Migration of neural precursor cells derived from olfactory bulb in cochlear nucleus exposed to an augmented acoustic environment

2007 ◽  
Vol 228 (1-2) ◽  
pp. 3-10 ◽  
Author(s):  
Yang Chen ◽  
Jianhua Qiu ◽  
Fuquan Chen ◽  
Shunli Liu
Keyword(s):  
Olfactory Bulb ◽  
Cochlear Nucleus ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Acoustic Environment ◽  
Augmented Acoustic Environment

scholarly journals Magnetic resonance imaging of odorant activity-dependent migration of neural precursor cells and olfactory bulb growth

NeuroImage ◽  
2017 ◽  
Vol 158 ◽  
pp. 232-241 ◽  
Author(s):  
Nikorn Pothayee ◽  
Diana M. Cummings ◽  
Timothy J. Schoenfeld ◽  
Stephen Dodd ◽  
Heather A. Cameron ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Olfactory Bulb ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Resonance Imaging ◽  
Activity Dependent

Calcium-Permeable AMPA Receptors Mediate Glutamatergic Signaling in Neural Precursor Cells of the Postnatal Olfactory Bulb

2010 ◽  
Vol 103 (3) ◽  
pp. 1431-1437 ◽  
Author(s):  
Daniel P. Darcy ◽  
Jeffry S. Isaacson
Keyword(s):  
Olfactory Bulb ◽  
Ampa Receptors ◽  
Adult Life ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Inhibitory Neurons ◽  
Neural Precursor ◽  
Patch Clamp Recording ◽  
Calcium Dependent ◽  
Glutamatergic Signaling

Neural precursor cells (NPCs) in the mammalian olfactory bulb give rise to local inhibitory neurons that integrate into existing circuitry throughout adult life. However, the functional properties of neurotransmitter receptors expressed by NPCs are not well understood. In this study, we use patch-clamp recording and calcium imaging to explore the properties of glutamate receptors expressed by NPCs in the olfactory bulb subependymal layer. We find that calcium-permeable AMPA receptors (AMPARs) are the major receptor type underlying glutamatergic signaling in olfactory bulb NPCs. We also show that when transmitter uptake is reduced, glutamate spillover from distant nerve terminals in the olfactory bulb can activate nonsynaptic NPC AMPARs and generate increases in intracellular calcium. Together, these results suggest that Ca2+ influx via AMPARs may contribute to calcium-dependent processes that govern NPC differentiation and maturation.

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