The role of Fc-receptors in the uptake and transport of therapeutic antibodies in the retinal pigment epithelium

2016 ◽  
Vol 145 ◽  
pp. 187-205 ◽  
Author(s):  
Michaela Dithmer ◽  
Kirsten Hattermann ◽  
Prasti Pomarius ◽  
Shereen Hassan Aboul Naga ◽  
Tim Meyer ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Fc Receptors ◽  
Therapeutic Antibodies ◽  
Uptake And Transport

scholarly journals Expression and Role of VEGF in the Adult Retinal Pigment Epithelium

2011 ◽  
Vol 52 (13) ◽  
pp. 9478 ◽  
Author(s):  
Knatokie M. Ford ◽  
Magali Saint-Geniez ◽  
Tony Walshe ◽  
Alisar Zahr ◽  
Patricia A. D'Amore
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment

scholarly journals Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes

2020 ◽  
Vol 21 (11) ◽  
pp. 3830 ◽  
Author(s):  
Yan Levitsky ◽  
Sandra S. Hammer ◽  
Kiera P. Fisher ◽  
Chao Huang ◽  
Travan L. Gentles ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Mitochondrial Function ◽  
High Glucose ◽  
Citrate Synthase ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Intercellular Adhesion Molecule ◽  
Early Event ◽  
Rpe Cells

Mitochondrial damage in the cells comprising inner (retinal endothelial cells) and outer (retinal pigment epithelium (RPE)) blood–retinal barriers (BRB) is known to precede the initial BRB breakdown and further histopathological abnormalities in diabetic retinopathy (DR). We previously demonstrated that activation of acid sphingomyelinase (ASM) is an important early event in the pathogenesis of DR, and recent studies have demonstrated that there is an intricate connection between ceramide and mitochondrial function. This study aimed to determine the role of ASM-dependent mitochondrial ceramide accumulation in diabetes-induced RPE cell damage. Mitochondria isolated from streptozotocin (STZ)-induced diabetic rat retinas (7 weeks duration) showed a 1.64 ± 0.29-fold increase in the ceramide-to-sphingomyelin ratio compared to controls. Conversely, the ceramide-to-sphingomyelin ratio was decreased in the mitochondria isolated from ASM-knockout mouse retinas compared to wild-type littermates, confirming the role of ASM in mitochondrial ceramide production. Cellular ceramide was elevated 2.67 ± 1.07-fold in RPE cells derived from diabetic donors compared to control donors, and these changes correlated with increased gene expression of IL-1β, IL-6, and ASM. Treatment of RPE cells derived from control donors with high glucose resulted in elevated ASM, vascular endothelial growth factor (VEGF), and intercellular adhesion molecule 1 (ICAM-1) mRNA. RPE from diabetic donors showed fragmented mitochondria and a 2.68 ± 0.66-fold decreased respiratory control ratio (RCR). Treatment of immortalized cell in vision research (ARPE-19) cells with high glucose resulted in a 25% ± 1.6% decrease in citrate synthase activity at 72 h. Inhibition of ASM with desipramine (15 μM, 1 h daily) abolished the decreases in metabolic functional parameters. Our results are consistent with diabetes-induced increase in mitochondrial ceramide through an ASM-dependent pathway leading to impaired mitochondrial function in the RPE cells of the retina.

scholarly journals Epiretinal membrane surgery for combined hamartoma of the retina and retinal pigment epithelium: role of multimodal analysis

2013 ◽  
pp. 179 ◽  
Author(s):  
Claudia Bruè ◽  
Saitta ◽  
Nicolai ◽  
Mariotti ◽  
Giovannini
Keyword(s):  
Retinal Pigment Epithelium ◽  
Epiretinal Membrane ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Multimodal Analysis

scholarly journals Role of retinal pigment epithelium-derived exosomes and autophagy in new blood vessel formation

2018 ◽  
Vol 22 (11) ◽  
pp. 5244-5256 ◽  
Author(s):  
Sandra Atienzar-Aroca ◽  
Gemma Serrano-Heras ◽  
Aida Freire Valls ◽  
Carmen Ruiz de Almodovar ◽  
Maria Muriach ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Blood Vessel ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Blood Vessel Formation ◽  
Vessel Formation

Role of congenital hypertrophy of the retinal pigment epithelium in the predictive diagnosis of familial adenomatous polyposis

1992 ◽  
Vol 79 (7) ◽  
pp. 689-693 ◽  
Author(s):  
D. G. Morton ◽  
J. Gibson ◽  
F. Macdonald ◽  
R. Brown ◽  
J. Haydon ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Familial Adenomatous Polyposis ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Adenomatous Polyposis ◽  
Predictive Diagnosis ◽  
Congenital Hypertrophy
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