Relationship Between Growth Hormone in vivo Bioactivity, the Insulin-Like Growth Factor-I System and Bone Mineral Density in Young, Physically Fit Men and Women

2008 ◽  
Author(s):  
B. C. Nindl ◽  
J. R. Pierce ◽  
M. J. Durkot ◽  
A. P. Tuckow ◽  
M. J. Kennett ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Growth Factor ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Men And Women ◽  
Factor I ◽  
Growth Factor I

Insulin-like Growth Factor-I and Bone Mineral Density

Bone ◽  
1998 ◽  
Vol 23 (1) ◽  
pp. 13-16 ◽  
Author(s):  
D Collins ◽  
A Woods ◽  
R Herd ◽  
G Blake ◽  
I Fogelman ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Factor I ◽  
Growth Factor I

scholarly journals Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study1

1998 ◽  
Vol 83 (12) ◽  
pp. 4257-4262 ◽  
Author(s):  
Jean A. Langlois ◽  
Clifford J. Rosen ◽  
Marjolein Visser ◽  
Marian T. Hannan ◽  
Tamara Harris ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Growth Factor ◽  
Older Women ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Few studies of the GH axis and bone have focused specifically on elderly people. The objective of this study was to determine the association between insulin-like growth factor I (IGF-I) and bone mineral density (BMD) in 425 women and 257 men aged 72–94 who participated in the Framingham Osteoporosis Study component of the Framingham Heart Study in 1992–1993. Serum IGF-I level was determined by RIA. BMD at three femoral sites and the lumbar spine was determined by dual x-ray absorptiometry, and at the radius by single-photon absorptiometry. IGF-I level was positively associated with BMD at all five sites (Ward’s area, femoral neck, trochanter, radius, and lumbar spine) in women after adjustment for weight loss and other factors (P ≤ 0.01) and protein intake in a subset of participants (0.006 < P < 0.07). A threshold effect of higher BMD was evident at each of the 3 femoral sites and the spine (P < 0.03) but not at the radius for women in the highest quintile of IGF-I (≥179 g/liter) vs. those in the lowest four quintiles. IGF-I was not significantly associated with BMD in men. These results indicate that higher IGF-I levels are associated with greater BMD in very old women, and suggest that future clinical trials employing GH may have a role in the development of treatments for older women with osteoporosis.

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