ID: 3523058 THE ADDITION OF WIDE-AREA TRANSEPITHELIAL SAMPLING WITH THREE-DIMENSIONAL COMPUTER-ASSISTED ANALYSIS (WATS3D) TO FORCEPS BIOPSY IN SCREENING EXAMS OF GERD PATIENTS WITH COLUMNAR EPITHELIUM INCREASES DETECTION OF INTESTINAL METAPLASIA

2021 ◽  
Vol 93 (6) ◽  
pp. AB286-AB287
Author(s):  
Ariel E. Watts ◽  
Swathi Eluri ◽  
Cary C. Cotton ◽  
David M. Chaletsky ◽  
Brian Moloney ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Three Dimensional ◽  
Wide Area ◽  
Columnar Epithelium ◽  
Computer Assisted ◽  
Forceps Biopsy ◽  
Assisted Analysis

Clinical utility of wide-area transepithelial sampling with three-dimensional computer-assisted analysis (WATS3D) in identifying Barrett’s esophagus and associated neoplasia

2020 ◽  
Vol 33 (12) ◽  
Author(s):  
Vivek Kaul ◽  
Seth Gross ◽  
F Scott Corbett ◽  
Zubair Malik ◽  
Michael S Smith ◽  
...  
Keyword(s):  
Barrett's Esophagus ◽  
Clinical Utility ◽  
Three Dimensional ◽  
High Grade Dysplasia ◽  
Wide Area ◽  
Computer Assisted ◽  
Low Grade ◽  
High Grade ◽  
Low Grade Dysplasia ◽  
Assisted Analysis

Summary Sampling error during screening and surveillance endoscopy is a well-recognized problem. Wide-area transepithelial sampling with three-dimensional computer-assisted analysis (WATS3D), used adjunctively to forceps biopsy (FB), has been shown to increase the detection of Barrett’s esophagus (BE) and BE-associated neoplasia. We evaluated the clinical utility of WATS3D and its impact on the management of patients with BE and dysplasia. Between 2013 and 2018, 432 consecutive patients who had a WATS3D positive and an accompanying FB negative result were identified. Physicians were contacted to determine if the WATS3D result impacted their decision to enroll patients in surveillance or increase the frequency of surveillance, recommend ablation, and/or initiate or increase the dose of proton pump inhibitors (PPIs). WATS3D directly impacted the management of 97.8% of 317 BE patients; 96.2% were enrolled in surveillance and 60.2% were started on PPIs or their dose was increased. WATS3D impacted the management of 94.9% and 94.1% of the 98 low-grade dysplasia and 17 high-grade dysplasia patients, respectively. As a result of WATS3D, 33.7% of low-grade dysplasia and 70.6% of high-grade dysplasia patients underwent endoscopic therapy. More than 37% of all dysplasia patients were enrolled in a surveillance program, and nearly 30% were scheduled to be surveilled more frequently. PPIs were either initiated, or the dose was increased in more than 54% of all dysplasia patients. We demonstrate that WATS3D has high clinical utility. By prompting physicians to change their clinical management in patients with negative FB results, WATS3D, used adjunctively to FB, directly impacts patient management, and improves patient outcomes.

Inter-Observer Agreement among Pathologists Using Wide-Area Transepithelial Sampling With Computer-Assisted Analysis in Patients With Barrett’s Esophagus

2015 ◽  
Vol 110 (9) ◽  
pp. 1257-1260 ◽  
Author(s):  
Prashanth R Vennalaganti ◽  
Vijay Naag Kanakadandi ◽  
Seth A Gross ◽  
Sravanthi Parasa ◽  
Kenneth K Wang ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Observer Agreement ◽  
Wide Area ◽  
Computer Assisted ◽  
Assisted Analysis
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