽  
Micro Level ◽  
New Venture Growth ◽  
Prior Experiences ◽  
Level Analysis

AbstractEntrepreneurial ecosystems provide a rich context for analyzing entrepreneurial outcomes such as new venture growth. In most entrepreneurship research, influence of context or environment is undermined or controlled. Also, most studies consider either macro- or micro-level factors using single-level analysis, which mute the higher-level influences on new firm growth. To overcome these gaps, we empirically consider macro- and micro-level factors together, and their cross-level interactions to portray the nexus of entrepreneurs and entrepreneurial ecosystem in growth of new independent ventures in the various US metros. Our findings provide interesting insights on the moderating effects of prior experiences of founders on ecosystem attributes and firm growth.

‘Street-level justifications’: Service providers mediating refugee reception in the urban context of Istanbul

2020 ◽  
Author(s):  
AyŞen Üstübici
Keyword(s):  
Service Providers ◽  
Urban Context ◽  
Government Officials ◽  
Migrant Populations ◽  
Mediating Role ◽  
Displaced Populations ◽  
Street Level ◽  
Cultural Similarity ◽  
Level Analysis

Abstract This article discusses the mediating role of service providers between citizens and refugee reception policies. Based on an analysis of interviews with local government officials and NGO workers and observations in two districts of Istanbul, I examine the ‘street-level justifications’ that service providers use to counter anti-refugee resentments expressed by the citizens. The article suggests that as street-level bureaucrats endeavour to justify their work with refugees through three types discursive strategies; cultural similarity, call for empathy, and pragmatic explanations. Such strategies by constantly re-defining us and them, bear implications for social cohesion. The article offers a meso-level analysis of refugee reception policies in the Turkish context and highlights the limits of initial hospitality. The findings have wider implications for other contexts where the settlement of displaced or migrant populations is rather nascent, policies are top-down and where bureaucratic structures mediate among displaced populations, citizens, and the resources available to them.

The role of personality, culture, and economy in unintentional fatalities: An aggregated level analysis

2007 ◽  
Vol 43 (3) ◽  
pp. 519-530 ◽  
Author(s):  
Türker Özkan ◽  
Timo Lajunen
Keyword(s):  
Level Analysis

scholarly journals Alcohol Availability and Violence among Inner-City Adolescents: A Multi-Level Analysis of the Role of Alcohol Outlet Density

2010 ◽  
Vol 46 (3-4) ◽  
pp. 253-262 ◽  
Author(s):  
Stella M. Resko ◽  
Maureen A. Walton ◽  
C. Raymond Bingham ◽  
Jean T. Shope ◽  
Marc Zimmerman ◽  
...  
Keyword(s):  
Inner City ◽  
Alcohol Outlet ◽  
Alcohol Availability ◽  
Alcohol Outlet Density ◽  
Outlet Density ◽  
Multi Level ◽  
Level Analysis

scholarly journals Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions

2021 ◽  
Author(s):  
Eden Yifrach ◽  
Duncan Holbrook-Smith ◽  
Jérôme Bürgi ◽  
Alaa Othman ◽  
Miriam Eisenstein ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Protein Targeting ◽  
Cellular Metabolism ◽  
Metabolomic Analysis ◽  
Health And Disease ◽  
Multi Level ◽  
Crucial Part ◽  
Level Analysis

AbstractSeventy years following the discovery of peroxisomes, their proteome remains undefined. Uncovering the complete peroxisomal proteome, the peroxi-ome, is crucial for understanding peroxisomal activities and cellular metabolism. We used high- content microscopy to uncover the peroxi-ome of the model eukaryote – Saccharomyces cerevisiae. This strategy enabled us to expand the known organellar proteome by ∼40% and paved the way for performing systematic, whole-organellar proteome assays. Coupled with targeted experiments this allowed us to discover new peroxisomal functions. By characterizing the sub-organellar localization and protein targeting dependencies into the organelle, we unveiled non-canonical targeting routes. Metabolomic analysis of the peroxi-ome revealed the role of several newly-identified resident enzymes. Importantly, we found a regulatory role of peroxisomes during gluconeogenesis, which is fundamental for understanding cellular metabolism. With the current recognition that peroxisomes play a crucial part in organismal physiology, our approach lays the foundation for deep characterization of peroxisome function in health and disease.

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