Activity of the medial prefrontal cortex and amygdala underlies one-trial tolerance of rats in the elevated plus-maze

2008 ◽  
Vol 169 (1) ◽  
pp. 109-118 ◽  
Author(s):  
Lucas Albrechet-Souza ◽  
Karina G. Borelli ◽  
Marcus L. Brandão
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Elevated Plus Maze ◽  
Plus Maze

scholarly journals Activation of GABAA receptors in the medial prefrontal cortex produces an anxiolytic-like response

2013 ◽  
Vol 25 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Jalal Solati ◽  
Ramin Hajikhani ◽  
Yulia Golub
Keyword(s):  
Prefrontal Cortex ◽  
Receptor Antagonist ◽  
Medial Prefrontal Cortex ◽  
Gabaa Receptors ◽  
Receptor Agonist ◽  
Elevated Plus Maze ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

ObjectivesThere has been increasing evidence that the γ-aminobutyric acid (GABA)ergic system is involved in the neurobiology of anxiety. The present study aimed to investigate the role of GABAergic systems in the modulation of anxiety in the medial prefrontal cortex (mPFC) of rats using the elevated plus maze test.MethodsRats were anaesthetised with a mixture of ketamine and xylazine, and then special cannulae were inserted stereotaxically into the mPFC. After 5–7 days of recovery, the effects of intra-mPFC administration of GABAergic agents were studied.ResultsBilateral injection of the GABAA receptor agonist muscimol (0.25, 0.5 and 1 μg/rat) produces an anxiolytic-like effect, shown by significant increases in the percentage of open-arm time (%OAT) and percentage of open-arm entries (%OAE). Intra-mPFC administration of the GABAA receptor antagonist bicuculline (0.25, 0.5 and 1 μg/rat) produces significant anxiogenic-like behaviour. However, intra-mPFC injection of the GABAB receptor agonist baclofen (0.05, 0.1 and 0.2 μg/rat) and the GABAB receptor antagonist CGP35348 (5, 10 and 15 μg/rat) did not alter %OAT and %OAE significantly.ConclusionThe results of the present study demonstrate that the GABAergic system of the mPFC modulates anxiety-related behaviours of rats through GABAA receptors.

Bilateral ischaemic lesions of the medial prefrontal cortex are anxiogenic in the rat

2017 ◽  
Vol 30 (3) ◽  
pp. 181-186 ◽  
Author(s):  
Robert A. Déziel ◽  
R. Andrew Tasker
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Sprague Dawley ◽  
Post Stroke ◽  
Cognition And Emotion ◽  
Post Surgery ◽  
Sprague Dawley Rats ◽  
Plus Maze ◽  
Mood And Cognition ◽  
Reduced Mobility

ObjectiveStroke patients often suffer from delayed disturbances of mood and cognition. In rodents, the prefrontal cortex (PFC) is involved in both higher order cognition and emotion. Our objective was to determine if bilateral focal ischaemic lesions restricted to the medial prefrontal cortex (mPFC) could be used to model post-stroke anxiety and/or cognitive deficits.MethodsGroups of adult male Sprague-Dawley rats (n=9) received bilateral injections of either endothelin-1 (ET-1) (400 pmol) or vehicle (artificial cerebrospinal fluid) into the mPFC and were tested at various times using both a test of temporal order memory and in an elevated plus maze. Lesions were verified histologically.ResultsET-1 lesioned rats had reduced mobility on post-surgery day 8 that had resolved by day 29 at which time they spent significantly more time in the closed arm of the plus mazeConclusionWe conclude that ischaemic lesions localised to the mPFC can be used to model post-stroke anxiety in rats.

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