Endogenous calcium attenuates the immunomodulatory activity of a polysaccharide from Lycium barbarum L. leaves by altering the global molecular conformation

2019 ◽  
Vol 123 ◽  
pp. 182-188 ◽  
Author(s):  
Bo Zhang ◽  
Mengze Wang ◽  
Chu Wang ◽  
Tongtong Yu ◽  
Qiang Wu ◽  
...  
2020 ◽  
Vol 68 (13) ◽  
pp. 4072-4072
Author(s):  
Pei-Feng Zhu ◽  
Yun-Li Zhao ◽  
Zhi Dai ◽  
Xu-Jie Qin ◽  
Hai-Lian Yuan ◽  
...  

2020 ◽  
Vol 68 (10) ◽  
pp. 3079-3087 ◽  
Author(s):  
Pei-Feng Zhu ◽  
Yun-Li Zhao ◽  
Zhi Dai ◽  
Xu-Jie Qin ◽  
Hai-Lian Yuan ◽  
...  

2012 ◽  
Vol 87 (2) ◽  
pp. 1311-1317 ◽  
Author(s):  
Yang Yi ◽  
Ming-Wei Zhang ◽  
Sen-Tai Liao ◽  
Rui-Fen Zhang ◽  
Yuan-Yuan Deng ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Ying Wang ◽  
Mingyi Sun ◽  
Hongyu Jin ◽  
Jianbo Yang ◽  
Shuai Kang ◽  
...  

The mechanism of immunoregulation by Lycium barbarum polysaccharides (LBPs) was assessed by studying the effect of LBP on the immunity and the gut microbiota. LBP isolated and purified in this study was composed of nine monosaccharides, with an Mw 1,207 kDa. LBP showed immunomodulatory activity in cyclophosphamide (Cy)-treated mice by restoring the damaged immune organs and adjusting the T lymphocyte subsets. We also found that LBP increased the diversity of the gut microbiota and the relative abundances of bacteria, such as Rickenellaceae, Prevotellaceae, Bifidobacteriaceae, and so on, which were positively associated with immune traits. In addition, Caco2 cells model was used to explore the intestinal absorption of LBP. Results showed that LBP was hardly absorbed in the intestine, which suggesting that most LBP may interact with gut microbiota. These findings suggest that the immune response induced by LBP is associated with the regulation of the gut microbiota.


Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
A Karioti ◽  
C Bergonzi ◽  
A Bilia

Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
SH Ansari ◽  
V Anjum ◽  
S Ahmad

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