Efficacy and safety of intra-arterial steroid infusions in patients with steroid-resistant gastrointestinal acute graft-versus-host disease

2015 ◽  
Vol 43 (12) ◽  
pp. 995-1000 ◽  
Author(s):  
Mitsutaka Nishimoto ◽  
Hideo Koh ◽  
Asao Hirose ◽  
Mika Nakamae ◽  
Takahiko Nakane ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Efficacy And Safety ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

scholarly journals Psoralen and ultraviolet A irradiation (PUVA) as therapy for steroid-resistant cutaneous acute graft-versus-host disease

2002 ◽  
Vol 8 (4) ◽  
pp. 206-212 ◽  
Author(s):  
Terry Furlong ◽  
Wendy Leisenring ◽  
Rainer Storb ◽  
Claudio Anasetti ◽  
Frederick R Appelbaum ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Ultraviolet A ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

scholarly journals Treatment of steroid-resistant acute graft-versus-host disease with anti-thymocyte globulin

2001 ◽  
Vol 27 (10) ◽  
pp. 1059-1064 ◽  
Author(s):  
H Khoury ◽  
A Kashyap ◽  
DR Adkins ◽  
RA Brown ◽  
G Miller ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

A Phase II Study of BTI-322, a Monoclonal Anti-CD2 Antibody, for Treatment of Steroid-Resistant Acute Graft-Versus-Host Disease

Blood ◽  
1998 ◽  
Vol 92 (11) ◽  
pp. 4066-4071 ◽  
Author(s):  
Donna Przepiorka ◽  
Gordon L. Phillips ◽  
Voravit Ratanatharathorn ◽  
Michele Cottler-Fox ◽  
Laurie H. Sehn ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
High Dose ◽  
Transplant Recipients ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Total Response Rate ◽  
End Of Treatment ◽  
Acute Graft

BTI-322, a rat monoclonal IgG2b directed against the CD2 antigen on T cells and natural killer (NK) cells, blocks primary and memory alloantigen proliferative responses in vitro. We have evaluated the pharmacokinetics and safety of BTI-322 during treatment of 20 transplant recipients with steroid-refractory acute graft-versus-host disease (GVHD). Treatment consisted of BTI-322 by intravenous (IV) bolus or 30-minute infusion at approximately 0.1 mg/kg/d for 10 days in addition to continuing high-dose steroids and tacrolimus or cyclosporine. Pharmacokinetic sampling was performed in 10 patients; the t1/2 ± SE was 9.1 ± 1.3 hours, the Cmaxwas 2,549 ± 291 ng/mL, the Vd was 3.97 ± 0.95 L, and the Vd/kg was 0.05 ± 0.01 L/kg. Ten patients experienced transient dyspnea sometimes accompanied by nausea, vomiting, diarrhea, and tachycardia shortly after the initial bolus dose of drug, but serious drug-related adverse events were not seen during the remainder of the infusions. At the end of treatment (day 11), there were six patients with complete responses and five with a reduction in grade of GVHD for a total response rate of 55% (95% confidence interval [CI], 32% to 77%). Antibodies targeting CD2 may be active in the treatment of acute GVHD, and evaluation of a humanized form of BTI-322 is warranted.

scholarly journals Antithymocyte globulin therapy for steroid-resistant acute graft versus host disease

2008 ◽  
Vol 83 (10) ◽  
pp. 824-825 ◽  
Author(s):  
Mónica Ballesteros ◽  
Christelle Ferrá ◽  
David Serrano ◽  
Montserrat Batlle ◽  
Josep María Ribera ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Antithymocyte Globulin ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

Anti-α4β7 integrin monoclonal antibody (vedolizumab) for the treatment of steroid-resistant severe intestinal acute graft-versus-host disease

2018 ◽  
Vol 54 (7) ◽  
pp. 987-993 ◽  
Author(s):  
Ivetta Danylesko ◽  
Adomas Bukauskas ◽  
Martin Paulson ◽  
Valdas Peceliunas ◽  
Tobias Gedde-Dahl d.y ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Graft Versus Host Disease ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

scholarly journals Early antithymocyte globulin therapy improves survival in patients with steroid-resistant acute graft-versus-host disease

2002 ◽  
Vol 8 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Margaret L MacMillan ◽  
Daniel J Weisdorf ◽  
Stella M Davies ◽  
Todd E DeFor ◽  
Linda J Burns ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Antithymocyte Globulin ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft
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