Effect of Time of Intraoperative Circulatory Support on Incidence of High-Grade Primary Graft Dysfunction (PGD): Multicenter Analysis on Use of Extracorporeal Life Support (ECLS) during Lung Transplantation

2020 ◽  
Vol 39 (4) ◽  
pp. S328-S329
Author(s):  
M. Hartwig ◽  
G. Loor ◽  
B. Bottiger ◽  
G. Warnecke ◽  
W. Sommer ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Circulatory Support ◽  
High Grade ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Multicenter Analysis

scholarly journals Multimodal Temporary Mechanically Circulatory Assistance for Primary Graft Dysfunction after Heart Transplantation—A Case Report

2021 ◽  
Author(s):  
Moritz B Immohr ◽  
Artur Lichtenberg ◽  
Payam Akhyari ◽  
Udo Boeken
Keyword(s):  
Heart Transplantation ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Therapeutic Option ◽  
Bleeding Complications ◽  
Circulatory Support ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Biventricular Failure ◽  
Va Ecmo

Abstract Background Primary graft dysfunction (PGD) remains a serious complication after heart transplantation (HTx). Although there is no therapy available, veno-arterial extracorporeal life support (va-ECMO), may be a bailout strategy in selected cases. Especially in patients with severe biventricular failure, chances of survival remain poor. Case Summary Here we report a case of a 56-year old patient suffering from severe PGD after HTx with biventricular failure (ejection fraction < 20%) who was successfully bridged to recovery of the donor graft by temporary multimodal mechanically circulatory assistance by combining both, va-ECMO and a microaxial pump (Impella®, Abiomed, Inc., Danvers, MA, USA), a concept also referred as ECMELLA. During ECMELLA support, the patient experienced multiple severe thoracic bleeding complications with need for four re-thoracotomies and temporary open chest situation. Nevertheless, ventricular function recovered and the patient could be weaned from mechanical circulatory support after twelve days. During follow-up, the patient recovered and was successfully discharged. After the following rehabilitation, the patient now shows no persistent signs of heart failure with normal biventricular function of the cardiac graft. Discussion ECMELLA may offer a therapeutic option for patients with severe PGD after HTx. Special awareness and further studies addressing targeted anticoagulation strategies for patients on dual-mechanical support are needed to diminish the incidence of bleeding complications.

scholarly journals Salvage of severe primary graft dysfunction following heart transplantation using extracorporeal life support

2018 ◽  
Vol 31 (4) ◽  
pp. 482-486
Author(s):  
Katalin Martits-Chalangari ◽  
Omar Hernandez ◽  
Aayla K. Jamil ◽  
Huanying Qin ◽  
Joost Felius ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction

Effect of Cold Ischemic Time on the Incidence of High-Grade Primary Graft Dysfunction (PGD): A Multicenter Analysis

2020 ◽  
Vol 39 (4) ◽  
pp. S329
Author(s):  
M. Villavicencio-Theoduloz ◽  
M.A. Kashem ◽  
M. Hartwig ◽  
G. Loor ◽  
G. Warnecke ◽  
...  
Keyword(s):  
High Grade ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Ischemic Time ◽  
Cold Ischemic Time ◽  
Multicenter Analysis

scholarly journals Extracorporeal life support for primary graft dysfunction after heart transplantation

2018 ◽  
Vol 27 (5) ◽  
pp. 778-784 ◽  
Author(s):  
Matteo Pozzi ◽  
Chiara Bottin ◽  
Xavier Armoiry ◽  
Laurent Sebbag ◽  
Pascale Boissonnat ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction
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