The assessment of the T102C polymorphism of the 5HT2a receptor gene, 3723G/A polymorphism of the NMDA receptor 3A subunit gene (GRIN3A) and 421C/A polymorphism of the NMDA receptor 2B subunit gene (GRIN2B) among cardiac surgery patients with and without delirium

2014 ◽  
Vol 36 (6) ◽  
pp. 753-756 ◽  
Author(s):  
Jakub Kazmierski ◽  
Monika Sieruta ◽  
Andrzej Banys ◽  
Ryszard Jaszewski ◽  
Tomasz Sobow ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Nmda Receptor ◽  
Receptor Gene ◽  
Subunit Gene ◽  
5Ht2a Receptor ◽  
T102c Polymorphism

scholarly journals Glix 13, a New Drug Acting on Glutamatergic Pathways in Children and Animal Models of Autism Spectrum Disorders

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Annamaria Chiara Santini ◽  
Giovanna Maria Pierantoni ◽  
Raffaele Gerlini ◽  
Rosamaria Iorio ◽  
Yinka Olabinjo ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Partial Agonist ◽  
Receptor Gene ◽  
Expression Patterns ◽  
Bioinformatic Analysis ◽  
Autism Spectrum ◽  
Receptor Modulator ◽  
Therapeutic Procedures ◽  
Significant Enrichment ◽  
Glutamatergic Pathways

Recently standardized diagnostic instruments have been developed in diagnostic and therapeutic procedures for Autism Spectrumv Disorders (ASD). According to the DSM-5 criteria, individuals with ASD must show symptoms from early childhood. These symptoms are communication deficits and restricted, repetitive patterns of behaviour. It was recently described by Bioinformatic analysis that 99 modified genes were associated with human autism. Gene expression patterns in the low-line animals show significant enrichment in autism-associated genes and the NMDA receptor gene family was identified among these. Using ultrasonic vocalizations, it was demonstrated that genetic variation has a direct impact on the expression of social interactions. It has been proposed that specific alleles interact with a social reward process in the adolescent mouse modifying their social interaction and their approach toward each other. In this review we report that the monoclonal antibody-derived tetrapeptide GLYX-13 was found to act as an N-methyl-D-aspartate receptor modulator and possesses the ability to readily cross the blood brain barrier. Treatment with the NMDAR glycine site partial agonist GLYX-13 rescued the deficit in the animal model. Thus, the NMDA receptor has been shown to play a functional role in autism, and GLYX-13 shows promise for the treatment of autism in autistic children.

Role of 5-HT2A Receptor Gene T102C Polymorphism in Coronary Artery Disease and Serum Lipid Level

2003 ◽  
Vol 33 (4) ◽  
pp. 269
Author(s):  
Jin Ho Choi ◽  
Shu Ying Zhang ◽  
Young Seok Cho ◽  
Kyoung Kook Whang ◽  
Jun Hee Lee ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Lipid ◽  
Lipid Level ◽  
Receptor Gene ◽  
Serum Lipid Level ◽  
T102c Polymorphism ◽  
Artery Disease

T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction

2000 ◽  
Vol 150 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Shinichiro Yamada ◽  
Hozuka Akita ◽  
Kenji Kanazawa ◽  
Tatsuro Ishida ◽  
Ken-ichi Hirata ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Receptor Gene ◽  
T102c Polymorphism

scholarly journals Conserved Higher-Order Chromatin Regulates NMDA Receptor Gene Expression and Cognition

Neuron ◽  
2014 ◽  
Vol 84 (5) ◽  
pp. 997-1008 ◽  
Author(s):  
Rahul Bharadwaj ◽  
Cyril J. Peter ◽  
Yan Jiang ◽  
Panos Roussos ◽  
Annie Vogel-Ciernia ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Receptor Gene ◽  
Higher Order ◽  
Receptor Gene Expression

scholarly journals Sociability development in mice with cell‐specific deletion of the NMDA receptor NR1 subunit gene

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Sarah L. Ferri ◽  
Ashley A. Pallathra ◽  
Hyong Kim ◽  
Holly C. Dow ◽  
Praachi Raje ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Subunit Gene ◽  
Specific Deletion
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