478: Impact of Panel-Reactive Antibodies on Long-Term Outcome in Pediatric Heart Transplant Patients: An Analysis of the United Network of Organ Sharing Database

2009 ◽  
Vol 28 (2) ◽  
pp. S232 ◽  
Author(s):  
J.W. Rossano ◽  
D.L. Morales ◽  
S.W. Denfield ◽  
F. Zafar ◽  
J.L. Jefferies ◽  
...  
2007 ◽  
Vol 24 (1) ◽  
pp. 77-78 ◽  
Author(s):  
Joseph W. Rossano ◽  
William J. Dreyer ◽  
Jeffrey J. Kim ◽  
Jack F. Price ◽  
Sarah K. Clunie ◽  
...  

2010 ◽  
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C. Fernández-Vivancos ◽  
M.J. Paniagua-Martín ◽  
R. Marzoa-Rivas ◽  
E. Barge-Caballero ◽  
Z. Grile-Cancela ◽  
...  

2005 ◽  
Vol 24 (2) ◽  
pp. S70 ◽  
Author(s):  
H. Laks ◽  
F. Mitropoulos ◽  
J. Odim ◽  
J.K. Patel ◽  
A. Marquez ◽  
...  

2010 ◽  
Vol 29 (2) ◽  
pp. S60
Author(s):  
E. Moreno ◽  
A. Velleca ◽  
C. Burch ◽  
J. Patel ◽  
M. Kittleson ◽  
...  

1998 ◽  
Vol 30 (4) ◽  
pp. 1107-1109 ◽  
Author(s):  
R. Adamson ◽  
E. Obispo ◽  
S. Dychter ◽  
W. Dembitsky ◽  
R. Moreno-Cabral ◽  
...  

2016 ◽  
Vol 25 (3) ◽  
pp. 207-209 ◽  
Author(s):  
Anjith Prakash Rajakumar ◽  
Sheriff Ejaz Ahmed ◽  
Roy Varghese ◽  
Sivakumar Kothandam ◽  
Udaya Charan Murmu ◽  
...  

Surgery for primary cardiac tumors in children includes complete resection, partial resection, and cardiac transplantation. A pediatric heart transplant in this setting is associated with significantly higher mortality and poorer long-term outcome, and it is reserved for unresectable tumors. We recently performed an emergency pediatric heart transplant in a 7-year-old boy with an unresectable cardiac fibroma in the left ventricle.


Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Jon Kobashigawa ◽  
Jignesh Patel ◽  
Matt Kawano ◽  
Grace Wu ◽  
Michelle Kittleson ◽  
...  

Background: Sensitized patients prior to heart transplantation are reportedly at risk for hyperacute rejection and for poor outcome after heart transplantation. It is not known whether reduction of circulating antibodies pre-transplant alters post-transplant outcome. Methods: Between July 1993 and July 2003 we reviewed 523 heart transplant patients of which 95 had pre-transplant PRAs >10%. 21/95 were treated pre-transplant for circulating antibodies. These 21 patients had PRAs greater than 10% (majority 50%–100%) and were treated with combination therapy including plasmapheresis and intravenous gamma globulin to reduce antibody counts. The 74 untreated patients with PRAs >10% (untreated presensitized group) and those patients with PRAs <10% (control group) were used for comparison. Routine post-transplant immunosuppression included triple drug therapy (tacrolimus, mycophenolate, and corticosteroids). Results: Circulating antibody levels pre-transplant decreased from a median of 77.5 to 29.0% (p = 0.017), which allowed a negative prospective donor specific cross match and successful heart transplantation. Compared to the untreated presensitized group, and the control group, the treated sensitized patients had similar five year survival (81.1% vs. 75.7% vs. 71.4%, p=0.523) and freedom from cardiac allograft vasculopathy (74.3% vs. 72.7% vs. 76.2%, p=0.850). Conclusion: Treatment of sensitized patients pre-transplant appears to result in comparable long term outcome after heart transplant.


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