Relationship between growth hormone in vivo bioactivity, the insulin-like growth factor-I system and bone mineral density in young, physically fit men and women

2008 ◽  
Vol 18 (5) ◽  
pp. 439-445 ◽  
Author(s):  
B.C. Nindl ◽  
J.R. Pierce ◽  
M.J. Durkot ◽  
A.P. Tuckow ◽  
M.J. Kennett ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Growth Factor ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Men And Women ◽  
Factor I ◽  
Growth Factor I

Relationship Between Growth Hormone in vivo Bioactivity, the Insulin-Like Growth Factor-I System and Bone Mineral Density in Young, Physically Fit Men and Women

2008 ◽  
Author(s):  
B. C. Nindl ◽  
J. R. Pierce ◽  
M. J. Durkot ◽  
A. P. Tuckow ◽  
M. J. Kennett ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Growth Factor ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Men And Women ◽  
Factor I ◽  
Growth Factor I

scholarly journals Relationship Between Bioassayable Growth Hormone, The Insulin‐Like Growth Factor‐I System and Bone Mineral Density in Men and Women

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Bradley C Nindl ◽  
M J Durkot ◽  
J R Pierce ◽  
A P Tuckow ◽  
M J Kennett ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Growth Factor ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Men And Women ◽  
Factor I ◽  
Growth Factor I

scholarly journals Growth hormone - insulin-like growth factor-I axis and bone mineral density in adults with thalassemia major

2014 ◽  
Vol 18 (1) ◽  
pp. 32 ◽  
Author(s):  
Ashraf Soliman ◽  
Vincenzo De Sanctis ◽  
Mohamed Yassin ◽  
MohamedO Abdelrahman
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Growth Factor ◽  
Bone Mineral ◽  
Thalassemia Major ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Factor I ◽  
Growth Factor I

Insulin-Like Growth Factor I Is a Determinant of Hip Bone Mineral Density in Men Less Than 60 years of Age: MINOS Study

2004 ◽  
Vol 74 (4) ◽  
pp. 322-329 ◽  
Author(s):  
P. Szulc ◽  
M. O. Joly–Pharaboz ◽  
F. Marchand ◽  
P. D. Delmas
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Factor I ◽  
Growth Factor I

Relationships between insulin-like growth factor-I (IGF-I) and OPG, RANKL, bone mineral density in healthy Chinese women

2007 ◽  
Vol 19 (2) ◽  
pp. 221-226 ◽  
Author(s):  
H.-Y. Zhao ◽  
J.-M. Liu ◽  
G. Ning ◽  
Y.-J. Zhao ◽  
Y. Chen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Bone Mineral ◽  
Chinese Women ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Healthy Chinese

Insulin-like Growth Factor-I and Bone Mineral Density

Bone ◽  
1998 ◽  
Vol 23 (1) ◽  
pp. 13-16 ◽  
Author(s):  
D Collins ◽  
A Woods ◽  
R Herd ◽  
G Blake ◽  
I Fogelman ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Factor I ◽  
Growth Factor I

Dissociation of Bone Mineral Density From Age-related Decreases in Insulin-like Growth Factor-I and Its Binding Proteins in the Male Rat

1994 ◽  
Vol 49 (5) ◽  
pp. B224-B230 ◽  
Author(s):  
M. R. Benedict ◽  
S. Adiyaman ◽  
D. C. Ayers ◽  
F. D. Thomas ◽  
J. D. Calore ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Bone Mineral ◽  
Binding Proteins ◽  
Male Rat ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Factor I ◽  
Age Related ◽  
Growth Factor I

scholarly journals Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study1

1998 ◽  
Vol 83 (12) ◽  
pp. 4257-4262 ◽  
Author(s):  
Jean A. Langlois ◽  
Clifford J. Rosen ◽  
Marjolein Visser ◽  
Marian T. Hannan ◽  
Tamara Harris ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Growth Factor ◽  
Older Women ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Few studies of the GH axis and bone have focused specifically on elderly people. The objective of this study was to determine the association between insulin-like growth factor I (IGF-I) and bone mineral density (BMD) in 425 women and 257 men aged 72–94 who participated in the Framingham Osteoporosis Study component of the Framingham Heart Study in 1992–1993. Serum IGF-I level was determined by RIA. BMD at three femoral sites and the lumbar spine was determined by dual x-ray absorptiometry, and at the radius by single-photon absorptiometry. IGF-I level was positively associated with BMD at all five sites (Ward’s area, femoral neck, trochanter, radius, and lumbar spine) in women after adjustment for weight loss and other factors (P ≤ 0.01) and protein intake in a subset of participants (0.006 < P < 0.07). A threshold effect of higher BMD was evident at each of the 3 femoral sites and the spine (P < 0.03) but not at the radius for women in the highest quintile of IGF-I (≥179 g/liter) vs. those in the lowest four quintiles. IGF-I was not significantly associated with BMD in men. These results indicate that higher IGF-I levels are associated with greater BMD in very old women, and suggest that future clinical trials employing GH may have a role in the development of treatments for older women with osteoporosis.

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