The outer membrane proteins of Stenotrophomonas maltophilia are potential vaccine candidates for channel catfish ( Ictalurus punctatus )

2016 ◽  
Vol 57 ◽  
pp. 318-324 ◽  
Author(s):  
Xingli Wang ◽  
Lang Peng ◽  
Kaiyu Wang ◽  
Jun Wang ◽  
Yang He ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Outer Membrane ◽  
Ictalurus Punctatus ◽  
Channel Catfish ◽  
Stenotrophomonas Maltophilia ◽  
Outer Membrane Proteins ◽  
Vaccine Candidates ◽  
Potential Vaccine

scholarly journals Outer Membrane Proteins as a Carrier for Detoxified Lipooligosaccharide Conjugate Vaccines for NontypeableHaemophilus influenzae

1999 ◽  
Vol 67 (10) ◽  
pp. 5508-5513 ◽  
Author(s):  
Ting-Huai Wu ◽  
Xin-Xing Gu
Keyword(s):  
Membrane Proteins ◽  
Outer Membrane ◽  
Respiratory Tract Infections ◽  
Outer Membrane Proteins ◽  
Surface Antigens ◽  
Conjugate Vaccines ◽  
Vaccine Candidates ◽  
Potential Vaccine ◽  
Major Surface ◽  
Tract Infections

ABSTRACT Nontypeable Haemophilus influenzae (NTHi) is a common cause of otitis media and respiratory tract infections. Outer membrane proteins (OMP) and lipooligosaccharide (LOS) are major surface antigens of NTHi and potential vaccine candidates. De-O-acylated LOS (dLOS) or oligosaccharide (OS) was coupled to total OMP to form dLOS-OMP and OS-OMP conjugates, while a dLOS-tetanus toxoid (TT) was synthesized for comparison. These conjugates were evaluated in mice and rabbits for immunogenicity. dLOS-OMP elicited a better boostable antibody response against LOS than did dLOS-TT, while OS-OMP was not immunogenic. Formulation of the conjugates with Ribi adjuvant significantly enhanced the immunogenicity of dLOS-OMP and dLOS-TT but not that of OS-OMP. In addition, rabbit antisera elicited by dLOS-OMP but not dLOS-TT (or OMP alone) demonstrated bactericidal activity against 40% of the NTHi strains tested. These results indicate that dLOS is a better derivative of LOS than OS and that OMP is a good carrier for NTHi LOS-based conjugate vaccines.

Immunogenicity of the recombinant leptospiral putative outer membrane proteins as vaccine candidates

Vaccine ◽  
2007 ◽  
Vol 25 (48) ◽  
pp. 8190-8197 ◽  
Author(s):  
Yung-Fu Chang ◽  
Chia-Sui Chen ◽  
Raghavan U.M. Palaniappan ◽  
Hongxuan He ◽  
Sean P. McDonough ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Outer Membrane ◽  
Outer Membrane Proteins ◽  
Vaccine Candidates

Immunoproteomic Identification of Polyvalent Vaccine Candidates from Vibrio parahaemolyticus Outer Membrane Proteins

2010 ◽  
Vol 9 (5) ◽  
pp. 2573-2583 ◽  
Author(s):  
Hui Li ◽  
Ming-Zhi Ye ◽  
Bo Peng ◽  
Hong-Kai Wu ◽  
Chang-Xin Xu ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Outer Membrane ◽  
Vibrio Parahaemolyticus ◽  
Outer Membrane Proteins ◽  
Vaccine Candidates ◽  
Polyvalent Vaccine
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