scholarly journals Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson's Disease

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S476
Author(s):  
Velmarini Vasquez ◽  
Joy Mitra ◽  
Pavana M. Hegde ◽  
Arvind Pandey ◽  
Shiladitya Sengupta ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
In Vitro Models ◽  
Strand Breaks

scholarly journals Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease

2017 ◽  
Vol 60 (s1) ◽  
pp. S133-S150 ◽  
Author(s):  
Velmarini Vasquez ◽  
Joy Mitra ◽  
Pavana M. Hegde ◽  
Arvind Pandey ◽  
Shiladitya Sengupta ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
In Vitro Models ◽  
Strand Breaks

BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson’s Disease

2014 ◽  
Vol 55 (3) ◽  
pp. 587-595 ◽  
Author(s):  
Pawel Kermer ◽  
Anja Köhn ◽  
Marlena Schnieder ◽  
Paul Lingor ◽  
Mathias Bähr ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
In Vitro Models

Carvacrol Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in In Vivo and In Vitro Models of Parkinson’s Disease

2019 ◽  
Vol 37 (1) ◽  
pp. 156-170 ◽  
Author(s):  
Mahboubeh Manouchehrabadi ◽  
Mona Farhadi ◽  
Zahra Azizi ◽  
Anahita Torkaman-Boutorabi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
In Vitro Models ◽  
6 Hydroxydopamine

Pharmacological inhibition of PARP-1 reduces α-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models

2007 ◽  
Vol 357 (3) ◽  
pp. 596-602 ◽  
Author(s):  
Tiago Fleming Outeiro ◽  
Tom N. Grammatopoulos ◽  
Steven Altmann ◽  
Allison Amore ◽  
David G. Standaert ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
In Vitro Models ◽  
Pharmacological Inhibition ◽  
Parp 1

Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease

2007 ◽  
Vol 50 (3) ◽  
pp. 507-516 ◽  
Author(s):  
Yuan Zhu ◽  
Patrick Hoell ◽  
Barbara Ahlemeyer ◽  
Ulrich Sure ◽  
Helmut Bertalanffy ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuronal Death ◽  
Reactive Oxygen ◽  
In Vitro Models ◽  
Oxygen Species

Mimicking Parkinson’s Disease in a Dish: Merits and Pitfalls of the Most Commonly used Dopaminergic In Vitro Models

2017 ◽  
Vol 19 (2-3) ◽  
pp. 241-255 ◽  
Author(s):  
Fernanda Martins Lopes ◽  
Ivi Juliana Bristot ◽  
Leonardo Lisbôa da Motta ◽  
Richard B. Parsons ◽  
Fabio Klamt
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
In Vitro Models

scholarly journals Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 61 ◽  
Author(s):  
Olga F. Smetanina ◽  
Anton N. Yurchenko ◽  
Elena V. Girich (Ivanets) ◽  
Phan Thi Hoai Trinh ◽  
Alexander S. Antonov ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
In Vitro Models ◽  
Biologically Active ◽  
Neuroprotective Activity ◽  
Chiral Hplc ◽  
Cytoprotective Activity ◽  
First Time

Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson’s disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson’s disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.

scholarly journals Statins reduce neuronal α-synuclein aggregation in in vitro models of Parkinson’s disease

2008 ◽  
Vol 105 (5) ◽  
pp. 1656-1667 ◽  
Author(s):  
Pazit Bar-On ◽  
Leslie Crews ◽  
Andrew O. Koob ◽  
Hideya Mizuno ◽  
Anthony Adame ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
In Vitro Models
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