Tau and amyloid beta differentially affect the innate immune genes expression in Drosophila models of Alzheimer’s disease and β- D Mannuronic acid (M2000) modulates the dysregulation

Gene ◽  
2021 ◽  
pp. 145972
Author(s):  
Anis Barati ◽  
Raheleh Masoudi ◽  
Reza Yousefi ◽  
Malihezaman Monsefi ◽  
Abbas Mirshafiey
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Innate Immune ◽  
Immune Genes ◽  
Mannuronic Acid ◽  
Genes Expression ◽  
Innate Immune Genes ◽  
Drosophila Models

scholarly journals Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on alzheimer’s disease risk in humans

2020 ◽  
Author(s):  
Yiyi Ma ◽  
Lei Yu ◽  
Marta Olah ◽  
Rebecca Smith ◽  
Stephanie R. Oatman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Risk ◽  
Meta Analysis ◽  
Association Analyses ◽  
Cpg Dinucleotides ◽  
Immune Genes ◽  
Activated Microglia ◽  
Innate Immune Genes ◽  
Functional Analyses

AbstractINTRODUCTIONNot all APOE ε4 carriers who survive to advanced age develop Alzheimer’s disease (AD); factors attenuating the risk of ε4 on AD may exist.METHODSGuided by the top ε4-attenuating signals from methylome-wide association analyses (N=572, ε4+ and ε4-) of neurofibrillary tangles and neuritic plaques, we conducted a meta-analysis for pathological AD within the ε4+ subgroups (N=235) across four independent collections of brains. Cortical RNA-seq and microglial morphology measurements were used in functional analyses.RESULTSThree out of the four significant CpG dinucleotides were captured by one principle component (PC1), which interacts with ε4 on AD, and is associated with expression of innate immune genes and activated microglia. In ε4 carriers, reduction in each unit of PC1 attenuated the odds of AD by 58% (OR=2.39, 95%CI=[1.64,3.46], P=7.08×10−6).DISCUSSIONAn epigenomic factor associated with a reduced proportion of activated microglia appears to attenuate the risk of ε4 on AD.

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

1080 Milk yield genotype impacts expression of hepatic innate immune genes during the transition period in Holsteins

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 518-518
Author(s):  
G. T. Cousillas ◽  
W. J. Weber ◽  
B. Walcheck ◽  
D. E. Kerr ◽  
T. H. Elsasser ◽  
...  
Keyword(s):  
Milk Yield ◽  
Transition Period ◽  
Innate Immune ◽  
Immune Genes ◽  
Innate Immune Genes
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