Acute Cellular Rejection in Lung Transplant: Can the Bronchoscopist Assess Transbronchial Biopsy Sample Adequacy?

2021 ◽  
Vol 40 (4) ◽  
pp. S319-S320
Author(s):  
K. Young ◽  
M. Neely ◽  
J.M. Reynolds ◽  
K. Mahmood ◽  
E. Pavlisko ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Transbronchial Biopsy ◽  
Acute Cellular Rejection ◽  
Biopsy Sample ◽  
Cellular Rejection

scholarly journals Diagnosis of Acute Cellular Rejection and Antibody-Mediated Rejection on Lung Transplant Biopsies: A Perspective From Members of the Pulmonary Pathology Society

2016 ◽  
Vol 141 (3) ◽  
pp. 437-444 ◽  
Author(s):  
Anja C. Roden ◽  
Dara L. Aisner ◽  
Timothy Craig Allen ◽  
Marie Christine Aubry ◽  
Roberto J. Barrios ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Transbronchial Biopsy ◽  
Acute Cellular Rejection ◽  
Graft Dysfunction ◽  
Antibody Mediated Rejection ◽  
Triple Test ◽  
Pathologic Findings ◽  
Pulmonary Pathology ◽  
Donor Specific Antibodies ◽  
Cellular Rejection

Context.— The diagnosis and grading of acute cellular and antibody-mediated rejection (AMR) in lung allograft biopsies is important because rejection can lead to acute graft dysfunction and/or failure and may contribute to chronic graft failure. While acute cellular rejection is well defined histologically, no reproducible specific features of AMR are currently identified. Therefore, a combination of clinical features, serology, histopathology, and immunologic findings is suggested for the diagnosis of AMR. Objective.— To describe the perspective of members of the Pulmonary Pathology Society (PPS) on the workup of lung allograft transbronchial biopsy and the diagnosis of acute cellular rejection and AMR in lung transplant. Data Sources.— Reports by the International Society for Heart and Lung Transplantation (ISHLT), experience of members of PPS who routinely review lung allograft biopsies, and search of literature database (PubMed). Conclusions.— Acute cellular rejection should be assessed and graded according to the 2007 working formulation of the ISHLT. As currently no specific features are known for AMR in lung allografts, the triple test (clinical allograft dysfunction, donor-specific antibodies, pathologic findings) should be used for its diagnosis. C4d staining might be performed when morphologic, clinical, and/or serologic features suggestive of AMR are identified.

Simkania negevensisand acute cellular rejection in lung transplant recipients

2015 ◽  
Vol 29 (8) ◽  
pp. 705-711 ◽  
Author(s):  
Alainna J. Jamal ◽  
Mariangela R. Resende ◽  
Taisa Prochnow ◽  
Ian McGilvray ◽  
Joseph M. Pilewski ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Acute Cellular Rejection ◽  
Transplant Recipients ◽  
Lung Transplant Recipients ◽  
Cellular Rejection
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