Can statins improve ovarian graft reception?

ABSTRACT Compensatory growth and the compensatory increase of the number of ovulations in the remaining ovary after unilateral ovariectomy were compared in three groups of rats: I. Rats with no ovarian graft. II. Rats with an ovarian autograft in the region of the portal vein. III. Rats with an ovarian autograft in a region draining into the general circulation. Compensatory growth was not inhibited by ovarian grafts placed in the region of the portal vein, whereas this was inhibited with grafts of the same volume but draining into the general circulation. This finding supports the view that compensatory ovarian growth after unilateral ovariectomy is at least partially the result of an increase in the gonadotrophin level in the blood, following the decrease in oestrogen level. In contrast, the total number of ovulations did not differ significantly in the three groups. The number of ovulations in the ovary in situ was in most cases decreased, when ovulations had occurred in the grafts, even in animals with a graft in the region of the portal vein. These findings are discussed.

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Ovarian graft in the uterus

The American Journal of Surgery ◽

10.1016/s0002-9610(30)90983-x ◽

1930 ◽

Vol 10 (2) ◽

pp. 305-307 ◽

Cited By ~ 7

Author(s):

G.S Foster

Keyword(s):

Ovarian Graft

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Ovarian Mucinous Cystadenoma After Ovarian Graft

Obstetrics and Gynecology ◽

10.1097/aog.0000000000001990 ◽

2017 ◽

Vol 129 (6) ◽

pp. 1035-1036 ◽

Cited By ~ 2

Author(s):

Carole Fajau-Prevot ◽

Yann Tanguy Le Gac ◽

Christine Chevreau ◽

Clémentine Cohade ◽

Nicolas Gatimel ◽

...

Keyword(s):

Mucinous Cystadenoma ◽

Ovarian Graft

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XI.—The Effects of Implantation upon Ovarian Grafts in the Male Mouse

Proceedings of the Royal Society of Edinburgh ◽

10.1017/s037016460002575x ◽

1928 ◽

Vol 47 ◽

pp. 148-164

Author(s):

Y. Tamura

Keyword(s):

Male Mouse ◽

Germinal Epithelium ◽

Interstitial Tissue ◽

Corpora Lutea ◽

Male Mice ◽

Follicular Cells ◽

Ovarian Structure ◽

Series Of Experiments ◽

Ovarian Graft ◽

Time Of Operation

SummaryI. A series of experiments is described in which ovaries from litter sisters at the age of from 8 to 20 weeks old were grafted on to the surface of the kidney of male mice.II. The grafts were examined at periods varying from 10 to 35 days after operation. It was found that in the majority of cases the graft had retained the typical ovarian structure; in one case corpora lutea were present (35 days after transplantation).III. It is suggested that the survival of the graft is dependent primarily upon its vascularisation, and secondarily upon the degree of activity of the germinal epithelium.IV. It is assumed that if the germinal epithelium is unimpaired it proliferates; proliferation occurs first sometime before the 10th day, and continues until the graft has attained the stage at which it was at the time of operation.V. The original large follicles begin to degenerate soon after transplantation; the medium-sized and small ones develop for a certain period of time, but afterwards also undergo degeneration.VI. Graafian follicles undergo degeneration at various stages of development.VII. Interstitial tissue appears to be derived from the follicular cells of the atretic, or more probably of the primary and medium-sized anovular follicles.VIII. It is concluded that the presence of the testis does not affect the vitality of the ovarian graft.

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EXPERIMENTS WITH THE LOCAL ACTION OF OESTROGEN ON THE INTRASPLENIC OVARIAN GRAFT

Obstetrical & Gynecological Survey ◽

10.1097/00006254-195106000-00027 ◽

1951 ◽

Vol 6 (3) ◽

pp. 384

Author(s):

R. Iglesias ◽

A. Lipschütz ◽

Guillermo Rojas

Keyword(s):

Local Action ◽

Ovarian Graft

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DIE WIRKUNG VON HYPOPHYSENHORMONEN AUF DAS IN DIE MILZ IMPLANTIERTE OVAR

Acta Endocrinologica ◽

10.1530/acta.0.0480369 ◽

1965 ◽

Vol 48 (3) ◽

pp. 369-374 ◽

Cited By ~ 1

Author(s):

E. Fels ◽

V. G. Foglia ◽

L. M. Rivera Cortés

Keyword(s):

Ovarian Graft ◽

Positive Effect

ABSTRACT The atrophy of the intrasplenic ovarian graft or that of the graft's tumour, produced by the hypophysectomy may be avoided by the application of chorionic and serum gonadotrophins. Also somatotrophin has a positive effect, almost equal to gonadotrophins with regard to the tumour; its action upon the non tumorous graft is much slighter. While combining gonadotrophins with somatotrophin, the percentage of non atrophic grafts increases twice as much in comparison with the sole application of somatotrophin, but remains much inferior to the results obtained by the injection of gonadotrophins only. Prolactin has no effect at all, neither upon the graft nor upon the tumour once developed.

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