scholarly journals Age-dependent changes in the medial prefrontal cortex and medial amygdala structure, and elevated plus-maze performance in the healthy male Wistar rats

IBRO Reports ◽  
2020 ◽  
Vol 9 ◽  
pp. 183-194
Author(s):  
N. Sotoudeh ◽  
M.R. Namavar ◽  
A. Zarifkar ◽  
A.R. Heidarzadegan
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Medial Amygdala ◽  
Maze Performance ◽  
Healthy Male ◽  
Plus Maze ◽  
Age Dependent ◽  
Male Wistar Rats

scholarly journals Activation of GABAA receptors in the medial prefrontal cortex produces an anxiolytic-like response

2013 ◽  
Vol 25 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Jalal Solati ◽  
Ramin Hajikhani ◽  
Yulia Golub
Keyword(s):  
Prefrontal Cortex ◽  
Receptor Antagonist ◽  
Medial Prefrontal Cortex ◽  
Gabaa Receptors ◽  
Receptor Agonist ◽  
Elevated Plus Maze ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

ObjectivesThere has been increasing evidence that the γ-aminobutyric acid (GABA)ergic system is involved in the neurobiology of anxiety. The present study aimed to investigate the role of GABAergic systems in the modulation of anxiety in the medial prefrontal cortex (mPFC) of rats using the elevated plus maze test.MethodsRats were anaesthetised with a mixture of ketamine and xylazine, and then special cannulae were inserted stereotaxically into the mPFC. After 5–7 days of recovery, the effects of intra-mPFC administration of GABAergic agents were studied.ResultsBilateral injection of the GABAA receptor agonist muscimol (0.25, 0.5 and 1 μg/rat) produces an anxiolytic-like effect, shown by significant increases in the percentage of open-arm time (%OAT) and percentage of open-arm entries (%OAE). Intra-mPFC administration of the GABAA receptor antagonist bicuculline (0.25, 0.5 and 1 μg/rat) produces significant anxiogenic-like behaviour. However, intra-mPFC injection of the GABAB receptor agonist baclofen (0.05, 0.1 and 0.2 μg/rat) and the GABAB receptor antagonist CGP35348 (5, 10 and 15 μg/rat) did not alter %OAT and %OAE significantly.ConclusionThe results of the present study demonstrate that the GABAergic system of the mPFC modulates anxiety-related behaviours of rats through GABAA receptors.

scholarly journals Fear-Potentiated Behaviour Is Modulated by Central Amygdala Angiotensin IIAT1Receptors Stimulation

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Maria de los Angeles Marinzalda ◽  
Pablo A. Pérez ◽  
Pascual A. Gargiulo ◽  
Brenda S. Casarsa ◽  
Claudia Bregonzio ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Central Nucleus ◽  
Anxiety State ◽  
Ang Ii ◽  
Emotional Processes ◽  
Footshock Stress ◽  
Plus Maze ◽  
Male Wistar Rats ◽  
Grooming Behaviour

Central nucleus of the amygdala (CeA) is one of the most important regulatory centres for the emotional processes. Among the different neurotransmitter systems present in this nucleus, AT1receptors have been also found, but their role in the generation and modulation of emotions is not fully understood. The present work evaluated the effect of intra-amygdalar injection of losartan (AT1receptor antagonist) and angiotensin II (Ang II) in the anxiety state induced by fear-potentiated plus maze in male Wistar rats. Fear in the elevated plus maze can be potentiated by prior inescapable footshock stress. The decrease in the time spent in the open arms induced by the inescapable footshock was totally prevented by losartan (4 pmol) administration in CeA. It was also found that Ang II (48 fmol) administration decreased the time spent in the open arms in animals with or without previous footshock exposure. The locomotor activity and grooming behaviour were also evaluated. The results obtained from the different parameters analyzed allowed us to conclude that the Ang II AT1receptors in CeA are involved in the anxiety state induced by stress in the fear-potentiated plus-maze behaviour.

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