Yarn-dyed textiles complement digital printing textiles, which hold promise for high production and environmentally friendly energy efficiencies. However, the complicated structures of color-blended yarns lead to unpredictable colors in textile products and become a roadblock to developing nonpollution textile products. In the present work, we propose a framework of intelligent manufacturing of color blended yarn by combining the color prediction algorithm with a self-developed computer numerically controlled (CNC) ring spinning system. The S-N model is used for the prediction of the color blending effect of the ring-spun yarn. The optimized blending ratios of ring-spun yarn are obtained based on the proposed linear model of parameter W. Subsequently, the CNC ring-spinning frame is used to manufacture color-blended yarns, which can configure the constituent fibers in such a way that different sections of yarn exhibit different colors.