scholarly journals Olfactory ensheathing cells from the nose: Clinical application in human spinal cord injuries

2011 ◽  
Vol 229 (1) ◽  
pp. 174-180 ◽  
Author(s):  
Alan Mackay-Sim ◽  
James A. St John
Keyword(s):  
Spinal Cord ◽  
Clinical Application ◽  
Spinal Cord Injuries ◽  
Olfactory Ensheathing Cells ◽  
Human Spinal Cord ◽  
Ensheathing Cells

scholarly journals Corrigendum to “Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries”

2017 ◽  
Vol 2017 ◽  
pp. 1-1 ◽  
Author(s):  
Anna Zadroga ◽  
Katarzyna Jezierska-Woźniak ◽  
Joanna Czarzasta ◽  
Monika Barczewska ◽  
Joanna Wojtkiewicz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Spinal Cord Injuries ◽  
Therapeutic Potential ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells

Combined transplantation of neural stem cells and olfactory ensheathing cells for the repair of spinal cord injuries

2007 ◽  
Vol 69 (6) ◽  
pp. 1234-1237 ◽  
Author(s):  
Q. Ao ◽  
A.J. Wang ◽  
G.Q. Chen ◽  
S.J. Wang ◽  
H.C. Zuo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Spinal Cord Injuries ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells

Preparation of Human Olfactory Ensheathing Cells for the Therapy of Spinal Cord Injuries

2018 ◽  
Vol 164 (4) ◽  
pp. 523-527 ◽  
Author(s):  
А. D. Voronova ◽  
O. V. Stepanova ◽  
M. P. Valikhov ◽  
A. V. Chadin ◽  
А. S. Dvornikov ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injuries ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells

scholarly journals Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Zadroga Anna ◽  
Jezierska-Woźniak Katarzyna ◽  
Czarzasta Joanna ◽  
Monika Barczewska ◽  
Wojtkiewicz Joanna ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Spinal Cord Injuries ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Olfactory Ensheathing Cells ◽  
Cord Injury ◽  
Ensheathing Cells

Spinal cord injury (SCI) is a devastating neurological condition that affects individuals worldwide, significantly reducing quality of life, for both patients and their families. In recent years there has been a growing interest in cell therapy potential in the context of spinal cord injuries. The present review aims to discuss and compare the restorative approaches based on the current knowledge, available spinal cord restorative cell therapies, and use of selected cell types. However, treatment options for spinal cord injury are limited, but rehabilitation and experimental technologies have been found to help maintain or improve remaining nerve function in some cases. Mesenchymal stem cells as well as olfactory ensheathing cells seem to show therapeutic impact on damaged spinal cord and might be useful in neuroregeneration. Recent research in animal models and first human trials give patients with spinal cord injuries hope for recovery.

Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury

2013 ◽  
Vol 22 (9) ◽  
pp. 1591-1612 ◽  
Author(s):  
Pawel Tabakow ◽  
Wlodzimierz Jarmundowicz ◽  
Bogdan Czapiga ◽  
Wojciech Fortuna ◽  
Ryszard Miedzybrodzki ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Olfactory Ensheathing Cells ◽  
Human Spinal Cord ◽  
Cord Injury ◽  
Ensheathing Cells

scholarly journals Clinical application of olfactory ensheathing cells in the treatment of spinal cord injury

2013 ◽  
Vol 41 (2) ◽  
pp. 473-481 ◽  
Author(s):  
Yaojian Rao ◽  
Wenxiao Zhu ◽  
Huijuan Liu ◽  
Chunxia Jia ◽  
Qingan Zhao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Clinical Application ◽  
Olfactory Ensheathing Cells ◽  
Cord Injury ◽  
Ensheathing Cells

Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury

2013 ◽  
Author(s):  
Pawel Tabakow ◽  
Wlodzimierz Jarmundowicz ◽  
Bogdan Czapiga ◽  
Wojciech Fortuna ◽  
Ryszard Miedzybrodzki ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Olfactory Ensheathing Cells ◽  
Human Spinal Cord ◽  
Cord Injury ◽  
Ensheathing Cells

scholarly journals Reconstruction of the Damaged Dorsal Root Entry Zone by Transplantation of Olfactory Ensheathing Cells

2019 ◽  
Vol 28 (9-10) ◽  
pp. 1212-1219 ◽  
Author(s):  
Andrew Collins ◽  
Ahmed Ibrahim ◽  
Daqing Li ◽  
Modinat Liadi ◽  
Ying Li
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Dorsal Root ◽  
Spinal Cord Injuries ◽  
Dorsal Column ◽  
Olfactory Ensheathing Cells ◽  
Entry Zone ◽  
Dorsal Root Entry Zone ◽  
Root Entry Zone ◽  
Ensheathing Cells

The dorsal root entry zone is often used in research to examine the disconnection between the central and peripheral parts of the nervous system which occurs following injury. Our laboratory and others have used transplantation of olfactory ensheathing cells (OECs) to repair experimental spinal cord injuries. We have previously used a four dorsal root (C6–T1) transection model to show that transplantation of OECs can reinstate rat forelimb proprioception in a climbing task. Until now, however, we have not looked in detail at the anatomical interaction between OECs and the peripheral/central nervous system regions which form the transitional zone. In this study, we compared short- and long-term OEC survival and their interaction with the surrounding dorsal root tissue. We reveal how transplanted OECs orient toward the spinal cord and allow newly formed axons to travel across into the dorsal horn of the spinal cord. Reconstruction of the dorsal root entry zone was supported by OEC ensheathment of axons at the injured site and also at around 3 mm further away at the dorsal root ganglion. Quantitative analysis revealed no observable difference in dorsal column axonal loss between transplanted and control groups of rats.

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