A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana

2013 ◽  
Vol 136 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Yu Feng ◽  
Min Li ◽  
Jing Liu ◽  
Teng-Yang Xu ◽  
Ruo-Si Fang ◽  
...  
Keyword(s):  
Betulinic Acid ◽  
Microbial Transformation ◽  
Cunninghamella Blakesleeana ◽  
One Step

Microbial Transformation of Dextromethorphan by Cunninghamella blakesleeana AS 3.153

2007 ◽  
Vol 55 (4) ◽  
pp. 658-661 ◽  
Author(s):  
Lihong Lin ◽  
Haihua Huang ◽  
Peng Zhang ◽  
Xiulan Qi ◽  
Dafang Zhong
Keyword(s):  
Microbial Transformation ◽  
Cunninghamella Blakesleeana

Microbial transformation of ruscogenins by Cunninghamella blakesleeana

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
Ö Özçinar ◽  
Ö Tağ ◽  
B Kivçak ◽  
E Bedir
Keyword(s):  
Microbial Transformation ◽  
Cunninghamella Blakesleeana

Microbial transformation of Astragalus sapogenins using Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552

2015 ◽  
Vol 115 ◽  
pp. 29-34 ◽  
Author(s):  
Erdal Bedir ◽  
Ceyda Kula ◽  
Özlem Öner ◽  
Melis Altaş ◽  
Özgür Tağ ◽  
...  
Keyword(s):  
Microbial Transformation ◽  
Cunninghamella Blakesleeana

Microbial transformation of danazol with Cunninghamella blakesleeana and anti-cancer activity of danazol and its transformed products

Steroids ◽  
2016 ◽  
Vol 105 ◽  
pp. 121-127 ◽  
Author(s):  
Elias Baydoun ◽  
Atia-tul-Wahab ◽  
Hina Mehmood ◽  
Malik Shoaib Ahmad ◽  
Rizwana Malik ◽  
...  
Keyword(s):  
Microbial Transformation ◽  
Cunninghamella Blakesleeana ◽  
Anti Cancer ◽  
Cancer Activity

Microbial transformation of contraceptive drug etonogestrel into new metabolites with Cunninghamella blakesleeana and Cunninghamella echinulata

Steroids ◽  
2016 ◽  
Vol 115 ◽  
pp. 56-61 ◽  
Author(s):  
Elias Baydoun ◽  
Atia-tul Wahab ◽  
Nayab Shoaib ◽  
Malik Shoaib Ahmad ◽  
Roula Abdel-Massih ◽  
...  
Keyword(s):  
Microbial Transformation ◽  
Cunninghamella Echinulata ◽  
Cunninghamella Blakesleeana ◽  
New Metabolites

scholarly journals Biotransformation of the Antimelanoma Agent Betulinic Acid by Bacillus megaterium ATCC 13368

2000 ◽  
Vol 66 (9) ◽  
pp. 3850-3855 ◽  
Author(s):  
Parnali Chatterjee ◽  
Samir A. Kouzi ◽  
John M. Pezzuto ◽  
Mark T. Hamann
Keyword(s):  
Bacillus Megaterium ◽  
Betulinic Acid ◽  
Microbial Transformation ◽  
In Vitro Models ◽  
Human Melanoma ◽  
Preparative Scale ◽  
Mass Spectral ◽  
Resting Cell ◽  
Melanoma Cell Lines

ABSTRACT Microbial transformation of the antimelanoma agent betulinic acid was studied. The main objective of this study was to utilize microorganisms as in vitro models to predict and prepare potential mammalian metabolites of this compound. Preparative-scale biotransformation with resting-cell suspensions of Bacillus megaterium ATCC 13368 resulted in the production of four metabolites, which were identified as 3-oxo-lup-20(29)-en-28-oic acid, 3-oxo-11α-hydroxy-lup-20(29)-en-28-oic acid, 1β-hydroxy-3-oxo-lup-20(29)-en-28-oic acid, and 3β,7β,15α-trihydroxy-lup-20(29)-en-28-oic acid based on nuclear magnetic resonance and high-resolution mass spectral analyses. In addition, the antimelanoma activities of these metabolites were evaluated with two human melanoma cell lines, Mel-1 (lymph node) and Mel-2 (pleural fluid).

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