P.001 Long-term consequences of alcohol consumption: sex-dependent endogenous opioid system genes regulation

The development of alcohol dependence and depression is determined by various genetic and environmental factors. In the presented study, we used high analgesia (HA) and low analgesia (LA) mouse lines, characterized by different endogenous opioid system activity and divergent blood–brain barrier permeability, to determine the influence of cross-fostering of these lines raised by surrogate mothers on ethanol consumption and development of depressive-like behaviors. We also investigated ethanol drinking by biological parents or surrogate mothers. Furthermore, we investigated whether these parental changes would alter the effect of naloxone on ethanol intake and depressive-like behaviors in offspring. Our results reveal that cross-fostering of HA and LA raised by surrogate mothers has a greater impact on depressive-like behaviors than ethanol consumption. Ethanol intake by biological parents substantially affected depressive-like behaviors and ethanol consumption in offspring. Moreover, ethanol intake by biological parents or an adoptive mother modified the effect of naloxone on ethanol consumption and preference and depressive-like behaviors in the HA offspring only. Together, these results indicate that cross-fostering differentially affects the effect of naloxone on alcohol consumption and the development of depression.

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MODULATION BY CCK-B RECEPTORS OF THE ANTINOCICEPTIVE AND REWARDING PROPERTIES INDUCED BY THE ENDOGENOUS OPIOID SYSTEM

Analgesia ◽

10.3727/107156995819562835 ◽

1995 ◽

Vol 1 (4) ◽

pp. 809-812

Author(s):

O. Valverde ◽

M.-C. Fournié-Zaluski ◽

B. P. Roques ◽

R. Maldonado

Keyword(s):

Opioid System ◽

Endogenous Opioid System ◽

Endogenous Opioid

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Nicotine Effects and the Endogenous Opioid System

Journal of Pharmacological Sciences ◽

10.1254/jphs.14r03cp ◽

2014 ◽

Vol 125 (2) ◽

pp. 117-124 ◽

Cited By ~ 28

Author(s):

Shiroh Kishioka ◽

Norikazu Kiguchi ◽

Yuka Kobayashi ◽

Fumihiro Saika

Keyword(s):

Opioid System ◽

Endogenous Opioid System ◽

Endogenous Opioid

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The Roles of Endogenous Opioid System in the Antidepressant Actions of Ketamine

Biological Psychiatry ◽

10.1016/j.biopsych.2021.02.956 ◽

2021 ◽

Vol 89 (9) ◽

pp. S385

Author(s):

Cheng Jiang ◽

Ralph DiLeone ◽

Christopher Pittenger ◽

Ronald Duman

Keyword(s):

Opioid System ◽

Endogenous Opioid System ◽

Endogenous Opioid

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Role of the endogenous opioid system in the analgesic effect of ?-tocopherol in dysmenorrhea

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00835681 ◽

1988 ◽

Vol 105 (2) ◽

pp. 162-164 ◽

Cited By ~ 2

Author(s):

G. N. Kryzhanovskii ◽

L. P. Bakuleva ◽

N. L. Luzina ◽

V. A. Vinogradov ◽

K. N. Yarygin ◽

...

Keyword(s):

Analgesic Effect ◽

Opioid System ◽

Endogenous Opioid System ◽

Endogenous Opioid

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Modulation of the endogenous opioid system after morphine self-administration and during its extinction: A study in Lewis and Fischer 344 rats

Neuropharmacology ◽

10.1016/j.neuropharm.2006.10.011 ◽

2007 ◽

Vol 52 (3) ◽

pp. 931-948 ◽

Cited By ~ 36

Author(s):

Pilar Sánchez-Cardoso ◽

Alejandro Higuera-Matas ◽

Sonsoles Martín ◽

Nuria del Olmo ◽

Miguel Miguéns ◽

...

Keyword(s):

Opioid System ◽

Fischer 344 Rats ◽

Endogenous Opioid System ◽

Self Administration ◽

Endogenous Opioid ◽

Fischer 344

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Endogenous opioid system in developing normal and jimpy oligodendrocytes: ? and ? opioid receptors mediate differential mitogenic and growth responses

Glia ◽

10.1002/(sici)1098-1136(199802)22:2<189::aid-glia10>3.0.co;2-u ◽

1998 ◽

Vol 22 (2) ◽

pp. 189-201 ◽

Cited By ~ 58

Author(s):

Pamela E. Knapp ◽

Katalin Maderspach ◽

Kurt F. Hauser

Keyword(s):

Opioid Receptors ◽

Opioid System ◽

Growth Responses ◽

Endogenous Opioid System ◽

Endogenous Opioid

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Interleukin-6 is differently modulated by central opioid receptor subtypes

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1997.273.3.r956 ◽

1997 ◽

Vol 273 (3) ◽

pp. R956-R959 ◽

Cited By ~ 1

Author(s):

M. Bertolucci ◽

C. Perego ◽

M. G. De Simoni

Keyword(s):

Opioid Receptor ◽

Fine Tuning ◽

Opioid System ◽

Receptor Subtypes ◽

Receptor Blockade ◽

Endogenous Opioid System ◽

Endogenous Opioid ◽

General Role ◽

Opioid Receptor Subtypes ◽

Mu Antagonist

The central endogenous opioid system is involved in the modulation of interleukin (IL)-6, an inflammatory cytokine that plays a major role in the acute phase response. The present study evaluates whether specific opioid receptor subtypes are selectively involved in this immunomodulatory action. IL-1 beta was administered either intracerebroventricularly or intraperitoneally at the dose of 400 ng to rats pretreated with the mu-antagonist beta-funaltrexamine, the delta-antagonist naltrindole, or the kappa-antagonist nor-binaltorphimine, each at the doses of 1, 10, and 100 micrograms/rat intracerebroventricularly. Serum IL-6 levels were measured 2 h later. The results show that mu-receptor blockade increases, whereas delta-receptor blockade decreases IL-6 induction, suggesting that the fine tuning exerted by opioids on the immune system may be achieved through a balance of opposing effects. Moreover the three antagonists affect IL-6 induction by central and peripheral IL-1 beta with a similar pattern, indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine.

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