scholarly journals Investigation of bacterial biofilm in the human middle ear using optical coherence tomography and acoustic measurements

2013 ◽  
Vol 301 ◽  
pp. 193-200 ◽  
Author(s):  
Cac T. Nguyen ◽  
Sarah R. Robinson ◽  
Woonggyu Jung ◽  
Michael A. Novak ◽  
Stephen A. Boppart ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Middle Ear ◽  
Bacterial Biofilm ◽  
Optical Coherence ◽  
Acoustic Measurements ◽  
Human Middle Ear

scholarly journals Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jungeun Won ◽  
Wenzhou Hong ◽  
Pawjai Khampang ◽  
Darold R. Spillman ◽  
Samuels Marshall ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Antibiotic Treatment ◽  
Middle Ear ◽  
Treatment Strategies ◽  
Bacterial Biofilm ◽  
High Dose ◽  
Optical Coherence ◽  
Office Visits ◽  
The Impact

AbstractStudying the impact of antibiotic treatment on otitis media (OM), the leading cause of primary care office visits during childhood, is critical to develop appropriate treatment strategies. Tracking dynamic middle ear conditions during antibiotic treatment is not readily applicable in patients, due to the limited diagnostic techniques available to detect the smaller amount and variation of middle ear effusion (MEE) and middle ear bacterial biofilm, responsible for chronic and recurrent OM. To overcome these challenges, a handheld optical coherence tomography (OCT) system has been developed to monitor in vivo response of biofilms and MEEs in the OM-induced chinchilla model, the standard model for human OM. As a result, the formation of MEE as well as biofilm adherent to the tympanic membrane (TM) was longitudinally assessed as OM developed. Various types of MEEs and biofilms in the chinchilla model were identified, which showed comparable features as those in humans. Furthermore, the effect of antibiotics on the biofilm as well as the amount and type of MEEs was investigated with low-dose and high-dose treatment (ceftriaxone). The capability of OCT to non-invasively track and examine middle ear conditions is highly beneficial for therapeutic OM studies and will lead to improved management of OM in patients.

scholarly journals In Vivo Functional Imaging of the Human Middle Ear with a Hand-Held Optical Coherence Tomography Device

2021 ◽  
Author(s):  
Christopher Lui ◽  
Wihan Kim ◽  
James Dewey ◽  
Frank MACÍAS-ESCRIVÁ ◽  
Kumara RATNAYAKE ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Functional Imaging ◽  
Middle Ear ◽  
Optical Coherence ◽  
Human Middle Ear ◽  
In Vivo Functional Imaging

scholarly journals Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope

2020 ◽  
Vol 162 (3) ◽  
pp. 367-374 ◽  
Author(s):  
Diego Preciado ◽  
Ryan M. Nolan ◽  
Radhika Joshi ◽  
Gina M. Krakovsky ◽  
Anqi Zhang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Middle Ear ◽  
Tertiary Care ◽  
Image Data ◽  
Tube Placement ◽  
Secondary Outcome ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Interreader Agreement ◽  
Blinded Reader

Objective To determine the feasibility of detecting and differentiating middle ear effusions (MEEs) using an optical coherence tomography (OCT) otoscope. Study Design Cross-sectional study. Setting US tertiary care children’s hospital. Subjects and Methods Seventy pediatric patients undergoing tympanostomy tube placement were preoperatively imaged using an OCT otoscope. A blinded reader quiz was conducted using 24 readers from 4 groups of tiered medical expertise. The primary outcome assessed was reader ability to detect presence/absence of MEE. A secondary outcome assessed was reader ability to differentiate serous vs nonserous MEE. Results OCT image data sets were analyzed from 45 of 70 total subjects. Blinded reader analysis of an OCT data subset for detection of MEE resulted in 90.6% accuracy, 90.9% sensitivity, 90.2% specificity, and intra/interreader agreement of 92.9% and 87.1%, respectively. Differentiating MEE type, reader identification of nonserous MEE had 70.8% accuracy, 53.6% sensitivity, 80.1% specificity, and intra/interreader agreement of 82.9% and 75.1%, respectively. Multivariate analysis revealed that age was the strongest predictor of OCT quality. The mean age of subjects with quality OCT was 5.01 years (n = 45), compared to 2.54 years (n = 25) in the remaining subjects imaged ( P = .0028). The ability to capture quality images improved over time, from 50% to 69.4% over the study period. Conclusion OCT otoscopy shows promise for facilitating accurate MEE detection. The imageability with the prototype device was affected by age, with older children being easier to image, similar to current ear diagnostic technologies.

Functional optical coherence tomography for imaging middle ear dynamics

CLEO: 2013 ◽  
2013 ◽  
Author(s):  
E.W. Chang ◽  
J.T. Cheng ◽  
C. Roosli ◽  
J.J. Rosowski ◽  
S.H. Yun
Keyword(s):  
Optical Coherence Tomography ◽  
Middle Ear ◽  
Optical Coherence

Optical coherence tomography of the oval window niche

2009 ◽  
Vol 123 (6) ◽  
pp. 603-608 ◽  
Author(s):  
T Just ◽  
E Lankenau ◽  
G Hüttmann ◽  
H W Pau
Keyword(s):  
Optical Coherence Tomography ◽  
Middle Ear ◽  
Imaging Modality ◽  
Oval Window ◽  
Annular Ligament ◽  
Middle Ear Surgery ◽  
Optical Coherence ◽  
Ear Surgery ◽  
Temporal Bones

AbstractObjective:Optical coherence tomography was used to study the stapes footplate, both in cadaveric temporal bones and during middle-ear surgery.Materials and methods:Optical coherence tomography was conducted on five temporal bone preparations (from two children and three adults) and in eight patients during middle-ear surgery. A specially equipped operating microscope with integrated spectral domain optical coherence tomography apparatus was used for standard middle-ear surgical procedures.Results:This optical coherence tomography investigation enabled in vivo visualisation and documentation of the annular ligament, the different layers of the footplate and the inner-ear structures, both in non-fixed and fixed stapes footplates. In cases of otosclerosis and tympanosclerosis, an inhomogeneous and irregularly thickened footplate was found, in contrast to the appearance of non-fixed footplates. In both fixed and non-fixed footplates, there was a lack of visualisation of the border between the footplate and the otic capsule.Conclusions:Investigation of the relatively new technology of optical coherence tomography indicated that this imaging modality may assist the ear surgeon to assess the oval window niche intra-operatively.

scholarly journals Clinical Doppler-mode optical coherence tomography of the middle ear

2018 ◽  
Author(s):  
Dan Mac Dougall ◽  
Christine Morrison ◽  
Manohar Bance ◽  
David Morris ◽  
Robert B. A. Adamson
Keyword(s):  
Optical Coherence Tomography ◽  
Middle Ear ◽  
Optical Coherence

scholarly journals Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography

2019 ◽  
Vol 5 (9) ◽  
pp. 74
Author(s):  
Jeon ◽  
Kim ◽  
Jeon ◽  
Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Phase Shift ◽  
Tympanic Membrane ◽  
Middle Ear ◽  
Acoustic Stimulus ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Vibratory Motion ◽  
Doppler Optical Coherence Tomography

Optical coherence tomography (OCT) has a micro-resolution with a penetration depth of about 2 mm and field of view of about 10 mm. This makes OCT well suited for analyzing the anatomical and internal structural assessment of the middle ear. To study the vibratory motion of the tympanic membrane (TM) and its internal structure, we developed a phase-resolved Doppler OCT system using Kasai’s autocorrelation algorithm. Doppler optical coherence tomography is a powerful imaging tool which can offer the micro-vibratory measurement of the tympanic membrane and obtain the micrometer-resolved cross-sectional images of the sample in real-time. To observe the relative vibratory motion of individual sections (malleus, thick regions, and the thin regions of the tympanic membrane) of the tympanic membrane in respect to auditory signals, we designed an experimental study for measuring the difference in Doppler phase shift for frequencies varying from 1 to 8 kHz which were given as external stimuli to the middle ear of a small animal model. Malleus is the very first interconnecting region between the TM and cochlea. In our proposed study, we observed that the maximum change in Doppler phase shift was seen for the 4 kHz acoustic stimulus in the malleus, the thick regions, and in the thin regions of the tympanic membrane. In particular, the vibration signals were higher in the malleus in comparison to the tympanic membrane.

Non-contact optical coherence tomography — an effective method for visualizing the exudate of the middle ear

2020 ◽  
Vol 85 (4) ◽  
pp. 16
Author(s):  
A.A. Novozhilov ◽  
P.A. Shilyagin ◽  
T.E. Abubakirov ◽  
A.L. DilenYan ◽  
M.B. Klimycheva ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Middle Ear ◽  
Optical Coherence
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