Screen for genes in periaqueductal grey of male Wistar rats related to reduced exploratory activity in the elevated plus-maze

2007 ◽  
Vol 183 (1) ◽  
pp. 8-17 ◽  
Author(s):  
A NELOVKOV ◽  
S SUTT ◽  
S RAUD ◽  
E VASAR ◽  
S KOKS
Keyword(s):  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Exploratory Activity ◽  
Periaqueductal Grey ◽  
Plus Maze ◽  
Male Wistar Rats

scholarly journals Fear-Potentiated Behaviour Is Modulated by Central Amygdala Angiotensin IIAT1Receptors Stimulation

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Maria de los Angeles Marinzalda ◽  
Pablo A. Pérez ◽  
Pascual A. Gargiulo ◽  
Brenda S. Casarsa ◽  
Claudia Bregonzio ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Central Nucleus ◽  
Anxiety State ◽  
Ang Ii ◽  
Emotional Processes ◽  
Footshock Stress ◽  
Plus Maze ◽  
Male Wistar Rats ◽  
Grooming Behaviour

Central nucleus of the amygdala (CeA) is one of the most important regulatory centres for the emotional processes. Among the different neurotransmitter systems present in this nucleus, AT1receptors have been also found, but their role in the generation and modulation of emotions is not fully understood. The present work evaluated the effect of intra-amygdalar injection of losartan (AT1receptor antagonist) and angiotensin II (Ang II) in the anxiety state induced by fear-potentiated plus maze in male Wistar rats. Fear in the elevated plus maze can be potentiated by prior inescapable footshock stress. The decrease in the time spent in the open arms induced by the inescapable footshock was totally prevented by losartan (4 pmol) administration in CeA. It was also found that Ang II (48 fmol) administration decreased the time spent in the open arms in animals with or without previous footshock exposure. The locomotor activity and grooming behaviour were also evaluated. The results obtained from the different parameters analyzed allowed us to conclude that the Ang II AT1receptors in CeA are involved in the anxiety state induced by stress in the fear-potentiated plus-maze behaviour.

Augmented voluntary consumption of ethanol induced by reward downshift increases locomotor activity of male Wistar rats in the elevated plus maze

2018 ◽  
Vol 150 ◽  
pp. 59-65 ◽  
Author(s):  
Rocio Donaire ◽  
Shannon E. Conrad ◽  
Joanna B. Thompson ◽  
Mauricio R. Papini ◽  
Carmen Torres
Keyword(s):  
Locomotor Activity ◽  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Plus Maze ◽  
Male Wistar Rats

scholarly journals Ethanol during adolescence decreased the BDNF levels in the hippocampus in adult male Wistar rats, but did not alter aggressive and anxiety-like behaviors

2015 ◽  
Vol 37 (3) ◽  
pp. 143-151 ◽  
Author(s):  
Letícia Scheidt ◽  
Gabriel Rodrigo Fries ◽  
Laura Stertz ◽  
João Carlos Centurion Cabral ◽  
Flávio Kapczinski ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Ethanol Exposure ◽  
Control Group ◽  
Male Intruder ◽  
Plus Maze ◽  
Significant Difference ◽  
Adult Phase ◽  
Male Wistar Rats ◽  
Adolescent Rats

Objective:To investigate the effects of ethanol exposure in adolescent rats during adulthood by assesssing aggression and anxiety-like behaviors and measuring the levels of inflammatory markers.Methods:Groups of male Wistar rats (mean weight 81.4 g, n = 36) were housed in groups of four until postnatal day (PND) 60. From PNDs 30 to 46, rats received one of three treatments: 3 g/kg of ethanol (15% w/v, orally, n = 16), 1.5 g/kg of ethanol (12.5% w/v, PO, n = 12), or water (n = 12) every 48 hours. Animals were assessed for aggressive behavior (resident x intruder test) and anxiety-like behaviors (elevated plus maze) during adulthood.Results:Animals that received low doses of alcohol showed reduced levels of brain-derived neurotrophic factor (BDNF) in the hippocampus as compared to the control group. No significant difference was found in prefrontal cortex.Conclusions:Intermittent exposure to alcohol during adolescence is associated with lower levels of BDNF in the hippocampus, probably due the episodic administration of alcohol, but alcohol use did not alter the level agression toward a male intruder or anxiety-like behaviors during the adult phase.

scholarly journals Participation ofGABAAChloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Juan Francisco Rodríguez-Landa ◽  
Rosa Isela García-Ríos ◽  
Jonathan Cueto-Escobedo ◽  
Blandina Bernal-Morales ◽  
Carlos M. Contreras
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chloride Channels ◽  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Acid Mixture ◽  
Plus Maze ◽  
Gaba Binding ◽  
Defensive Burying

Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μg%; C14:0, myristic acid, 6.9 μg%; C16:0, palmitic acid, 35.3 μg%; C16:1, palmitoleic acid, 16.4 μg%; C18:0, stearic acid, 8.5 μg%; C18:1cis, oleic acid, 18.4 μg%; C18:1trans, elaidic acid, 3.5 μg%; C18:2, linoleic acid, 10.1 μg%) produce anxiolytic-like effects that are comparable to diazepam in Wistar rats, suggesting the involvement ofγ-aminobutyric acid-A (GABAA) receptors, a possibility not yet explored. Wistar rats were subjected to the defensive burying test, elevated plus maze, and open field test. In different groups, threeGABAAreceptor antagonists were administered 30 min before FAT-M administration, including the competitive GABA binding antagonist bicuculline (1 mg/kg),GABAAbenzodiazepine antagonist flumazenil (5 mg/kg), and noncompetitiveGABAAchloride channel antagonist picrotoxin (1 mg/kg). The FAT-M exerted anxiolytic-like effects in the defensive burying test and elevated plus maze, without affecting locomotor activity in the open field test. TheGABAAantagonists alone did not produce significant changes in the behavioral tests. Picrotoxin but not bicuculline or flumazenil blocked the anxiolytic-like effect of the FAT-M. Based on the specific blocking action of picrotoxin on the effects of the FAT-M, we conclude that the FAT-M exerted its anxiolytic-like effects throughGABAAreceptor chloride channels.

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